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“Xoran”
Xandramani van de Bremmen EC-2008

Afghan Hound

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“Xoran won the 2008 European Oval Track Racing Championships. http://www.afghanhoundpedigrees.com/details.php?id=149368”

Place of Birth

Netherlands

Current Location

California, USA

From

Netherlands

This dog has been viewed and been given 7 wags

Registration

N/A :

Genetic Breed Result

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Afghan Hound

The Afghan Hound is a head-turning dog that is as old as they come. These dogs are a sight to behold when reaching top speed with all that hair blowing in the wind. They can make devoted companions with solid but gentle training

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Changes to this dog’s profile
  • On 8/14/2018 changed name from "Xoran" to "Xandramani van de Bremmen"

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Health Summary

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Xoran inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Degenerative Myelopathy, DM

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Xoran inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Xoran is unlikely to develop this condition due to the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Xoran inherited one copy of the variant we tested

Why is this important to your vet?

Xoran has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Xoran has this genotype, as ALT is often used as an indicator of liver health and Xoran is likely to have a lower than average resting ALT activity. As such, an increase in Xoran’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Additional Genetic Conditions

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Coat Color

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Through Xoran’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

D

Haplotype

D4

Map

D

Xandramani van de Bremmen’s Haplogroup

D is a rare maternal line, which may be the result of an ancient dog breeding with another canid, possibly a wolf. It is found in Afghan Hounds and Scandinavian dog breeds.

D4

Xandramani van de Bremmen’s Haplotype

A member of the small D haplogroup, this rare haplotype occurs in Afghan Hounds.

Some other Embark dogs with this haplotype:

Afghan Hounds are one of few breeds that descends from this rare maternal line.

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Through Xoran’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

D

Haplotype

H7

Map

D

Xandramani van de Bremmen’s Haplogroup

The D paternal lineage is very common in well-known populations of dogs. Breeds belonging to the D lineage likely have direct male ancestors that can be traced all the way back to the origin of domestic dogs themselves! One popular breed that commonly sports a D lineage is the Boxer. Boxers were developed in the late 19th century from Mastiff dogs, so it is no surprise that D is well represented among Mastiffs, Bulldogs, as well as Terriers. Intriguingly, D is also found among Lhasa Apsos, an ancient Tibetan breed, and Afghan Hounds. While the presence of this lineage in Polynesia or the New World can be chalked up to interbreeding with European dogs brought during voyages of discovery or later settlement, D is also well represented among village dog populations in the Middle East and Africa. If the fact that we find dogs bearing a D lineage in the Middle East (not to mention the large amount of diversity among Middle Eastern D lineage males) is any indication of ancient residence in that region, then the presence among Oceanian village dogs is peculiar. Rather, it may be that D is part of a broader Eurasian group of ancient paternal lineages which disappeared from the eastern portion of its original range, persisting in the island of New Guinea as well as West Asia and Africa. With the rise of Mastiff breeds, the D lineage received a new life as it became common among many types of working dogs.

H7

Xandramani van de Bremmen’s Haplotype

Part of the D haplogroup, this common haplotype has been found in French Bulldogs, Afghan Hounds, Bull Terriers, and village dogs spanning from South America to Africa and into the South Pacific.

Some other Embark dogs with this haplotype:

The D paternal lineage is common in Boxers.

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