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“Persia”
Vallecito's Jewel of Persia

Mixed Ancestry

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Place of Birth

DireWolf Dogs of Vallecito, LLC, Washington 25, Fruitland, WA, USA

Current Location

DireWolf Dogs of Vallecito, LLC, Washington 25, Fruitland, WA, USA

From

DireWolf Dogs of Vallecito, LLC, Washington 25, Fruitland, WA, USA

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Registration

National American Alsatian Registry: SC4001-2

Genetic Breed Result

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Alaskan Malamute

The Alaskan Malamute is a large, fluffy spitz breed recognized as being one of the most ancient breeds of dogs. The forebears to the modern Malamute crossed the Bering Strait with their owners over 4,000 years ago. Their size, thick coat, and work drive make them ideal dogs for pulling sleds, but they also make amicable companions.

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German Shepherd Dog

German Shepherds are confident, courageous dogs with a keen sense of smell and notable intelligence. These are active working dogs who excel at many canine sports and tasks -- they are true utility dogs! Their versatility combined with their loyal companionship has them consistently listed as one of the most popular breeds in the United States.

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Irish Wolfhound

The Irish Wolfhound is about as big as they come. These gentle giants have served as hunting dogs for thousands of years. They make wonderful companions, especially for kids.

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Akita

The Akita is a large breed of dog originating from the mountainous northern regions of Japan.

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Genetic Stats

Predicted Adult Weight

76 lbs

Genetic Age
15 human years

Based on the date of birth provided

DNA Breed Origins

Breed colors:
Alaskan Malamute
German Shepherd Dog
Irish Wolfhound
Akita

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Health Summary

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Persia inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Canine Multifocal Retinopathy, cmr1

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Persia inherited one copy of the variant we tested

What does this result mean?

This result should not impact Persia’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

This result should be taken into account as part of your breeding program. Persia will pass this variant to ~50% of her offspring.

What is Canine Multifocal Retinopathy, cmr1?

This is a non-progressive retinal disease that, in rare cases, can lead to vision loss. Dogs with larger lesions can suffer from vision loss. CMR is fairly non-progressive; new lesions will typically stop forming by the time a dog is an adult, and some lesions will even regress with time.

ALT Activity

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Persia inherited one copy of the variant we tested

Why is this important to your vet?

Persia has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Persia has this genotype, as ALT is often used as an indicator of liver health and Persia is likely to have a lower than average resting ALT activity. As such, an increase in Persia’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity (ABCB1)

Identified in German Shepherd Dogs

Factor VII Deficiency (F7 Exon 5)

Identified in Alaskan Malamutes

Hemophilia A (F8 Exon 11, German Shepherd Variant 1)

Identified in German Shepherd Dogs

Hemophilia A (F8 Exon 1, German Shepherd Variant 2)

Identified in German Shepherd Dogs

Canine Leukocyte Adhesion Deficiency Type III, CLAD III (FERMT3, German Shepherd Variant)

Identified in German Shepherd Dogs

Platelet Factor X Receptor Deficiency, Scott Syndrome (TMEM16F)

Identified in German Shepherd Dogs

Day Blindness (CNGA3 Exon 7, German Shepherd Variant)

Identified in German Shepherd Dogs

Urate Kidney & Bladder Stones (SLC2A9)

Identified in German Shepherd Dogs

Primary Ciliary Dyskinesia, PCD (NME5, Alaskan Malamute Variant)

Identified in Alaskan Malamutes

Anhidrotic Ectodermal Dysplasia (EDA Intron 8)

Identified in German Shepherd Dogs

Renal Cystadenocarcinoma and Nodular Dermatofibrosis (FLCN Exon 7)

Identified in German Shepherd Dogs

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 3, German Shepherd Variant)

Identified in German Shepherd Dogs

Degenerative Myelopathy, DM (SOD1A)

Identified in German Shepherd Dogs

Polyneuropathy, AMPN (NDRG1 SNP, Alaskan Malamute Variant)

Identified in Alaskan Malamutes

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

E Locus (MC1R)
Can have a melanistic mask (Eme)
K Locus (CBD103)
More likely to have a mostly solid black or brown coat (KBky)
Intensity Loci LINKAGE
No impact on coat pattern (Dilute Red Pigmentation)
A Locus (ASIP)
Not expressed (awat)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (DD)
Cocoa (HPS3)
No co alleles, not expressed (NN)
B Locus (TYRP1)
Black or gray hair and skin (Bb)
Saddle Tan (RALY)
Not expressed (NN)
S Locus (MITF)
Likely flash, parti, piebald, or extreme white (spsp)
M Locus (PMEL)
No merle alleles (mm)
R Locus (USH2A) LINKAGE
Likely no impact on coat pattern (rr)
H Locus (Harlequin)
No harlequin alleles (hh)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely unfurnished (no mustache, beard, and/or eyebrows) (II)
Coat Length (FGF5)
Likely short or mid-length coat (GT)
Shedding (MC5R)
Likely heavy/seasonal shedding (CT)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Coat Texture (KRT71)
Likely straight coat (CC)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (CC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Unlikely to have hind dew claws (CC)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Larger (NN)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Larger (TT)
Body Size (GHR - E191K)
Larger (GG)
Body Size (GHR - P177L)
Larger (CC)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)
Appetite (POMC) LINKAGE
Normal food motivation (NN)
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Through Persia’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1e

Haplotype

A25

Map

A1e

Vallecito's Jewel of Persia’s Haplogroup

This female lineage likely stems from some of the original Central Asian wolves that were domesticated into modern dogs starting about 15,000 years ago. It seemed to be a fairly rare dog line for most of dog history until the past 300 years, when the lineage seemed to “explode” out and spread quickly. What really separates this group from the pack is its presence in Alaskan village dogs and Samoyeds. It is possible that this was an indigenous lineage brought to the Americas from Siberia when people were first starting to make that trip themselves! We see this lineage pop up in overwhelming numbers of Irish Wolfhounds, and it also occurs frequently in popular large breeds like Bernese Mountain Dogs, Saint Bernards and Great Danes. Shetland Sheepdogs are also common members of this maternal line, and we see it a lot in Boxers, too. Though it may be all mixed up with European dogs thanks to recent breeding events, its origins in the Americas makes it a very exciting lineage for sure!

A25

Vallecito's Jewel of Persia’s Haplotype

Part of the large A1e haplogroup, we have detected this haplotype in village dogs in Mexico. We also see it in Irish Wolfhounds, Great Pyrenees, Brittanys, and Labrador Retrievers.

Some other Embark dogs with this haplotype:

Irish Wolfhounds are a consistent carrier of A1e.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Persia inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Persia is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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