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Sebastian

Coton de Tulear

“Sebastian loves life”

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Genetic Breed Result

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Coton de Tulear

The Coton de Tulear is a smaller breed with a cotton-like coat and lovable personality. They come from Madagascar, where they have been everything from pets of the royal family to free-ranging street dogs. They’re known as the “Royal Dog of Madagascar” and have been honored as such on a postage stamp.

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Changes to this dog’s profile
  • On 11/28/2017 changed name from "Sebastian " to "Sebastian"

Health Summary

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Sebastian has one variant that you should let your vet know about.

ALT Activity

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Sebastian inherited one copy of the variant we tested

Why is this important to your vet?

Sebastian has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Sebastian has this genotype, as ALT is often used as an indicator of liver health and Sebastian is likely to have a lower than average resting ALT activity. As such, an increase in Sebastian’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in Coton de Tulears

Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Coton de Tulears

Canine Multifocal Retinopathy, cmr2 (BEST1 Exon 5, Coton de Tulear Variant)

Identified in Coton de Tulears

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Coton de Tulears

Primary Hyperoxaluria (AGXT)

Identified in Coton de Tulears

Intervertebral Disc Disease (Type I) (FGF4 retrogene - CFA12)

Identified in Coton de Tulears

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Sebastian’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B1/13

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B1

Sebastian’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B1/13

Sebastian’s Haplotype

Part of the large B1 haplogroup, this common haplotype occurs in Shih Tzus, Tibetan Spaniels, Maltese, and village dogs throughout the world including Central and South America, South Asia, and the South Pacific.

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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Through Sebastian’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2b

Haplotype

Hc.9

Map

A2b

Sebastian’s Haplogroup

A2b appears to have split a few times in succession, which means that some of the Central Asian male ancestors of this lineage went their separate ways before their respective Y chromosomes made their rounds. There is not much diversity in this lineage, meaning that it has only begun to take off recently. Two iconic breeds, the Dachshund and Bloodhound, represent this lineage well. Over half of Rottweilers are A2b, as are the majority of Labrador Retrievers and Cavalier King Charles Spaniels. While A2a is restricted mostly to East Asia, this paternal line is also found among European breeds.

Hc.9

Sebastian’s Haplotype

Part of the A2b haplogroup, this haplotype is found in village dogs spanning South America, Africa, and the South Pacific. Among the breeds we have spotted it in, the most frequent occurrences are in Dachshund, Bloodhound, American Eskimo Dog, and Jack Russell Terrier.

A2b is found in the Daschund breed.

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