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“Bella”
Tottlefields Bizzy Bee

English Cocker Spaniel (Working Type)

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Place of Birth

Chatteris, England, United Kingdom

Current Location

Witchford, England, United Kingdom

From

Witchford, Ely, UK

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Registration

The Kennel Club (KC): AU01578303

Genetic Breed Result

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English Cocker Spaniel (Working Type)

English Cockers are a medium-size dog with long ears and a happy disposition. The name Cocker comes from their use to hunt woodcock in England, although English Cockers have been used to hunt many other types of birds as well. They make great companion dogs for people who can give them the exercise they need. A field-bred cocker spaniel is first and foremost an upland flushing dog, bred for skills like hup, retrieve to hand, quarter, follow hand signals, and steady.

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Genetic Stats

Predicted Adult Weight

24 lbs

Genetic Age
45 human years

Based on the date of birth provided

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Changes to this dog’s profile
  • On 1/28/2021 changed handle from "bella4196" to "tottlefieldsbizzybee"
  • On 1/28/2021 changed name from "Bella" to "Tottlefields Bizzy Bee"

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Health Summary

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Bella is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Intervertebral Disc Disease (Type I)

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Bella inherited both copies of the variant we tested

How to interpret this result

Bella has two copies of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

ALT Activity

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Bella inherited one copy of the variant we tested

Why is this important to your vet?

Bella has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Bella has this genotype, as ALT is often used as an indicator of liver health and Bella is likely to have a lower than average resting ALT activity. As such, an increase in Bella’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Working-type English Cocker Spaniels

Familial Nephropathy (COL4A4 Exon 3, Cocker Spaniel Variant)

Identified in Working-type English Cocker Spaniels

Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency (PFKM, Whippet and English Springer Spaniel Variant)

Identified in Working-type English Cocker Spaniels

Acral Mutilation Syndrome (GDNF-AS, Spaniel and Pointer Variant)

Identified in Working-type English Cocker Spaniels

Exercise-Induced Collapse, EIC (DNM1)

Identified in Working-type English Cocker Spaniels

Additional Genetic Conditions

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Through Bella’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A426

Map

A1d

Tottlefields Bizzy Bee’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A426

Tottlefields Bizzy Bee’s Haplotype

Part of the A1d haplogroup, this haplotype occurs most frequently in mixed-breed dogs.

Some other Embark dogs with this haplotype:

The vast majority of Rottweilers have the A1d haplogroup.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Bella inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Bella is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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