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“Ostara”
Swampy Creek Here Comes the Sun

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“Ostara is a bouncy and sweet dog, her favorite thing to do is jump and take big leaps; she also loves to play in water.”

Place of Birth

Allegan, MI, USA

Current Location

Clarkston, MI, USA

From

Allegan, MI, USA

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Registration

AKC: DN57119001

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Genetic Stats

Predicted Adult Weight

35 lbs

Genetic Age
28 human years

Based on the date of birth provided

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Health Summary

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Ostara is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Multiple Drug Sensitivity

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Ostara inherited one copy of the variant we tested

How to interpret this result

Ostara has one copy of a variant at the ABCB1 gene and is at risk for displaying adverse drug reactions. While she may not be as severely affected as a dog with two copies of the ABCB1 drug sensitivity allele, normal dosages of drugs could still have potentially severe effects on Ostara. Please inform your veterinarian that Ostara carries this variant; it is essential that they know this information before prescribing drugs.

What is Multiple Drug Sensitivity?

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with a mutation in the ABCB1 gene.

ALT Activity

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Ostara inherited one copy of the variant we tested

Why is this important to your vet?

Ostara has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Ostara has this genotype, as ALT is often used as an indicator of liver health and Ostara is likely to have a lower than average resting ALT activity. As such, an increase in Ostara’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Australian Shepherds, Australian Shepherds, and more

Collie Eye Anomaly (NHEJ1)

Identified in Australian Shepherds, Australian Shepherds, and more

Canine Multifocal Retinopathy, cmr1 (BEST1 Exon 2)

Identified in Australian Shepherds, Australian Shepherds, and more

Hereditary Cataracts (HSF4 Exon 9, Australian Shepherd Variant)

Identified in Australian Shepherds, Australian Shepherds, and more

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Australian Shepherds, Australian Shepherds, and more

Neuronal Ceroid Lipofuscinosis 6, NCL 6 (CLN6 Exon 7, Australian Shepherd Variant)

Identified in Australian Shepherds, Australian Shepherds, and more

Neuronal Ceroid Lipofuscinosis 8, NCL 8 (CLN8, Australian Shepherd Variant)

Identified in Australian Shepherds, Australian Shepherds, and more

Craniomandibular Osteopathy, CMO (SLC37A2)

Identified in Australian Shepherds, Australian Shepherds, and more

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

E Locus (MC1R)
No dark mask or grizzle (EE)
K Locus (CBD103)
More likely to have a patterned haircoat (kyky)
Intensity Loci LINKAGE
Any light hair likely yellow or tan (Intermediate Red Pigmentation)
A Locus (ASIP)
Black/Brown and tan coat color pattern (ata)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (DD)
B Locus (TYRP1)
Black or gray hair and skin (Bb)
Saddle Tan (RALY)
Not saddle tan patterned (II)
S Locus (MITF)
Likely to have little to no white in coat (SS)
M Locus (PMEL)
One merle allele, likely to appear merle or "phantom merle" (M*m)
H Locus (Harlequin)
No harlequin alleles (hh)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely unfurnished (no mustache, beard, and/or eyebrows) (II)
Coat Length (FGF5)
Likely long coat (TT)
Shedding (MC5R)
Likely heavy/seasonal shedding (CC)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Coat Texture (KRT71)
Likely straight coat (CC)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (CC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Unlikely to have hind dew claws (CC)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Smaller (II)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Smaller (AA)
Body Size (GHR - E191K)
Intermediate (GA)
Body Size (GHR - P177L)
Larger (CC)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)
Appetite (POMC) LINKAGE
Normal food motivation (NN)
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