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Yankee

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“Medium blue F1b Labradoodle.”

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@mulemountaindoodles

Place of Birth

Mesa, AZ, USA

Current Location

Phoenix, AZ, USA

From

Mesa, AZ, USA

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Genetic Stats

Predicted Adult Weight

34 lbs

Genetic Age
38 human years

Based on the date of birth provided

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Health Summary

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Yankee is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Intervertebral Disc Disease (Type I)

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Yankee inherited one copy of the variant we tested

How to interpret this result

Yankee has one copy of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Dilated Cardiomyopathy, DCM2

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Yankee inherited one copy of the variant we tested

What does this result mean?

Research indicates that this genetic variant is not likely to increase the risk that Yankee will develop this condition.

Scientific Basis

Dogs with Yankee’s breeds have been included in research studies or have had follow-up by our experts that indicate that this genetic variant is not likely to increase the risk of Yankee developing clinical disease.

Impact on Breeding

This genetic result should not be the primary factor in your breeding decisions.

What is Dilated Cardiomyopathy, DCM2?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

Breed-Relevant Genetic Conditions

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Hemophilia A (F8 Exon 10, Boxer Variant)

Identified in Boxers

Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in Standard Poodles and Small Poodles

Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Cocker Spaniels, Standard Poodles, and more

Progressive Retinal Atrophy, crd1 (PDE6B, American Staffordshire Terrier Variant)

Identified in American Staffordshire Terriers

Urate Kidney & Bladder Stones (SLC2A9)

Identified in American Staffordshire Terriers

Familial Nephropathy (COL4A4 Exon 3, Cocker Spaniel Variant)

Identified in Cocker Spaniels

Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency (PFKM, Whippet and English Springer Spaniel Variant)

Identified in Cocker Spaniels

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A (ARSG Exon 2, American Staffordshire Terrier Variant)

Identified in American Staffordshire Terriers

GM2 Gangliosidosis (HEXB, Poodle Variant)

Identified in Standard Poodles and Small Poodles

Degenerative Myelopathy, DM (SOD1A)

Identified in Boxers and Standard Poodles

L-2-Hydroxyglutaricaciduria, L2HGA (L2HGDH, Staffordshire Bull Terrier Variant)

Identified in American Staffordshire Terriers

Neonatal Encephalopathy with Seizures, NEWS (ATF2)

Identified in Standard Poodles and Small Poodles

Acral Mutilation Syndrome (GDNF-AS, Spaniel and Pointer Variant)

Identified in Cocker Spaniels

Exercise-Induced Collapse, EIC (DNM1)

Identified in Cocker Spaniels

Osteochondrodysplasia (SLC13A1, Poodle Variant)

Identified in Standard Poodles and Small Poodles

Additional Genetic Conditions

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