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“Thresher”
GCHS Glade Mill Dark Tide

Beagle

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Place of Birth

United States

Current Location

United States

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Registration

AKC: HP 52684401

Genetic Breed Result

Beagle

Beagle

The Beagle is a scent hound and a great family pet. They are known for being affectionate and having loud voices.

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Genetic Stats

Predicted Adult Weight

31 lbs

Genetic Age
41 human years

Based on the date of birth provided

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Changes to this dog’s profile
  • On 3/16/2019 changed name from "Thresher" to "Glade Mill Dark Tide"

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Health Summary

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Thresher is at increased risk for two genetic health conditions.

And inherited one variant that you should learn more about.

Factor VII Deficiency

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Thresher inherited both copies of the variant we tested

How to interpret this result

Thresher has two copies of a variant in the F7 gene and is at risk for being Factor VII deficient. This variant was first observed in research colonies of Beagles in North America and Europe but has also been observed in the pet population. You may notice that Thresher has mild to moderate bleeding tendencies, or he or she might appear completely normal. However, your veterinarian must be informed that Thresher has Factor VII deficiency as affected dogs are at risk for post-surgical hemorrhage.

What is Factor VII Deficiency?

Factor VII deficiency is a type of coagulopathy, a disorder of blood clotting. It is characterized by mild to moderate abnormal bleeding (generally less severe than that caused by deficiencies in other clotting factors such as as Factors VIII or IX). Some dogs with this condition will show no clinical signs.

Intervertebral Disc Disease (Type I)

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Thresher inherited both copies of the variant we tested

How to interpret this result

Thresher has two copies of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

ALT Activity

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Thresher inherited one copy of the variant we tested

Why is this important to your vet?

Thresher has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Thresher has this genotype, as ALT is often used as an indicator of liver health and Thresher is likely to have a lower than average resting ALT activity. As such, an increase in Thresher’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Pyruvate Kinase Deficiency (PKLR Exon 7, Beagle Variant)

Identified in Beagles

Progressive Retinal Atrophy, crd4/cord1 (RPGRIP1)

Identified in Beagles

Neonatal Cerebellar Cortical Degeneration (SPTBN2, Beagle Variant)

Identified in Beagles

Hypocatalasia, Acatalasemia (CAT)

Identified in Beagles

Cobalamin Malabsorption (CUBN Exon 8, Beagle Variant)

Identified in Beagles

Musladin-Lueke Syndrome, MLS (ADAMTSL2)

Identified in Beagles

Osteogenesis Imperfecta (COL1A2, Beagle Variant)

Identified in Beagles

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

E Locus (MC1R)
No dark mask or grizzle (Ee)
K Locus (CBD103)
More likely to have a patterned haircoat (kyky)
Intensity Loci LINKAGE
Any light hair likely yellow or tan (Intermediate Red Pigmentation)
A Locus (ASIP)
Black/Brown and tan coat color pattern (atat)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (Dd)
B Locus (TYRP1)
Black or gray hair and skin (BB)
Saddle Tan (RALY)
Likely saddle tan patterned (NN)
S Locus (MITF)
Likely flash, parti, piebald, or extreme white (spsp)
M Locus (PMEL)
No merle alleles (mm)
H Locus (Harlequin)
No harlequin alleles (hh)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely unfurnished (no mustache, beard, and/or eyebrows) (II)
Coat Length (FGF5)
Likely short or mid-length coat (GG)
Shedding (MC5R)
Likely heavy/seasonal shedding (CC)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Coat Texture (KRT71)
Likely straight coat (CC)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (CC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Unlikely to have hind dew claws (CC)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Smaller (II)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Larger (TT)
Body Size (GHR - E191K)
Intermediate (GA)
Body Size (GHR - P177L)
Larger (CC)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)
Appetite (POMC) LINKAGE
Normal food motivation (NN)
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Through Thresher’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A414/643

Map

A1b

Glade Mill Dark Tide’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A414/643

Glade Mill Dark Tide’s Haplotype

Part of the A1b haplogroup, this haplotype occurs most frequently in the English Springer Spaniels.

Some other Embark dogs with this haplotype:

A1b is the most common haplogroup found in German Shepherds.

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Through Thresher’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.5

Map

A1a

Glade Mill Dark Tide’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.5

Glade Mill Dark Tide’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs most commonly in Beagles.

Some other Embark dogs with this haplotype:

Dogs with A1a lineage travelled during European Colonial times.

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