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Sophie

Mixed Breed

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This dog has been viewed 248 times and been given 4 wags

Genetic Breed Result

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Mixed Breed

23.6% Rat Terrier
18.0% Siberian Husky
13.3% German Shorthaired Pointer
12.7% American Staffordshire Terrier
10.4% German Shepherd Dog
8.3% Collie
7.1% Chow Chow
6.6% Supermutt

Embark Supermutt analysis

What’s in that Supermutt? There may be small amounts of DNA from these distant ancestors:

Rat Terrier Rat Terrier
The Rat Terrier is an American dog breed with a background as a farm dog and hunting companion.
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Siberian Husky Siberian Husky
Bred initially in Northern Siberia, the Siberian Husky is a medium-sized working dog who is quick and light on their feet. Their moderately compact and well furred body, erect ears and brush tail suggest their Northern heritage. Huskies are very active and energetic and are known for being long distance sled dogs.
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German Shorthaired Pointer German Shorthaired Pointer
German Shorthaired Pointers are highly intelligent and energetic hunting dogs, while being a very friendly and willing companion.
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American Staffordshire Terrier American Staffordshire Terrier
American Staffordshire Terrier's are powerul but playful dogs, that are both loyal and affectionate with their owners.
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German Shepherd Dog German Shepherd Dog
German Shepherds are confident, courageous dogs with a keen sense of smell and notable intelligence.
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Collie Collie
Collies are attractive herding dogs, boasting a beautiful coat while being highly intelligent. They also make for extremely loyal and sweet family pets.
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Chow Chow Chow Chow
This distinctive-looking dog breed has a proud, independent spirit that some describe as catlike. Often aloof and suspicious of strangers, the Chow Chow may not be a cuddle buddy, but for the right person, they are a fiercly loyal companion.
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Genetic Stats

Wolfiness: 1.2 % MEDIUM Learn More
Predicted Adult Weight: 37 lbs Learn More
Genetic Age: 76 human years Learn More

Breed Mix Matches

Explore other Embark dogs who have breed mixes that are similar to Sophie’s.
A Mix Match of 100 means they are the exact same breed mix!

DNA Breed Origins

What’s this?
Breed colors:
Rat Terrier
Siberian Husky
German Shorthaired Pointer
American Staffordshire Terrier
German Shepherd Dog
Collie
Chow Chow
Supermutt

Explore:

Family tree

Health

Traits

Maternal Haplotype

Paternal Haplotype

Would you like more information? Have you found a lost dog wearing an Embark dog tag? You can contact us at:

 
Family Tree From Embark PARENTS GRANDPARENTS GREAT GRANDPARENTS Rat Terrier mix Mixed Rat Terrier American Staffordshire Terrier / Chow Chow mix Siberian Husky / Collie mix German Shorthaired Pointer / German Shepherd Dog mix Rat Terrier Rat Terrier American Staffordshire Terrier Chow Chow mix Siberian Husky Collie mix German Shorthaired Pointer German Shepherd Dog
Explore by tapping the parents and grandparents.

Our algorithms predict this is the most likely family tree to explain Sophie’s breed mix, but this family tree may not be the only possible one.

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Health

Traits

Maternal Haplotype

Paternal Haplotype

Summary

0
AT RISK
1
CARRIER
166
CLEAR
Tap above or scroll down to see more

Clinical traits

These genetic traits are valuable to your veterinarian and can inform the clinical decisions and diagnoses they make.

Alanine Aminotransferase Activity result: Low Normal
This result helps your vet understand what your dog's baseline ALT activity is. The enzyme alanine aminotransferase, or ALT, is commonly used to evaluate liver health. Do…
Sophie has one copy of a mutation associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Sophie has t…

Not At Risk

Good news! Sophie did not test positive for any of the genetic diseases that Embark screens for. Read on to learn more about the conditions we test for, but rest assured that Sophie does not have the mutations known to cause them.

It is still important to let your veterinarian know these results because they could help guide Sophie’s diagnosis and treatment if she gets sick in the future. Many other diseases caused by environmental factors or undiscovered genetic variants can cause symptoms similar to diseases we test for. By ruling out these mutations, your veterinarian will be able to find the true cause more quickly. Your veterinarian will also know they can safely prescribe medications some dogs are sensitive to.

Carrier for 1 genetic condition

Sophie is a carrier for 1 of the genetic diseases that Embark tests for.
What does Carrier mean?

Sophie has inherited a recessive allele for a genetic trait or mutation. This is not enough to cause symptoms of the disease, but is important to bear in mind if Sophie ever has children.

Condition List

Degenerative Myelopathy
(SOD1A)
Brain and Spinal Cord

A disease of mature dogs, this is a progressive degenerative disorder of the spinal cord that can cause muscle wasting and gait abnormalities. Affected dogs do not usuall…

Common Conditions

Good news! Sophie tested clear for 20 genetic conditions that are common in her breed mix.
Condition List

MDR1 Drug Sensitivity
(MDR1)
Clinical

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with mutatio…

Seen in German Shepherd Dogs, Collies, but not Sophie.

Factor VIII Deficiency, Hemophilia A
(F8 Exon 11, Shepherd Variant 1)
Blood

Coagulopathies, disorders of blood clotting, can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies are often at risk for excessive bleeding dur…

Seen in German Shepherd Dogs, but not Sophie.

Factor VIII Deficiency, Hemophilia A
(F8 Exon 1, Shepherd Variant 2)
Blood

Coagulopathies, disorders of blood clotting, can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies are often at risk for excessive bleeding dur…

Seen in German Shepherd Dogs, but not Sophie.

Von Willebrand Disease Type II
(VWF Exon 28)
Blood

Coagulopathies, disorders of blood clotting, can lead to symptoms such as easy bruising or bleeding. Dogs with coagulopathies are often at risk for excessive bleeding dur…

Seen in German Shorthaired Pointers, but not Sophie.

Canine Leukocyte Adhesion Deficiency Type III (LAD3)
(FERMT3)
Blood

A rare disorder of white blood cells, this causes increased susceptibility to infections and bleeding tendencies. Affected dogs present with a history of persistent skin …

Seen in German Shepherd Dogs, but not Sophie.

Canine Elliptocytosis
(SPTB Exon 30)
Blood

A benign disease that affects red blood cell shape, elliptocytosis rarely causes symptoms. Upon examination of a blood smear, however, affected dogs have elongated, oval …

Seen in Chow Chows, but not Sophie.

Cyclic Neutropenia, Gray Collie Syndrome
(AP3B1 Exon 20)
Blood

This is a disease of neutrophil, a type of white blood cell, production, where the number of circulating neutrophils drops precipitously, leaving dogs prone to bacterial …

Seen in Collies, but not Sophie.

Progressive Retinal Atrophy - crd1
(PDE6B)
Eyes

This retinal disease causes progressive, nonpainful vision loss. The retina contains the cells, photoreceptors, that collect information about light: that is, they are th…

Seen in American Staffordshire Terriers, but not Sophie.

Progressive Retinal Atrophy - crd2
(IQCB1)
Eyes

This retinal disease causes progressive, nonpainful vision loss. The retina contains the cells, photoreceptors, that collect information about light: that is, they are th…

Seen in American Staffordshire Terriers, but not Sophie.

Collie Eye Anomaly, Choroidal Hypoplasia
(NHEJ1)
Eyes

Named for its high prevalence in Collie dogs, Collie Eye Anomaly (CEA) is more correctly termed choroidal hypoplasia and is a developmental disease of the choroid. The ch…

Seen in Collies, but not Sophie.

Achromatopsia
(CNGA3 Exon 7 German Shepherd Variant)
Eyes

This is a progressive, nonpainful disorder of the retina that affects color vision and light perception. Cone cells not only register color, they allow the dog to adjust …

Seen in German Shepherd Dogs, but not Sophie.

Primary Lens Luxation
(ADAMTS17)
Eyes

This surgically correctable condition causes the lens to spontaneously detach from its normal residence within the pupil, leading to reduced visual acuity and irritation …

Seen in Rat Terriers, but not Sophie.

Hyperuricosuria and Hyperuricemia or Urolithiasis
(SLC2A9)
Kidney and Bladder

This condition causes kidney and bladder stones composed of urate; if caught early, it is responsive to dietary management. Uric acid is an intermediate of purine metabol…

Seen in American Staffordshire Terriers, but not Sophie.

X-linked Ectodermal Dysplasia, Anhidrotic Ectodermal Dysplasia
(EDA Intron 8)
Multisystem

This developmental condition can cause a scanty haircoat, malformed teeth, and few or absent sweat glands. Because dogs only have sweat glands on their paw pads, they are…

Seen in German Shepherd Dogs, but not Sophie.

Renal Cystadenocarcinoma and Nodular Dermatofibrosis (RCND)
(FLCN Exon 7)
Multisystem

A multiorgan syndrome best described in the German Shepherd Dog, affected dogs display thick skin nodules and signs of kidney disease, and should be evaluated by a veteri…

Seen in German Shepherd Dogs, but not Sophie.

Mucopolysaccharidosis Type VII, Sly Syndrome
(GUSB Exon 3)
Multisystem

A type of lysosomal storage disease, this can cause skeletal abnormalities, growth retardation, and gait abnormalities, and can require close monitoring and special measu…

Seen in German Shepherd Dogs, but not Sophie.

Neuronal Ceroid Lipofuscinosis 1, Cerebellar Ataxia - NCL-A
(ARSG Exon 2)
Multisystem

This form of lysosomal storage disease can cause juvenile to adult-onset neurologic signs, depending on the affected gene. While lipofuscin is commonly observed in the ti…

Seen in American Staffordshire Terriers, but not Sophie.

GM1 Gangliosidosis
(GLB1 Exon 15 Alaskan Husky Variant)
Multisystem

An early onset form of lysosomal storage disease, this can cause affected dogs to display neurologic signs as puppies or young adults. These include partial or total visi…

Seen in Siberian Huskys, but not Sophie.

Hereditary Sensory Autonomic Neuropathy (HSAN), Acral Mutilation Syndrome
(GDNF-AS)
Brain and Spinal Cord

A rare condition affecting the ability to feel pain, HSAN has been diagnosed in French Spaniels, English Springer Spaniels, English Pointers, and German Shorthaired Point…

Seen in German Shorthaired Pointers, but not Sophie.

Malignant Hyperthermia
(RYR1)
Metabolic

This condition only manifests if affected dogs are treated with certain inhalant anesthetics, and can cause uncontrollable muscle contractions and a dangerous increase in…

Seen in Rat Terriers, Siberian Huskys, German Shorthaired Pointers, American Staffordshire Terriers, German Shepherd Dogs, Collies, Chow Chows, but not Sophie.

Other Conditions: Clear of 146

Sophie is clear of 146 other genetic diseases that Embark tests for.

Explore:

Family tree

Traits

Maternal Haplotype

Paternal Haplotype

Jump to:

Coat Color

A number of genes are known to affect coat color in dogs, and they all interact. In some cases, other genetic effects may also influence color and pattern.

Trait
Result
 
E Locus (Mask, Grizzle, Recessive Red)
Eme
K Locus (Dominant Black)
kyky
A Locus (Agouti, Sable)
atat
D Locus (Dilute, Blue, Fawn)
DD
B Locus (Brown, Chocolate, Liver, Red)
Bb

Other Embark dogs with these Coat Color genes:

Other Coat Traits

Furnishings, shedding and curls are all genetic! And they all interact, too. In fact, the combination of these genes explains the coat phenotypes of 90% of AKC registered dog breeds.

Trait
Result
 
Furnishings / Improper Coat (RSPO2)
II
Long Haircoat (FGF5)
GT
Shedding (MC5R)
CT
Curly Coat (KRT71)
CC
Hairlessness (FOXI3)
LINKAGE
N/N

More information on coat type genetics: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897713/figure/F3/

Other Embark dogs with these Coat Traits genes:

Other Body Features

Trait
Result
 
Brachycephaly (BMP3)
CC
Natural Bobtail (T)
CC
Hind Dewclaws (LMBR1)
CC
Blue Eye Color
LINKAGE
N/N

Body Size

Body size is a complex trait that is affected by both genetic and environmental variation. Our genetic analysis includes genes that, together, explain over 80% of the variation in dog body size. It does not account for runting or stunting; nor does it account for the interactions between various genes both known and unknown.

Trait
Result
 
Body Size - IGF1
NI
Body Size - IGF1R
GA
Body Size - STC2
TT
Body Size - GHR (E195K)
GG
Body Size - GHR (P177L)
CC

Other Embark dogs with these Body Size genes:

Performance

Trait
Result
 
Altitude Adaptation (EPAS1)
GG

Explore:

Family tree

Health

Maternal Haplotype

Paternal Haplotype

Through Sophie’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A2

Haplotype

A29a

Map

A2

Sophie’s Haplogroup

A2 is a very ancient maternal line. Most likely it was one of the major female lines that contributed to the very first domesticated dogs in Central Asia about 15,000 years ago. Some of the line stayed in Central Asia to the present day, and frequently appear as Tibetan Mastiffs and Akitas. Those that escaped the mountains of Central Asia sought out other cold spots, and are now found among Alaskan Malamutes and Siberian Huskies. This lineage is also occasionally found in several common Western breeds, such as German Shepherds and Labrador Retrievers. Curiously, all New Guinea Singing Dogs descend from this line. These are an ancient and very interesting breed found in the mountains of Papua New Guinea. Unfortunately, they are now endangered. They are closely related to the Australian dingo, so you could say its cousins are dingos! This line is also common in village dogs in Southeast and East Asia. Unlike many other lineages, A2 did not spread across the whole world, probably because it did not have the opportunity to hitch its wagon to European colonialism - or because these dogs just prefer hanging out in mountains, tundras, islands, and other hard-to-reach places!

A29a

Sophie’s Haplotype

Part of the A2 haplogroup, this haplotype occurs most commonly in Siberian Huskies, Alaskan Malamutes, Labrador Retrievers, and village dogs from Alaska.

Some other Embark dogs with this haplotype:

Dingos commonly possess this haplogroup.

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Family tree

Health

Traits

Paternal Haplotype

This 'Paternal Haplotype' tab is for deep ancestral lineage going back thousands of years.

For recent ancestry—"What breeds did my dog inherit from her mom and dad?"—please refer to the Breed, Family Tree, or Summary tab.

The Paternal Haplotype refers to a dog’s deep ancestral lineage stretching back thousands of years, before there were any distinct breeds of dog. We determine the Paternal Haplotype by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Sophie is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

Explore:

Family tree

Health

Traits

Maternal Haplotype