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Sophia

Lagotto Romagnolo

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Registration

American Kennel Club (AKC):

Genetic Breed Result

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Lagotto Romagnolo

Lagotto Romagnolos are an Italian breed of dog from the Romagna region of Italy. Sporting curly hair and charming faces, they were originally bred as hunting dogs during the Medieval Period; however, today they are mostly kept as pets and as a different kind of hunting dog—Lagotto Romagnolos are expert truffle dogs. Their wonderful sense of smell makes them a great candidate for finding and unearthing truffles, rare and expensive mushrooms that are considered culinary delicacies.

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Here’s what Sophia’s family tree may have looked like.
While there may be other possible configurations of her family’s relationships, this is the most likely family tree to explain Sophia’s breed mix.
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Health Summary

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Sophia is at increased risk for one genetic health condition.

Intervertebral Disc Disease (Type I)

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Sophia inherited both copies of the variant we tested

What does this result mean?

Follow-up by our experts indicates that this genetic variant is associated with an increase to Sophia’s risk for developing Intervertebral Disc Disease (Type I).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Sophia have not yet been the focus of research studies, our data indicates that Sophia is likely to be at increased risk.

Impact on Breeding

While further investigation is warranted to determine the clinical presentation and penetrance in Sophia’s breed, we recommend taking this genetic result into account when making breeding decisions.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Breed-Relevant Genetic Conditions

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Urate Kidney & Bladder Stones (SLC2A9)

Identified in Lagotto Romagnolos

Lagotto Storage Disease (ATG4D)

Identified in Lagotto Romagnolos

Juvenile Epilepsy (LGI2)

Identified in Lagotto Romagnolos

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

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Through Sophia’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A426

Map

A1d

Sophia’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A426

Sophia’s Haplotype

Part of the A1d haplogroup, this haplotype occurs most frequently in mixed-breed dogs.

The vast majority of Rottweilers have the A1d haplogroup.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Sophia inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Sophia is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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