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MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1

Carolina Dog

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“Carolina Dog from Hoosier Hills”

Current Location

Maryland, USA

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Registration

United Kennel Club (UKC):

Genetic Breed Result

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Carolina Dog

The Carolina Dog was originally a landrace, rediscovered as a wild dog by Dr. I. Lehr Brisbin, and originally documented in American dog breed publications in the 1920s. Although descended from free-ranging dogs, Carolina Dogs can make good family pets with proper socialization. Carolina Dogs have been a UKC-recognized breed since 1996 and are now part of the AKC Foundation Stock Service (FSS). While debates rage on about the genetic origins of the breed and whether there are still pockets of feral Carolina dogs living in Southeastern US, AKC and UKC Carolina Dogs clearly have a unique and identifiable genetic signature.

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Changes to this dog’s profile
  • On 8/10/2022 changed name from "MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC" to "MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1"
  • On 8/10/2022 changed name from "MBISS BIS RBIS Hoosier Hills Heavenly Sentinel CT" to "MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC"
  • On 7/18/2022 changed name from "MBISS BIS RBIS Hoosier Hills Heavenly Sentinel" to "MBISS BIS RBIS Hoosier Hills Heavenly Sentinel CT"
  • On 11/26/2021 changed name from "BISS RBIS Hoosier Hill's Heavenly Sentinel "Tengu"" to "MBISS BIS RBIS Hoosier Hills Heavenly Sentinel"
  • On 10/28/2021 changed name from "Hoosier Hill's Heavenly Sentinel "Tengu"" to "BISS RBIS Hoosier Hill's Heavenly Sentinel "Tengu""
  • On 11/23/2020 changed name from "Tengu" to "Hoosier Hill's Heavenly Sentinel "Tengu""

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Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1 inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Exercise-Induced Collapse, EIC

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MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1 inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1 is unlikely to develop this condition due to the variant. This result may be important if you decide to breed this dog - we recommend genetic testing potential mates for this condition.

What is Exercise-Induced Collapse, EIC?

EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.

ALT Activity

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MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1 inherited both copies of the variant we tested

Why is this important to your vet?

MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1 has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1's ALT activity above their current, healthy, ALT activity. As an increase above MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Additional Genetic Conditions

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Base Coat Color

Base Coat Color

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Coat Color Modifiers

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Other Body Features

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Body Size

Performance

Performance

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Through MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

C2

Haplotype

C42/54/55

Map

C2

MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1’s Haplogroup

C2 is a very old female lineage found more commonly among English Setters, English Bulldogs, and American Eskimo Dogs. We also see C2 in village dogs in South Asia. Rather than having a few characteristic breeds representing this lineage particularly well, it is present in a few uncommon individuals of many different breeds. Unlike some European breed lineages that have seen skyrocketing popularity along the path to the modern dogs we see today, C2 tends to reflect the deep history of man's best friend.

C42/54/55

MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1’s Haplotype

Part of the C2 haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

You can often find his haplogroup in the lovable English Bulldog.

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Through MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.48

Map

A1a

MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.48

MBISS BIS RBIS CT GrCH Hoosier Hills Heavenly Sentinel CGC Total Dogx1’s Haplotype

Part of the A1a haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

Dogs with A1a lineage travelled during European Colonial times.

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