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Swiftrun Sitka Centennial Rain

Chinook

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This dog has been viewed and been given 5 wags

Registration

United Kennel Club (UKC): A948,125

Genetic Breed Result

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Chinook

Created in the White Mountains of New Hampshire, the Chinook dog breed made his name on Admiral Byrd’s first Antarctic expedition in 1928. These days he’s a multipurpose dog who’s happy hiking, competing in agility and other dog sports, pulling a sled or other conveyance, and playing with the kids.

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Here’s what Swiftrun Sitka Centennial Rain’s family tree may have looked like.
While there may be other possible configurations of her family’s relationships, this is the most likely family tree to explain Swiftrun Sitka Centennial Rain’s breed mix.
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Health Summary

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Swiftrun Sitka Centennial Rain is at increased risk for two genetic health conditions.

And inherited one variant that you should learn more about.

Multiple Drug Sensitivity

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Swiftrun Sitka Centennial Rain inherited one copy of the variant we tested

How to interpret this result

Swiftrun Sitka Centennial Rain has one copy of a variant at the ABCB1 gene and is at risk for displaying adverse drug reactions. While she may not be as severely affected as a dog with two copies of the ABCB1 drug sensitivity allele, normal dosages of drugs could still have potentially severe effects on Swiftrun Sitka Centennial Rain. Please inform your veterinarian that Swiftrun Sitka Centennial Rain carries this variant; it is essential that they know this information before prescribing drugs.

What is Multiple Drug Sensitivity?

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with a mutation in the ABCB1 gene.

Intervertebral Disc Disease (Type I)

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Swiftrun Sitka Centennial Rain inherited one copy of the variant we tested

What does this result mean?

Our research indicates that this genetic variant is likely to increase the risk that Swiftrun Sitka Centennial Rain will develop this disease.

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Swiftrun Sitka Centennial Rain have not yet been the focus of research studies, our data indicates that Swiftrun Sitka Centennial Rain is likely to be at increased risk.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

ALT Activity

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Swiftrun Sitka Centennial Rain inherited both copies of the variant we tested

Why is this important to your vet?

Swiftrun Sitka Centennial Rain has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Swiftrun Sitka Centennial Rain's ALT activity above their current, healthy, ALT activity. As an increase above Swiftrun Sitka Centennial Rain’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Chondrodystrophy

Identified in Chinooks

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

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Through Swiftrun Sitka Centennial Rain’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A18/19/20/21/27/36/94/109

Map

A1b

Swiftrun Sitka Centennial Rain’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A18/19/20/21/27/36/94/109

Swiftrun Sitka Centennial Rain’s Haplotype

Part of the large A1b haplogroup, we see this haplotype in village dogs in over 25 countries across the world. We have detected this haplotype in lots of breeds, and it occurs most commonly in German Shepherd Dogs, Maltese, English Springer Spaniels, and English Setters.

A1b is the most common haplogroup found in German Shepherds.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Swiftrun Sitka Centennial Rain inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Swiftrun Sitka Centennial Rain is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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