Riot
Veterinary Report by Embark
embarkvet.com
Test Date: May 5th, 2022
Customer-supplied information
Owner Name: Breaanna Foight
Dog Name: Riot
Sex:
Male
(intact)
Date of birth:
12/24/21
Breed type: N/A
Breed: English Labrador Retriever
Breed registration: American Kennel Club (AKC) SS31659906
Microchip: N/A
Genetic summary
Genetic breed identification:
Labrador Retriever
Breed ancestry:
Labrador Retriever: 100.0%Predicted adult weight: 70 lbs
Calculated from 17 size genes.
Life stage: Puppy
Based on date of birth provided.
Clinical Tools
These clinical genetic tools can inform clinical decisions and diagnoses. These tools do not predict increased risk for disease.
Alanine Aminotransferase Activity (GPT)
Riot's baseline ALT level is likely to be Normal
Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.
Genetic testing is the only way to provide your veterinarian with this clinical tool.
Veterinarians may recommend blood work to establish a baseline ALT value for healthy dogs with one or two copies of this variant.
Health Report
If Riot inherited any of the variants that we tested, they will be listed at the top of the Health Report section, along with a description of how to interpret this result. We also include all of the variants that we tested Riot for that we did not detect the risk variant for.
A genetic test is not a diagnosisThis genetic test does not diagnose a disease. Please talk to your vet about your dog’s genetic results, or if you think that your pet may have a health condition or disease.
Riot inherited one variant that you should learn more about.
Exercise-Induced Collapse, EIC
Breed-Relevant Genetic Conditions 16 variants not detected
Additional Genetic Conditions 213 variants not detected
Health Report
Exercise-Induced Collapse, EIC (DNM1)
Straight Shot's All American Patriot inherited one copy of the variant we tested
This result should not impact Riot’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.
Your dog carries this variant and will pass it on to ~50% of his offspring.
EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.
Signs develop in juvenile dogs, typically before 3 years of age.
Genetic testing, clinical signs, and muscle biopsy can be used to diagnose this disorder.
Dogs with this condition are otherwise normal and healthy, though some severely affected dogs have died during an episode. The factors determining the severity of an episode on a given day or in a given dog is unknown.
- Minimizing or eliminating intense exercise is the best way we currently know to prevent complications from this condition.
Breed-Relevant Conditions Tested
Riot did not have the variants that we tested for, that are relevant to his breed:
Additional Conditions Tested
Riot did not have the variants that we tested for, in the following conditions that the potential effect on dogs with Riot’s breed may not yet be known.
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Genetic Diversity and Inbreeding
Coefficient of Inbreeding (COI)
- Genetic Result:
- 19%
Our genetic COI measures the proportion of your dog’s genome (his genes) where the genes on the mother’s side are identical by descent to those on the father’s side. The higher your dog’s coefficient of inbreeding (the percentage), the more inbred your dog is.
Your Dog’s COI
This graph represents where your dog’s inbreeding levels fall on a scale compared to both dogs with a similar breed makeup to him (the blue bars) and all purebred dogs (the grey line).
Genetic Diversity and Inbreeding
More on the Science
Embark scientists, along with our research partners at Cornell University, have shown the impact of inbreeding on longevity and fertility and developed a state-of-the-art, peer-reviewed method for accurately measuring COI and predicting average COI in litters.
- Sams & Boyko 2019 "Fine-Scale Resolution of Runs of Homozygosity Reveal Patterns of Inbreeding and Substantial Overlap with Recessive Disease Genotypes in Domestic Dogs"
- Chu et al 2019 "Inbreeding depression causes reduced fecundity in Golden Retrievers"
- Yordy et al 2019 "Body size, inbreeding, and lifespan in domestic dogs"
About Embark
Embark Veterinary is a canine genetics company offering research-grade genetic tests to pet owners and breeders. Every Embark test examines over 200,000 genetic markers, and provides results for over 230 genetic health conditions, breed identification, clinical tools, and more.
Embark is a research partner of the Cornell University College of Veterinary Medicine and collaborates with scientists and registries to accelerate genetic research in canine health. We make it easy for customers and vets to understand, share and make use of their dog’s unique genetic profile to improve canine health and happiness.
Learn more at embarkvet.com
Veterinarians and hospitals can send inquiries to veterinarians@embarkvet.com.