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“Rage”
Sprenkels Tears Of Rage

American Bulldog

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Genetic Breed Result

Sprenkels Tears Of Rage

“Rage”
Sprenkels Tears Of Rage

American Bulldog
100.0% American Bulldog

American Bulldog

American bulldogs are enjoying a healthy increase in popularity, either as a working/protector dog or as a family pet. All over the world, they are used variously as "hog dogs" (catching escaped pigs or hunting razorbacks), as cattle drovers and as working or sport K-9s. American Bulldogs also successfully compete in several dog sports such as dog obedience, Iron Dog competition and weight pulling.

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Genetic Stats

Predicted Adult Weight

78 lbs

Genetic Age
41 human years

Based on the date of birth provided

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Health Summary

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Rage inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Urate Kidney & Bladder Stones

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Rage inherited one copy of the variant we tested

What does this result mean?

This result should not impact Rage’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring.

What is Urate Kidney & Bladder Stones?

This condition causes kidney and bladder stones composed of urate. In most dogs, uric acid is converted to allantoin, an inert substance that is then excreted in the urine. Dogs with HUU have defects in the pathway that converts uric acid to allantoin. As such, uric acid builds up, crystallizes and forms urate stones in the kidney and bladder. Uric acid is an intermediate of purine metabolism. While hyperuricemia in other species (including humans) can lead to painful conditions such as gout, dogs do not develop systemic signs of hyperuricemia.

ALT Activity

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Rage inherited one copy of the variant we tested

Why is this important to your vet?

Rage has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Rage has this genotype, as ALT is often used as an indicator of liver health and Rage is likely to have a lower than average resting ALT activity. As such, an increase in Rage’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Canine Multifocal Retinopathy, cmr1 (BEST1 Exon 2)

Identified in American Bulldogs

Neuronal Ceroid Lipofuscinosis 10, NCL 10 (CTSD Exon 5, American Bulldog Variant)

Identified in American Bulldogs

Ichthyosis (NIPAL4, American Bulldog Variant)

Identified in American Bulldogs

Additional Genetic Conditions

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Coat Color

Coat Color

E Locus (MC1R)
Can have a melanistic mask (EmE)
K Locus (CBD103)
More likely to have a mostly solid black or brown coat (KBky)
Intensity Loci LINKAGE
No impact on coat pattern (Intermediate Red Pigmentation)
A Locus (ASIP)
Not expressed (ayay)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (DD)
B Locus (TYRP1)
Black or gray hair and skin (BB)
Saddle Tan (RALY)
Not expressed (NN)
S Locus (MITF)
Likely flash, parti, piebald, or extreme white (spsp)
M Locus (PMEL)
No merle alleles (mm)
H Locus (Harlequin)
No harlequin alleles (hh)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely unfurnished (no mustache, beard, and/or eyebrows) (II)
Coat Length (FGF5)
Likely short or mid-length coat (GG)
Shedding (MC5R)
Likely light to moderate shedding (TT)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Coat Texture (KRT71)
Likely straight coat (CC)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (CC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Unlikely to have hind dew claws (CC)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Larger (NN)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Larger (TT)
Body Size (GHR - E191K)
Larger (GG)
Body Size (GHR - P177L)
Larger (CC)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)
Appetite (POMC) LINKAGE
Normal food motivation (NN)
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Through Rage’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A247

Map

A1d

Sprenkels Tears Of Rage’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A247

Sprenkels Tears Of Rage’s Haplotype

Part of the large A1d haplogroup, this common haplotype occurs in village dogs all over the world. Among the 32 breeds we have sampled it in, the most common occurrences include Boxers, Labrador Retrievers, and Papillons.

Some other Embark dogs with this haplotype:

The vast majority of Rottweilers have the A1d haplogroup.

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Through Rage’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.7

Map

A1a

Sprenkels Tears Of Rage’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.7

Sprenkels Tears Of Rage’s Haplotype

Part of the large A1a haplogroup, this haplotype is found in village dogs throughout the world (including Asia, which is uncommon for A1a’s). We also see it in 10 of our breeds, including most frequently in English Springer Spaniel, Maltese, Havanese, and Rottweiler.

Some other Embark dogs with this haplotype:

Dogs with A1a lineage travelled during European Colonial times.

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