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Y Not Ruskee

Veterinary Report by Embark

embarkvet.com

Test Date: October 24th, 2016

Customer-supplied information

Owner Name: Kerry-Anne Griffin
Dog Name: Y Not Ruskee
Sex: Male (intact)
Date of birth: 01/23/12
Breed type: purebred
Breed: Koolie
Breed registration: German Coolie World Registry
Microchip: n/a

Genetic summary

Genetic breed identification:
Koolie

Breed mix:
Koolie: 100.0%
Predicted adult weight: 60 lbs
Calculated from 17 size genes.

Genetic age: 68 human years
Human equivalent age based on size, date of birth provided, and other factors

Clinical Tools

These clinical genetic tools can inform clinical decisions and diagnoses. These tools do not predict increased risk for disease.

Alanine Aminotransferase Activity (GPT)
Y Not Ruskee's baseline ALT level is Normal
What is Alanine Aminotransferase Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

How vets diagnose this condition

Genetic testing is the only way to provide your veterinarian with this clinical tool.

How this condition is treated

Veterinarians may recommend blood work to establish a baseline ALT value for healthy dogs with one or two copies of this variant.

Health Report

How to interpret Y Not Ruskee’s genetic health results:

If Y Not Ruskee inherited any of the variants that we tested, they will be listed at the top of the Health Report section, along with a description of how to interpret this result. We also include all of the variants that we tested Y Not Ruskee for that we did not detect the risk variant for.

A genetic test is not a diagnosis

This genetic test does not diagnose a disease. Please talk to your vet about your dog’s genetic results, or if you think that your pet may have a health condition or disease.

Good news!

Y Not Ruskee is not at increased risk for the genetic health conditions that Embark tests.
Breed-Relevant Genetic Conditions
8 variants not detected

Additional Genetic Conditions
150 variants not detected

Breed-Relevant Conditions Tested

Y Not Ruskee did not have the variants that we tested for, that are relevant to his breed:

MDR1 Drug Sensitivity (MDR1)
Trapped Neutrophil Syndrome (VPS13B)
Progressive Retinal Atrophy, prcd (PRCD Exon 1)
Collie Eye Anomaly, Choroidal Hypoplasia, CEA (NHEJ1)
Primary Lens Luxation (ADAMTS17)
Cystinuria Type II-A (SLC3A1)
Neuronal Ceroid Lipofuscinosis 1, NCL 5 (CLN5 Border Collie Variant)
Neuronal Ceroid Lipofuscinosis (CLN8 Australian Shepherd Variant)

Additional Conditions Tested

Y Not Ruskee did not have the variants that we tested for, in the following conditions that the potential effect on dogs with Y Not Ruskee’s breed may not yet be known.

P2Y12 Receptor Platelet Disorder (P2Y12)
Factor IX Deficiency, Hemophilia B (F9 Exon 7, Terrier Variant)
Factor IX Deficiency, Hemophilia B (F9 Exon 7, Rhodesian Ridgeback Variant)
Factor VII Deficiency (F7 Exon 5)
Factor VIII Deficiency, Hemophilia A (F8 Exon 10, Boxer Variant)
Factor VIII Deficiency, Hemophilia A (F8 Exon 11, Shepherd Variant 1)
Factor VIII Deficiency, Hemophilia A (F8 Exon 1, Shepherd Variant 2)
Thrombopathia (RASGRP1 Exon 5, Basset Hound Variant)
Thrombopathia (RASGRP1 Exon 8)
Thrombopathia (RASGRP1 Exon 5, American Eskimo Dog Variant)
Von Willebrand Disease Type II, Type II vWD (VWF Exon 28)
Von Willebrand Disease Type III, Type III vWD (VWF Exon 4)
Von Willebrand Disease Type III, Type III vWD (VWF Exon 7)
Canine Leukocyte Adhesion Deficiency Type III, CLADIII (FERMT3)
Canine Elliptocytosis (SPTB Exon 30)
Glanzmann's Thrombasthenia Type I (ITGA2B Exon 13)
Glanzmann's Thrombasthenia Type I (ITGA2B Exon 12)
May-Hegglin Anomaly (MYH9)
Prekallikrein Deficiency (KLKB1 Exon 8)
Pyruvate Kinase Deficiency (PKLR Exon 5)
Pyruvate Kinase Deficiency (PKLR Exon 7 Labrador Variant)
Pyruvate Kinase Deficiency (PKLR Exon 7 Pug Variant)
Pyruvate Kinase Deficiency (PKLR Exon 7 Beagle Variant)
Pyruvate Kinase Deficiency (PKLR Exon 10)

Additional Conditions Tested

Ligneous Membranitis, LM (PLG)
Congenital Hypothyroidism (TPO, Tenterfield Terrier Variant)
Complement 3 Deficiency, C3 Deficiency (C3)
Severe Combined Immunodeficiency (PRKDC)
Severe Combined Immunodeficiency (RAG1)
X-linked Severe Combined Immunodeficiency (IL2RG Variant 1)
X-linked Severe Combined Immunodeficiency (IL2RG Variant 2)
Progressive Retinal Atrophy, rcd1 (PDE6B Exon 21 Irish Setter Variant)
Progressive Retinal Atrophy, rcd3 (PDE6A)
Progressive Retinal Atrophy, CNGA (CNGA1 Exon 9)
Progressive Retinal Atrophy (CNGB1)
Progressive Retinal Atrophy (SAG)
Golden Retriever Progressive Retinal Atrophy 1, GR-PRA1 (SLC4A3)
Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2 (TTC8)
Progressive Retinal Atrophy, crd1 (PDE6B)
Progressive Retinal Atrophy, crd2 (IQCB1)
Progressive Retinal Atrophy - crd4/cord1 (RPGRIP1)
Day blindness, Cone Degeneration, Achromatopsia (CNGB3 Exon 6)
Achromatopsia (CNGA3 Exon 7 German Shepherd Variant)
Achromatopsia (CNGA3 Exon 7 Labrador Retriever Variant)
Autosomal Dominant Progressive Retinal Atrophy (RHO)
Canine Multifocal Retinopathy (BEST1 Exon 2)
Canine Multifocal Retinopathy (BEST1 Exon 5)
Canine Multifocal Retinopathy (BEST1 Exon 10 Deletion)

Additional Conditions Tested

Canine Multifocal Retinopathy (BEST1 Exon 10 SNP)
Glaucoma (ADAMTS10 Exon 9)
Glaucoma (ADAMTS10 Exon 17)
Glaucoma (ADAMTS17 Exon 11)
Hereditary Cataracts, Early-Onset Cataracts, Juvenile Cataracts (HSF4 Exon 9 Boston Terrier Variant)
Congenital Stationary Night Blindness (RPE65)
2,8-Dihydroxyadenine Urolithiasis, 2,8-DHA Urolithiasis (APRT)
Cystinuria Type I-A (SLC3A1)
Cystinuria Type II-B (SLC7A9)
Hyperuricosuria and Hyperuricemia or Urolithiasis, HUU (SLC2A9)
Polycystic Kidney Disease, PKD (PKD1)
Primary Hyperoxaluria (AGXT)
Protein Losing Nephropathy, PLN (NPHS1)
X-Linked Hereditary Nephropathy, XLHN (COL4A5 Exon 35, Samoyed Variant 2)
Autosomal Recessive Hereditary Nephropathy, Familial Nephropathy, ARHN (COL4A4 Exon 3)
Primary Ciliary Dyskinesia, PCD (CCDC39 Exon 3)
Congenital Keratoconjunctivitis Sicca and Ichthyosiform Dermatosis, Dry Eye Curly Coat Syndrome, CKCSID (FAM83H Exon 5)
X-linked Ectodermal Dysplasia, Anhidrotic Ectodermal Dysplasia (EDA Intron 8)
Renal Cystadenocarcinoma and Nodular Dermatofibrosis, RCND (FLCN Exon 7)
Canine Fucosidosis (FUCA1)
Glycogen Storage Disease Type II, Pompe's Disease, GSD II (GAA)
Glycogen Storage Disease Type IA, Von Gierke Disease, GSD IA (G6PC)
Glycogen Storage Disease Type IIIA, GSD IIIA (AGL)
Mucopolysaccharidosis Type IIIA, Sanfilippo Syndrome Type A, MPS IIIA (SGSH Exon 6 Variant 1)

Additional Conditions Tested

Mucopolysaccharidosis Type IIIA, Sanfilippo Syndrome Type A, MPS IIIA (SGSH Exon 6 Variant 2)
Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 5)
Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 3)
Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency (PFKM Whippet and English Springer Spaniel Variant)
Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency (PFKM Wachtelhund Variant)
Lagotto Storage Disease (ATG4D)
Neuronal Ceroid Lipofuscinosis 1, NCL 1 (PPT1 Exon 8)
Neuronal Ceroid Lipofuscinosis 2, NCL 2 (TPP1 Exon 4)
Neuronal Ceroid Lipofuscinosis 1, Cerebellar Ataxia, NCL4A (ARSG Exon 2)
Neuronal Ceroid Lipofuscinosis 6, NCL 6 (CLN6 Exon 7)
Neuronal Ceroid Lipofuscinosis 8, NCL 8 (CLN8 English Setter Variant)
Neuronal Ceroid Lipofuscinosis (MFSD8)
Neuronal Ceroid Lipofuscinosis 10, NCL 10 (CTSD Exon 5)
Neuronal Ceroid Lipofuscinosis (CLN5 Golden Retriever Variant)
Adult-Onset Neuronal Ceroid Lipofuscinosis (ATP13A2, Tibetan Terrier Variant)
GM1 Gangliosidosis (GLB1 Exon 15 Shiba Inu Variant)
GM1 Gangliosidosis (GLB1 Exon 15 Alaskan Husky Variant)
GM1 Gangliosidosis (GLB1 Exon 2)
GM2 Gangliosidosis (HEXB, Poodle Variant)
GM2 Gangliosidosis (HEXA)
Globoid Cell Leukodystrophy, Krabbe disease (GALC Exon 5)
Autosomal Recessive Amelogenesis Imperfecta, Familial Enamel Hypoplasia (Italian Greyhound Variant)
Persistent Mullerian Duct Syndrome, PMDS (AMHR2)
Alaskan Husky Encephalopathy, Subacute Necrotizing Encephalomyelopathy (SLC19A3)

Additional Conditions Tested

Alexander Disease (GFAP)
Cerebellar Abiotrophy, Neonatal Cerebellar Cortical Degeneration, NCCD (SPTBN2)
Cerebellar Ataxia, Progressive Early-Onset Cerebellar Ataxia (SEL1L)
Cerebellar Hypoplasia (VLDLR)
Spinocerebellar Ataxia, Late-Onset Ataxia, LoSCA (CAPN1)
Spinocerebellar Ataxia with Myokymia and/or Seizures (KCNJ10)
Benign Familial Juvenile Epilepsy, Remitting Focal Epilepsy (LGI2)
Degenerative Myelopathy, DM (SOD1A)
Fetal-Onset Neonatal Neuroaxonal Dystrophy (MFN2)
Hypomyelination and Tremors (FNIP2)
Shaking Puppy Syndrome, X-linked Generalized Tremor Syndrome (PLP)
L-2-Hydroxyglutaricaciduria, L2HGA (L2HGDH)
Neonatal Encephalopathy with Seizures, NEWS (ATF2)
Polyneuropathy, NDRG1 Greyhound Variant (NDRG1 Exon 15)
Polyneuropathy, NDRG1 Malamute Variant (NDRG1 Exon 4)
Narcolepsy (HCRTR2 Intron 6)
Progressive Neuronal Abiotrophy, Canine Multiple System Degeneration, CMSD (SERAC1 Exon 15)
Progressive Neuronal Abiotrophy, Canine Multiple System Degeneration, CMSD (SERAC1 Exon 4)
Dilated Cardiomyopathy, DCM1 (PDK4)
Dilated Cardiomyopathy, DCM2 (TTN)
Long QT Syndrome (KCNQ1)
Muscular Dystrophy (DMD, Cavalier King Charles Spaniel Variant 1)
Muscular Dystrophy (DMD Pembroke Welsh Corgi Variant )
Muscular Dystrophy (DMD Golden Retriever Variant)

Additional Conditions Tested

Exercise-Induced Collapse (DNM1)
Inherited Myopathy of Great Danes (BIN1)
Myotonia Congenita (CLCN1 Exon 7)
Myotonia Congenita (CLCN1 Exon 23)
Myotubular Myopathy 1, X-linked Myotubular Myopathy, XL-MTM (MTM1, Labrador Variant)
Hypocatalasia, Acatalasemia (CAT)
Pyruvate Dehydrogenase Deficiency (PDP1)
Malignant Hyperthermia (RYR1)
Imerslund-Grasbeck Syndrome, Selective Cobalamin Malabsorption (CUBN Exon 53)
Imerslund-Grasbeck Syndrome, Selective Cobalamin Malabsorption (CUBN Exon 8)
Congenital Myasthenic Syndrome (CHAT)
Congenital Myasthenic Syndrome (COLQ)
Episodic Falling Syndrome (BCAN)
Dystrophic Epidermolysis Bullosa (COL7A1)
Ectodermal Dysplasia, Skin Fragility Syndrome (PKP1)
Ichthyosis, Epidermolytic Hyperkeratosis (KRT10)
Ichthyosis (PNPLA1)
Ichthyosis (SLC27A4)
Focal Non-Epidermolytic Palmoplantar Keratoderma, Pachyonychia Congenita (KRT16)
Hereditary Footpad Hyperkeratosis (FAM83G)
Hereditary Nasal Parakeratosis (SUV39H2)
Musladin-Lueke Syndrome (ADAMTSL2)
Cleft Lip and/or Cleft Palate (ADAMTS20)
Hereditary Vitamin D-Resistant Rickets (VDR)

Additional Conditions Tested

Osteogenesis Imperfecta, Brittle Bone Disease (COL1A2)
Osteogenesis Imperfecta, Brittle Bone Disease (SERPINH1)
Osteogenesis Imperfecta, Brittle Bone Disease (COL1A1)
Osteochondrodysplasia, Skeletal Dwarfism (SLC13A1)
Skeletal Dysplasia 2, SD2 (COL11A2)
Chondrodystrophy and Intervertebral Disc Disease, CDDY/IVDD, Type I IVDD (FGF4 retrogene - CFA12)

Genetic Diversity and Inbreeding

Coefficient of Inbreeding (COI)

Genetic Result:
5%

Our genetic COI measures the proportion of your dog’s genome (her genes) where the genes on the mother’s side are identical by descent to those on the father’s side. The higher your dog’s coefficient of inbreeding (the percentage), the more inbred your dog is.

Your Dog’s COI

Coefficient of inbreeding chart

This graph represents where your dog’s inbreeding levels fall on a scale compared to both dogs with a similar breed makeup to her (the yellow dotted line) and all purebred dogs (the grey line).

Genetic Diversity and Inbreeding

More on the Science

Embark scientists, along with our research partners at Cornell University, have shown the impact of inbreeding on longevity and fertility and developed a state-of-the-art, peer-reviewed method for accurately measuring COI and predicting average COI in litters.

Citations

About Embark

Embark Veterinary is a canine genetics company offering research-grade genetic tests to pet owners and breeders. Every Embark test examines over 200,000 genetic markers, and provides results for over 170 genetic health conditions, breed identification, clinical tools, and more.

Embark is a research partner of the Cornell University College of Veterinary Medicine and collaborates with scientists and registries to accelerate genetic research in canine health. We make it easy for customers and vets to understand, share and make use of their dog’s unique genetic profile to improve canine health and happiness.

Learn more at embarkvet.com

Veterinarians and hospitals can send inquiries to veterinarians@embarkvet.com.