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“Tiffany”
CH JBK Tiffany & Co CGC TKN BCAT RN

Border Collie

“Tiffany is a show line border collie from Texas currently living in the PNW.”

Instagram tag
@hazelwoodbc

Place of Birth

Fort Worth, TX, USA

Current Location

Pullman, Washington, USA

From

Fort Worth, TX, USA

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Registration

American Kennel Club (AKC): DN579055701

Genetic Breed Result

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Border Collie

Border Collies are highly energetic and work-oriented herding dogs, whose stamina is matched by their intelligence and alertness. While they excel at the herding they were bred for, many Border Collies also enjoy flyball, obedience, and other canine sports. As long as they have a job to do and are physically and mentally stimulated, Border Collies can make excellent companions for the right owners.

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Changes to this dog’s profile
  • On 4/5/2020 changed name from "Tiffany" to "JBK Tiffany & Co"

Health Summary

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Tiffany inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Goniodysgenesis and Glaucoma, Pectinate Ligament Dysplasia, PLD

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Tiffany inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Tiffany’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Tiffany is unlikely to develop this condition due to this variant because she only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Goniodysgenesis and Glaucoma, Pectinate Ligament Dysplasia, PLD?

Goniodysgenesis is an abnormality of the anterior chamber of the eye. The fluid that normally drains out of the eye exits through a drainage angle. With goniodysgenesis, the angle is closed and prevents the fluid of the eye from accessing its exit tract. This can lead to glaucoma, which is when high intraocular pressure occurs from the fluid build up.

ALT Activity

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Tiffany inherited one copy of the variant we tested

Why is this important to your vet?

Tiffany has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Tiffany has this genotype, as ALT is often used as an indicator of liver health and Tiffany is likely to have a lower than average resting ALT activity. As such, an increase in Tiffany’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity (ABCB1)

Identified in Border Collies

Trapped Neutrophil Syndrome, TNS (VPS13B)

Identified in Border Collies

Collie Eye Anomaly (NHEJ1)

Identified in Border Collies

Primary Lens Luxation (ADAMTS17)

Identified in Border Collies

Neuronal Ceroid Lipofuscinosis 5, NCL 5 (CLN5 Exon 4 SNP, Border Collie Variant)

Identified in Border Collies

Myotonia Congenita (CLCN1 Exon 23, Australian Cattle Dog Variant)

Identified in Border Collies

Cobalamin Malabsorption (CUBN Exon 53, Border Collie Variant)

Identified in Border Collies

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Tiffany’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A249

Map

A1d

JBK Tiffany & Co’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A249

JBK Tiffany & Co’s Haplotype

Part of the large A1d haplogroup, this haplotype occurs most commonly in Border Collies. It’s a rare find!

The vast majority of Rottweilers have the A1d haplogroup.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Tiffany inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Tiffany is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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