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“BLUE”
Sylvaen Sirius

Mixed Ancestry

“He is a first generation ITR-registered Tamaskan Dog!”

Place of Birth

Drenje Brdovečko, Zagrebačka županija, Croatia

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Registration

International Tamaskan Register (ITR):
Microchip: 191100002295636

Genetic Breed Result

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Czechoslovakian Vlcak

Czechoslovakian Vlcaks are a relatively new breed of dog that hail from Czechoslovakia. Nearly indistinguishable from a wolf to an untrained eye, these large and handsome dogs are the result of a crossbreeding between a German Shepherd and a Carpathian wolf in the 1950’s.

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Siberian Husky

Bred initially in Northern Siberia, the Siberian Husky is a medium-sized working dog who is quick and light on their feet. Their moderately compact and well furred body, erect ears and brush tail suggest their Northern heritage. Huskies are very active and energetic and are known for being long distance sled dogs.

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Belgian Sheepdog

The Belgian Sheepdog is one of the four varieties of Belgian Shepherd, though the AKC distinguishes them as their own breed. This active working dog is renowned for its intelligence and drive. If given the opportunity for plenty of physical and mental exercise, the Belgian Sheepdog will astound you with its athleticism and versatility.

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Belgian Tervuren

The Belgian Tervuren is one of the four varieties of Belgian Shepherd, though the AKC distinguishes them as their own breed. This active working dog is renowned for its intelligence and drive. If given the opportunity for plenty of physical and mental exercise, the Belgian Tervuren will astound you with its athleticism and versatility.

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DNA Breed Origins

Breed colors:
Czechoslovakian Vlcak
Siberian Husky
Belgian Sheepdog
Belgian Tervuren

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Changes to this dog’s profile
  • On 5/2/2024 changed handle from "sylvaensirius" to "sylvaen_sirius"

Health Summary

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BLUE inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Copper Toxicosis (Accumulating)

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BLUE inherited one copy of the variant we tested

What does this result mean?

We do not know whether this increases the risk that BLUE will develop Copper Toxicosis (Accumulating).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. Not enough dogs with BLUE's breed have been studied to know whether or not this variant will increase BLUE's risk of developing this disease.

Impact on Breeding

Research into the clinical impact of this variant is ongoing. We recommend tracking this genetic result and incidence of Copper Toxicosis (Accumulating) in your breeding program and related dogs.

What is Copper Toxicosis (Accumulating)?

Copper toxicosis is a condition in which affected dogs have difficulty excreting excess copper from their liver. The liver accumulates more copper until it eventually begins failing. Multiple genetic and environmental factors contribute to the development of this condition.

ALT Activity

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BLUE inherited one copy of the variant we tested

Why is this important to your vet?

BLUE has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that BLUE has this genotype, as ALT is often used as an indicator of liver health and BLUE is likely to have a lower than average resting ALT activity. As such, an increase in BLUE’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity (ABCB1)

Identified in Czechoslovakian Vlcaks

Hemophilia A (F8 Exon 11, German Shepherd Variant 1)

Identified in Czechoslovakian Vlcaks

Hemophilia A (F8 Exon 1, German Shepherd Variant 2)

Identified in Czechoslovakian Vlcaks

Canine Leukocyte Adhesion Deficiency Type III, CLAD III (FERMT3, German Shepherd Variant)

Identified in Czechoslovakian Vlcaks

Platelet Factor X Receptor Deficiency, Scott Syndrome (TMEM16F)

Identified in Czechoslovakian Vlcaks

X-Linked Progressive Retinal Atrophy 1, XL-PRA1 (RPGR)

Identified in Siberian Huskies

Day Blindness (CNGB3 Deletion, Alaskan Malamute Variant)

Identified in Siberian Huskies

Day Blindness (CNGA3 Exon 7, German Shepherd Variant)

Identified in Czechoslovakian Vlcaks

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Czechoslovakian Vlcaks

Anhidrotic Ectodermal Dysplasia (EDA Intron 8)

Identified in Czechoslovakian Vlcaks

Renal Cystadenocarcinoma and Nodular Dermatofibrosis (FLCN Exon 7)

Identified in Czechoslovakian Vlcaks

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 3, German Shepherd Variant)

Identified in Belgian Sheepdogs, Belgian Tervurens, and more

GM1 Gangliosidosis (GLB1 Exon 15, Alaskan Husky Variant)

Identified in Siberian Huskies

Degenerative Myelopathy, DM (SOD1A)

Identified in Czechoslovakian Vlcaks and Siberian Huskies

Spongy Degeneration with Cerebellar Ataxia 1 (KCNJ10)

Identified in Belgian Sheepdogs and Belgian Tervurens

Spongy Degeneration with Cerebellar Ataxia 2 (ATP1B2)

Identified in Belgian Sheepdogs and Belgian Tervurens

Cardiomyopathy and Juvenile Mortality (YARS2)

Identified in Belgian Sheepdogs and Belgian Tervurens

Hereditary Cerebellar Ataxia (SELENOP, Belgian Shepherd Variant)

Identified in Belgian Sheepdogs and Belgian Tervurens

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through BLUE’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A388

Map

A1a

Sylvaen Sirius’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A388

Sylvaen Sirius’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs most frequently in Staffordshire Terriers, Labrador Retrievers, and English Bulldogs.

Shar Pei dogs think A1a is the coolest!

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Through BLUE’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

F

Haplotype

H9.4

Map

F

Sylvaen Sirius’s Haplogroup

F is the odd duck in the family of domestic dog male lineages. This paternal lineage is genetically closer to wolves, foxes, and jackals than to other dogs. This indicates that it came into the dog population after dogs were originally domesticated, when one particularly attractive male wolf mated with a female dog, over 6,000 years ago. Since then, these dogs found their way into Africa and Mongolia. It hasn't been found outside those areas except in Basenjis. Basenjis are an iconic African breed, that first made its way to the USA in the early 20th century when a handful of individuals were imported from the Congo. The Basenji is an ancient breed which is distantly related to other dog breeds (most of which are European or Asian), and it has the earliest separation date from all other breed populations. Unsurprisingly, the F lineage has also been found in African village dogs, as well as, surprisingly, some samples from Mongolia. The fact the lineage is found in two very distant places is evidence that it entered the dog population many thousands of years ago.

H9.4

Sylvaen Sirius’s Haplotype

A member of the F haplogroup, this haplotype is found most frequently in mixed breed dogs with some wolf ancestry.

Congo Dogs in Africa commonly have this hapgloroup.

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