Gunner
Veterinary Report by Embark
embarkvet.com
Test Date: January 9th, 2020
Customer-supplied information
Owner Name: Shane Prather
Dog Name: Gunner
Sex:
Male
(intact)
Date of birth:
06/26/18
Breed type: N/A
Breed: Labrador Retriever
Breed registration: American Kennel Club (AKC) SS06762905
Microchip: N/A
Genetic summary
Genetic breed identification:
Labrador Retriever
Breed ancestry:
Labrador Retriever: 100.0%Predicted adult weight: 59 lbs
Calculated from 17 size genes.
Life stage: Mature adult
Based on date of birth provided.
Clinical Tools
These clinical genetic tools can inform clinical decisions and diagnoses. These tools do not predict increased risk for disease.
Alanine Aminotransferase Activity (GPT)
Gunner's baseline ALT level is likely to be Normal
Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.
Genetic testing is the only way to provide your veterinarian with this clinical tool.
Veterinarians may recommend blood work to establish a baseline ALT value for healthy dogs with one or two copies of this variant.
Health Report
If Gunner inherited any of the variants that we tested, they will be listed at the top of the Health Report section, along with a description of how to interpret this result. We also include all of the variants that we tested Gunner for that we did not detect the risk variant for.
A genetic test is not a diagnosisThis genetic test does not diagnose a disease. Please talk to your vet about your dog’s genetic results, or if you think that your pet may have a health condition or disease.
Gunner inherited one variant that you should learn more about.
Progressive Retinal Atrophy, prcd
Breed-Relevant Genetic Conditions 15 variants not detected
Additional Genetic Conditions 179 variants not detected
Health Report
Progressive Retinal Atrophy, prcd (PRCD Exon 1)
Red Raider Lab's Gunner inherited one copy of the variant we tested
This result should not impact Gunner’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.
Your dog carries this variant and will pass it on to ~50% of his offspring.
PRA-prcd is a retinal disease that causes progressive, non-painful vision loss. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of rod cells, leading to night blindness before day blindness.
The age affected dogs will first show signs of visual impairment varies by breed. However, most begin showing clinical signs in early adulthood.
Veterinarians use a focused light to examine the pupils. In affected dogs, the pupils will appear more dilated and slower to contract. Your vet may also use a lens to visualize the retina at the back of the eye to look for changes in the optic nerve or blood vessels. You may be referred to a veterinary ophthalmologist for a definitive diagnosis.
Currently, there is no definitive treatment for PRA. Supplements, including antioxidants, have been proposed for management of the disease, but have not been scientifically proven effective.
- Careful monitoring by your veterinarian will be required for the rest of your affected dog's life as secondary complications, including cataracts, can develop.
- With blind dogs, keeping furniture in the same location, making sure they are on a leash in unfamiliar territory, and training them to understand verbal commands are some of the ways to help them at home.
Breed-Relevant Conditions Tested
Gunner did not have the variants that we tested for, that are relevant to his breed:
Additional Conditions Tested
Gunner did not have the variants that we tested for, in the following conditions that the potential effect on dogs with Gunner’s breed may not yet be known.
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Additional Conditions Tested
Genetic Diversity and Inbreeding
Coefficient of Inbreeding (COI)
- Genetic Result:
- 11%
Our genetic COI measures the proportion of your dog’s genome (his genes) where the genes on the mother’s side are identical by descent to those on the father’s side. The higher your dog’s coefficient of inbreeding (the percentage), the more inbred your dog is.
Your Dog’s COI
This graph represents where your dog’s inbreeding levels fall on a scale compared to both dogs with a similar breed makeup to him (the blue bars) and all purebred dogs (the grey line).
Genetic Diversity and Inbreeding
More on the Science
Embark scientists, along with our research partners at Cornell University, have shown the impact of inbreeding on longevity and fertility and developed a state-of-the-art, peer-reviewed method for accurately measuring COI and predicting average COI in litters.
- Sams & Boyko 2019 "Fine-Scale Resolution of Runs of Homozygosity Reveal Patterns of Inbreeding and Substantial Overlap with Recessive Disease Genotypes in Domestic Dogs"
- Chu et al 2019 "Inbreeding depression causes reduced fecundity in Golden Retrievers"
- Yordy et al 2019 "Body size, inbreeding, and lifespan in domestic dogs"
About Embark
Embark Veterinary is a canine genetics company offering research-grade genetic tests to pet owners and breeders. Every Embark test examines over 200,000 genetic markers, and provides results for over 230 genetic health conditions, breed identification, clinical tools, and more.
Embark is a research partner of the Cornell University College of Veterinary Medicine and collaborates with scientists and registries to accelerate genetic research in canine health. We make it easy for customers and vets to understand, share and make use of their dog’s unique genetic profile to improve canine health and happiness.
Learn more at embarkvet.com
Veterinarians and hospitals can send inquiries to veterinarians@embarkvet.com.