Straight Shot's All American Patriot inherited one copy of the variant we tested for Exercise-Induced Collapse, EIC
This variant should not impact Riot’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Riot is unlikely to develop this condition due to this variant because he only has one copy of the variant.
Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.
EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.
Signs develop in juvenile dogs, typically before 3 years of age.
Genetic testing, clinical signs, and muscle biopsy can be used to diagnose this disorder.
Dogs with this condition are otherwise normal and healthy, though some severely affected dogs have died during an episode. The factors determining the severity of an episode on a given day or in a given dog is unknown.
- Minimizing or eliminating intense exercise is the best way we currently know to prevent complications from this condition.