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“Ripple”
Vivant et Lisse Legacy's Timeless Current

Belgian Shepherd

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“Drama Queen and counter surfer to the max”

Current Location

Phoenix, AZ, USA

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Registration

American Kennel Club (AKC): DN51989503

Genetic Breed Result

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Belgian Tervuren

The Belgian Tervuren is one of the four varieties of Belgian Shepherd, though the AKC distinguishes them as their own breed. This active working dog is renowned for its intelligence and drive. If given the opportunity for plenty of physical and mental exercise, the Belgian Tervuren will astound you with its athleticism and versatility.

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DNA Breed Origins

Breed colors:
Belgian Tervuren

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Health Summary

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Ripple inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Dilated Cardiomyopathy, DCM1

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Ripple inherited one copy of the variant we tested

What does this result mean?

Research indicates that this genetic variant is not likely to increase the risk that Ripple will develop this condition.

Scientific Basis

Dogs with Ripple’s breed have been included in research studies or have had follow-up by our experts that indicate that this genetic variant is not likely to increase the risk of Ripple developing clinical disease.

Impact on Breeding

This genetic result should not be the primary factor in your breeding decisions.

What is Dilated Cardiomyopathy, DCM1?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

ALT Activity

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Ripple inherited one copy of the variant we tested

Why is this important to your vet?

Ripple has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Ripple has this genotype, as ALT is often used as an indicator of liver health and Ripple is likely to have a lower than average resting ALT activity. As such, an increase in Ripple’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 3, German Shepherd Variant)

Identified in Belgian Shepherds and Belgian Tervurens

Spongy Degeneration with Cerebellar Ataxia 1 (KCNJ10)

Identified in Belgian Shepherds and Belgian Tervurens

Spongy Degeneration with Cerebellar Ataxia 2 (ATP1B2)

Identified in Belgian Shepherds and Belgian Tervurens

Additional Genetic Conditions

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Through Ripple’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A11a

Map

A1d

Vivant et Lisse Legacy's Timeless Current’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A11a

Vivant et Lisse Legacy's Timeless Current’s Haplotype

Part of the large A1d haplogroup, this common haplotype occurs in village dogs all over the world. Among the 23 breeds we have sampled it in, the most common occurrences include Rottweilers, English Setters, English Springer Spaniels, and wirehaired pointing griffons.

Some other Embark dogs with this haplotype:

The vast majority of Rottweilers have the A1d haplogroup.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Ripple inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Ripple is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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