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“BunBun”
Witzn Wild Times

Sealyham Terrier

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“Always BunBun”

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Registration

American Kennel Club (AKC): RN35695504
Microchip: 985141003246795

Genetic Breed Result

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Sealyham Terrier

Sealyham Terriers are a unique looking terrier from Wales. With their mustache and prominent eyebrows, they are truly unmistakable little dogs!

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Changes to this dog’s profile
  • On 1/26/2021 changed handle from "witznbunbun" to "witznwildtimes"
  • On 1/26/2021 changed name from "Witzn zBD BunBun" to "Witzn Wild Times"
  • On 1/19/2021 changed handle from "witzntbdbunbun" to "witznbunbun"
  • On 1/19/2021 changed name from "Wwitzn TBD BunBun" to "Witzn zBD BunBun"
  • On 1/13/2021 changed name from "Witzn TBD BunBun" to "Wwitzn TBD BunBun"

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Health Summary

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BunBun is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Intervertebral Disc Disease (Type I)

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BunBun inherited one copy of the variant we tested

What does this result mean?

Follow-up by our experts indicates that this genetic variant is associated with an increase to BunBun’s risk for developing Intervertebral Disc Disease (Type I).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to BunBun have not yet been the focus of research studies, our data indicates that BunBun is likely to be at increased risk.

Impact on Breeding

While further investigation is warranted to determine the clinical presentation and penetrance in BunBun’s breed, we recommend taking this genetic result into account when making breeding decisions.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Dilated Cardiomyopathy, DCM2

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BunBun inherited one copy of the variant we tested

What does this result mean?

Research indicates that this genetic variant is not likely to increase the risk that BunBun will develop this condition.

Scientific Basis

Dogs with BunBun’s breed have been included in research studies or have had follow-up by our experts that indicate that this genetic variant is not likely to increase the risk of BunBun developing clinical disease.

Impact on Breeding

This genetic result should not be the primary factor in your breeding decisions.

What is Dilated Cardiomyopathy, DCM2?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

ALT Activity

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BunBun inherited one copy of the variant we tested

Why is this important to your vet?

BunBun has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that BunBun has this genotype, as ALT is often used as an indicator of liver health and BunBun is likely to have a lower than average resting ALT activity. As such, an increase in BunBun’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Primary Lens Luxation (ADAMTS17)

Identified in Sealyham Terriers

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through BunBun’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B81

Map

B1

Witzn Wild Times’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B81

Witzn Wild Times’s Haplotype

Part of the large B1 haplogroup, this haplotype occurs most frequently in Shih Tzus, Chihuahuas, and Poodles.

Some other Embark dogs with this haplotype:

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that BunBun inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since BunBun is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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