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Tasha inherited one copy of the variant we tested
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Place of Birth
Russia, Moscow Oblast, Russia
Current Location
Long Prairie, MN, USA
From
Russia
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Health Summary
Tasha inherited one variant that you should learn more about.
And one variant that you should tell your vet about.
Progressive Retinal Atrophy, crd4/cord1
What does this result mean?
This variant should not impact Tasha’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Tasha is unlikely to develop this condition due to this variant because she only has one copy of the variant.
Impact on Breeding
Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.
What is Progressive Retinal Atrophy, crd4/cord1?
PRA-CRD4/cord1 is a retinal disease that causes progressive, non-painful vision loss over a 1-2 year period. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of cone cells, causing day blindness before night blindness.
ALT Activity
Tasha inherited one copy of the variant we tested
Why is this important to your vet?
Tasha has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Tasha has this genotype, as ALT is often used as an indicator of liver health and Tasha is likely to have a lower than average resting ALT activity. As such, an increase in Tasha’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.
What is ALT Activity?
Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.
Breed-Relevant Genetic Conditions
6 variants not detected
Mucopolysaccharidosis Type IIIA, Sanfilippo Syndrome Type A, MPS IIIA (SGSH Exon 6, Dachshund Variant)
Identified in Dachshunds
Variant not detected
Neuronal Ceroid Lipofuscinosis 1, NCL 1 (PPT1 Exon 8, Dachshund Variant 1)
Identified in Dachshunds
Variant not detected
Neuronal Ceroid Lipofuscinosis 2, NCL 2 (TPP1 Exon 4, Dachshund Variant 2)
Identified in Dachshunds
Variant not detected
Narcolepsy (HCRTR2 Exon 1, Dachshund Variant)
Identified in Dachshunds
Variant not detected
Osteogenesis Imperfecta (SERPINH1, Dachshund Variant)
Identified in Dachshunds
Variant not detected
Intervertebral Disc Disease (Type I) (FGF4 retrogene - CFA12)
Identified in Dachshunds
Variant not detected
Additional Genetic Conditions
205 variants not detected
