Yankee inherited one copy of the variant we tested
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“Medium blue F1b Labradoodle.”
Instagram tag
@mulemountaindoodles
Place of Birth
Mesa, AZ, USA
Current Location
Phoenix, AZ, USA
From
Mesa, AZ, USA
This dog has been viewed and been given 2 wags
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Health Summary
Yankee is at increased risk for one genetic health condition.
And inherited one variant that you should learn more about.
Intervertebral Disc Disease (Type I)
How to interpret this result
Yankee has one copy of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.
What is Intervertebral Disc Disease (Type I)?
Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.
Dilated Cardiomyopathy, DCM2
Yankee inherited one copy of the variant we tested
What does this result mean?
Research indicates that this genetic variant is not likely to increase the risk that Yankee will develop this condition.
Scientific Basis
Dogs with Yankee’s breeds have been included in research studies or have had follow-up by our experts that indicate that this genetic variant is not likely to increase the risk of Yankee developing clinical disease.
Impact on Breeding
This genetic result should not be the primary factor in your breeding decisions.
What is Dilated Cardiomyopathy, DCM2?
DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.
Breed-Relevant Genetic Conditions
Hemophilia A (F8 Exon 10, Boxer Variant)
Identified in Boxers
Variant not detected
Von Willebrand Disease Type I, Type I vWD (VWF)
Identified in Standard Poodles and Small Poodles
Variant not detected
Progressive Retinal Atrophy, prcd (PRCD Exon 1)
Identified in Cocker Spaniels, Standard Poodles, and more
Variant not detected
Progressive Retinal Atrophy, crd1 (PDE6B, American Staffordshire Terrier Variant)
Identified in American Staffordshire Terriers
Variant not detected
Urate Kidney & Bladder Stones (SLC2A9)
Identified in American Staffordshire Terriers
Variant not detected
Familial Nephropathy (COL4A4 Exon 3, Cocker Spaniel Variant)
Identified in Cocker Spaniels
Variant not detected
Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency (PFKM, Whippet and English Springer Spaniel Variant)
Identified in Cocker Spaniels
Variant not detected
Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A (ARSG Exon 2, American Staffordshire Terrier Variant)
Identified in American Staffordshire Terriers
Variant not detected
GM2 Gangliosidosis (HEXB, Poodle Variant)
Identified in Standard Poodles and Small Poodles
Variant not detected
Degenerative Myelopathy, DM (SOD1A)
Identified in Boxers and Standard Poodles
Variant not detected
L-2-Hydroxyglutaricaciduria, L2HGA (L2HGDH, Staffordshire Bull Terrier Variant)
Identified in American Staffordshire Terriers
Variant not detected
Neonatal Encephalopathy with Seizures, NEWS (ATF2)
Identified in Standard Poodles and Small Poodles
Variant not detected
Acral Mutilation Syndrome (GDNF-AS, Spaniel and Pointer Variant)
Identified in Cocker Spaniels
Variant not detected
Exercise-Induced Collapse, EIC (DNM1)
Identified in Cocker Spaniels
Variant not detected
Osteochondrodysplasia (SLC13A1, Poodle Variant)
Identified in Standard Poodles and Small Poodles
Variant not detected
Additional Genetic Conditions
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What is a linkage test?
DNA sequences that are close together on a chromosome tend to be inherited together. Because of this, we can use genetic variation surrounding a specific variant (i.e. "linked" to it) to infer the presence or absence of a variant that is associated with a health condition or trait.
Linkage tests are not as predictive of your dog’s true genotype as direct assays, which we use on most other genetic conditions we test for.
Traits
Explore the genetics behind your dog’s appearance and size.
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Coat Color
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Coat Traits
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Body Features
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Body Size
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.