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The Duke

Armenian Gampr

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“His best friend is a duck.”

Place of Birth

Mayisyan, Armenia

Current Location

Ailsa Craig, ON, Canada

From

Mayisyan, Armenia

This dog has been viewed and been given 8 wags

Registration

N/A :

Genetic Breed Result

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Armenian Gampr

The Armenian Gampr is an ancient, working livestock guardian dog originally bred in the southern Caucasus Mountains. The Gampr is considered a landrace rather than a breed with a closed population; they are genetically diverse with an emphasis on function rather than form. There are several regional variants of the Gampr.

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Genetic Stats

Predicted Adult Weight

113 lbs

Genetic Age
32 human years

Based on the date of birth provided

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Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain The Duke’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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The Duke inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

GM2 Gangliosidosis

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The Duke inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), The Duke is unlikely to develop this condition due to the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is GM2 Gangliosidosis?

A lysosome is a structure within the cell that digests and removes waste. When the lysosome cannot recycle waste properly, the waste accumulates and causes the cell to die. This form of lysosomal storage disease (gangliosidosis) is caused by buildup of a fatty substance known as ganglioside, especially in cells of the nervous system.

ALT Activity

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The Duke inherited both copies of the variant we tested

Why is this important to your vet?

The Duke has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in The Duke's ALT activity above their current, healthy, ALT activity. As an increase above The Duke’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

E Locus (MC1R)
Can have a melanistic mask (EmE)
K Locus (CBD103)
More likely to have a patterned haircoat (kyky)
Intensity Loci LINKAGE
Any light hair likely yellow or tan (Intermediate Red Pigmentation)
A Locus (ASIP)
Agouti (Wolf Sable) coat color pattern (awat)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (DD)
B Locus (TYRP1)
Black or gray hair and skin (BB)
Saddle Tan (RALY)
Not expressed (II)
S Locus (MITF)
Likely to have little to no white in coat (SS)
M Locus (PMEL)
No merle alleles (mm)
H Locus (Harlequin)
No harlequin alleles (hh)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely unfurnished (no mustache, beard, and/or eyebrows) (II)
Coat Length (FGF5)
Likely short or mid-length coat (GG)
Shedding (MC5R)
Likely light to moderate shedding (TT)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Coat Texture (KRT71)
Likely straight coat (CC)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (CC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Unlikely to have hind dew claws (CC)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Larger (NN)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Larger (TT)
Body Size (GHR - E191K)
Larger (GG)
Body Size (GHR - P177L)
Larger (CC)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)
Appetite (POMC) LINKAGE
Normal food motivation (NN)
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Through The Duke’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1e

Haplotype

A25

Map

A1e

The Duke’s Haplogroup

This female lineage likely stems from some of the original Central Asian wolves that were domesticated into modern dogs starting about 15,000 years ago. It seemed to be a fairly rare dog line for most of dog history until the past 300 years, when the lineage seemed to “explode” out and spread quickly. What really separates this group from the pack is its presence in Alaskan village dogs and Samoyeds. It is possible that this was an indigenous lineage brought to the Americas from Siberia when people were first starting to make that trip themselves! We see this lineage pop up in overwhelming numbers of Irish Wolfhounds, and it also occurs frequently in popular large breeds like Bernese Mountain Dogs, Saint Bernards and Great Danes. Shetland Sheepdogs are also common members of this maternal line, and we see it a lot in Boxers, too. Though it may be all mixed up with European dogs thanks to recent breeding events, its origins in the Americas makes it a very exciting lineage for sure!

A25

The Duke’s Haplotype

Part of the large A1e haplogroup, we have detected this haplotype in village dogs in Mexico. We also see it in Irish Wolfhounds, Great Pyrenees, Brittanys, and Labrador Retrievers.

Some other Embark dogs with this haplotype:

Irish Wolfhounds are a consistent carrier of A1e.

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Through The Duke’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

B

Haplotype

H15.16

Map

B

The Duke’s Haplogroup

B is a relatively rare paternal line that has only recently started to expand. The dominant lineage among the ancient Shih Tzu breed, it is also found among Tibetan Spaniels. Outside of these two breeds, B seems to be a particularly common paternal line among the village dogs of India and Southeast Asia, though it is found as far afield as Africa and down into Oceania. Considering that it is particularly diverse in northern India, it could be that this lineage hung out mostly in South Asia after the expansion of domestic dogs from Central Asia. Because it is present in Mongolia as well, it may not be surprising that ancient East Asian dog breeds are also part of this lineage. Alternatively, perhaps males representing this lineage headed north out of southern Eurasia, which eventually gave rise to the Shih Tzu and may have inspired stylistic representations of lions in ancient China!

H15.16

The Duke’s Haplotype

Part of the B haplogroup, this haplotype occurs most frequently in the Armenian Gampr.

Some other Embark dogs with this haplotype:

The B Haplogroup is most commonly found the adorable Shih Tzu breed.

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