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Winston Bear

Murray River Retriever

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“Winston Bear was rescued from a pet shop and he ended up with numerous genetic health issues. Apart from that he is a 5 year old who still thinks he is a pup, very loving, playful and loyal. He is also fiercely protective of his family. He is nervous around other dogs and strangers however has bonded very well with our 8 year old dog of same breed.”

Current Location

Ballarat, Victoria, Australia

From

Teesdale VIC, Australia

This dog has been viewed and been given 3 wags

Registration

N/A : 001

Genetic Breed Result

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Murray River Retriever

The Murray River Retriver is an energetic, loyal, and intelligent breed developed in the 19th century by duck hunters in Australia. The breed's happy and sociable attitude make it a great companion dog.

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Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain Winston Bear’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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Winston Bear is at increased risk for one genetic health condition.

And inherited three variants that you should learn more about.

Intervertebral Disc Disease (Type I)

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Winston Bear inherited both copies of the variant we tested

What does this result mean?

Our research indicates that this genetic variant is likely to increase the risk that Winston Bear will develop this disease.

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Winston Bear have not yet been the focus of research studies, our data indicates that Winston Bear is likely to be at increased risk.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Exercise-Induced Collapse, EIC

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Winston Bear inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Winston Bear is unlikely to develop this condition due to the variant.

What is Exercise-Induced Collapse, EIC?

EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.

Bald Thigh Syndrome

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Winston Bear inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Winston Bear is unlikely to develop this condition due to the variant.

What is Bald Thigh Syndrome?

A cosmetic condition common to sighthounds characterized by hair loss on the thighs. It is caused by a structural abnormality of the hair follicle.

ALT Activity

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Winston Bear inherited both copies of the variant we tested

Why is this important to your vet?

Winston Bear has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Winston Bear's ALT activity above their current, healthy, ALT activity. As an increase above Winston Bear’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Additional Genetic Conditions

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Traits

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Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

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Other Coat Traits

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Other Body Features

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Body Size

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Through Winston Bear’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B95

Map

B1

Winston Bear’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B95

Winston Bear’s Haplotype

Part of the B1 haplogroup, we see this haplotype most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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Through Winston Bear’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.6

Map

A1a

Winston Bear’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.6

Winston Bear’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs in Labrador Retrievers, Basset Hounds, and Leonbergers, and village dogs in Fiji.

Some other Embark dogs with this haplotype:

Dogs with A1a lineage travelled during European Colonial times.

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