What is Embark?

“Ace”
Sanlyn When Nature Calls

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See what’s hidden in the pages of Ace’s DNA story.

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Registration

New Zealand Kennel Club / Dogs New Zealand: 06380-2016

Genetic Breed

Schipperke

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Genetic Stats

Wolfiness: 2.0 % HIGH
Predicted Adult Weight: 19 lbs
Genetic Age: 25 human years

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Health

>
We have tested Ace for over 160 genetic health conditions to alert his owner to potential issues before they strike.

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Breed Families

>
Dog breeds have been created over time for work and companionship. Find out about other dog breeds related to the breeds found in Ace.

Maternal Haplotype

>
Through the DNA inherited from Ace’s mother we can trace his ancestry back to where dogs and people first became friends. Find out how far Ace’s family has traveled.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Ace’s DNA includes a story of where his father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

Let us know and we will contact Ace’s owner and make sure he is reunited with his family soon! Thank you for helping out our furry friends.

What’s your dog’s story?

Now that you have explored what’s behind Ace find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

Summary

0
AT RISK
1
CARRIER
164
CLEAR
Tap above or scroll down to see more

Clinical traits

These genetic traits are valuable to your veterinarian and can inform the clinical decisions and diagnoses they make.

Alanine Aminotransferase Activity result: Low Normal
Known to be highly expressed in liver cells, activity levels of alanine aminotransferase, or ALT, is a common value on most blood chemistry panels and is known to be a se…
Sanlyn When Nature Calls has one copy of a mutation associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian…

Not At Risk

Good news! Ace did not test positive for any of the genetic diseases that Embark screens for. Read on to learn more about the conditions we test for, but rest assured that Ace does not have the mutations known to cause them.

It is still important to let your veterinarian know these results because they could help guide Ace’s diagnosis and treatment if he gets sick in the future. Many other diseases caused by environmental factors or undiscovered genetic variants can cause symptoms similar to diseases we test for. By ruling out these mutations, your veterinarian will be able to find the true cause more quickly. Your veterinarian will also know they can safely prescribe medications some dogs are sensitive to.

Carrier for 1 genetic condition

Ace is a carrier for 1 of the genetic diseases that Embark tests for.
What does Carrier mean?

Ace has inherited a recessive allele for a genetic trait or mutation. This is not enough to cause symptoms of the disease, but is important to bear in mind if Ace ever has children.

Condition List

Canine Multifocal Retinopathy
cmr1 (BEST1 Exon 2)
Eyes

This is a nonprogressive retinal disease that, in rare cases, can lead to vision loss. All known mutations lie in the BEST1 gene and are inherited in an autosomal recessi…

Common Conditions

Good news! Ace tested clear for 3 genetic conditions that are common in his breed.
Condition List

Progressive Retinal Atrophy - prcd
Progressive rod-cone degeneration (PRCD Exon 1)
Eyes

This retinal disease causes progressive, nonpainful vision loss. The retina contains the cells, photoreceptors, that collect information about light: that is, they are th…

Degenerative Myelopathy
(SOD1A)
Brain and Spinal Cord

A disease of mature dogs, this is a progressive degenerative disorder of the spinal cord that can cause muscle wasting and gait abnormalities. Affected dogs do not usuall…

Malignant Hyperthermia
(RYR1)
Metabolic

This condition only manifests if affected dogs are treated with certain inhalant anesthetics, and can cause uncontrollable muscle contractions and a dangerous increase in…

Other Conditions: Clear of 161

Ace is clear of 161 other genetic diseases that Embark tests for.

Explore more

Swipe left and right to explore more results, or choose a category below

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Breed Families

>
Dog breeds have been created over time for work and companionship. Find out about other dog breeds related to the breeds found in Ace.

Maternal Haplotype

>
Through the DNA inherited from Ace’s mother we can trace his ancestry back to where dogs and people first became friends. Find out how far Ace’s family has traveled.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Ace’s DNA includes a story of where his father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

What’s your dog’s story?

Now that you have explored what’s behind Ace find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

Coat Color

A number of genetic loci are known to affect coat color in dogs, and they all interact. In some cases, other genetic effects may also influence color and pattern.

E Locus (Mask, Grizzle, Recessive Red)
EmEm
Chromosome 5

Controls the characteristic melanistic mask seen in the German Shepherd and Pug as well as the grizzled "widow's peak" of the Afghan and Borzoi. Melanistic mask (Em) is dominant to grizzle (Eg) which is dominant to black (E) and red (e). Dogs that are EE or Ee are able to produce normal black pigment, but its distribution will be dependent on the genotypes at the K and A Loci. Dogs that are ee will be a shade of red or cream regardless of their genotype at K and A. The shade of red, which can range from a deep copper like the Irish Setter to the near-white of some Golden Retrievers, is dependent on other genetic factors including the Intensity (I) Locus, which has yet to be genetically mapped.

Want to help us map I Locus? If you haven't already, complete your ee pup's Embark profile with a photo! Remember, a picture is worth a thousand words!

Citations: Schmutz et al 2003 , Dreger and Schmutz 2010 ,

More information: http://www.doggenetics.co.uk/masks.html

K Locus (Dominant Black)
KBKB
Chromosome 16

Causes a dominant black coat. Dogs with a dominant KB allele have black coats regardless of their genotype at the A locus; the coat color of dogs homozygous for the recessive ky allele are controlled by A locus. Alleles: KB > ky

Citations: Candille et al 2007

More information: http://www.doggenetics.co.uk/black.htm

A Locus (Agouti, Sable)
ata
Chromosome 24

Determines whether hair pigment is produced in a banded red and black pattern or solid black. Fawn or sable (ay) is dominant to wolf sable (aw) which is dominant to black-and-tan (at), which is in turn dominant to recessive black (a).

Citations: Berryere et al 2005 , Dreger and Schmutz 2011 ,

More information: http://www.doggenetics.co.uk/tan.html

D Locus (Dilute, Blue, Fawn)
DD
Chromosome 25

Lightens a black coat to blue and a red coat to buff. A dilute phenotype requires two copies of the recessive d allele.

Citations: Drogemuller et al 2007

More information: http://www.doggenetics.co.uk/dilutes.html

B Locus (Brown, Chocolate, Liver, Red)
BB
Chromosome 11

Lightens a black coat to brown, chocolate or liver. The brown phenotype requires two copies of the recessive b allele. Red or cream dogs that carry two b alleles remain red or cream but have brown noses and footpads.

Citations: Schmutz et al 2002

More information: http://www.doggenetics.co.uk/liver.html

Other Coat Traits

Furnishings, shedding and curls are all genetic! And they all interact, too. In fact, the combination of these genetic loci explain the coat phenotypes of 90% of AKC registered dog breeds.

For more information on the genetics of coat types you can refer to https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897713/figure/F3/

Some other Embark dogs with this Coat Traits genotype:

Furnishings / Improper Coat (RSPO2)
II
Chromosome 13

Confers the distinguished moustache, beard, and eyebrows characteristic of breeds like the Schnauzer, Scottish Terrier, and Wire Haired Dachshund; only one copy of the dominant F allele is required for furnishings. The FI genotype is furnished but carries one allele for no furnishings, or improper coat. A dog with two I alleles has improper coat. The mutation is a 167-bp insertion which we measure indirectly using linked markers highly correlated with the insertion.

Citations: Cadieu et al 2010

Long Haircoat (FGF5)
GG
Chromosome 32

The FGF5 gene is known to affect hair length in many different species, including cats, dogs, mice, and humans! The "T" allele confers a long, silky haircoat as observed in the Yorkshire Terrier and the Long Haired Whippet. The ancestral "G" allele causes a shorter coat as seen in the Boxer or the American Staffordshire Terrier.

Citations: Housley & Venta 2006 , Cadieu et al 2010

Shedding (MC5R)
CC
Chromosome 1

Affects shedding propensity in non-wire-haired dogs. Dogs with the ancestral C allele, like many Labradors and German Shepherd Dogs, are heavy or seasonal shedders, while those with one or more T allele, including many Boxers, Shih Tzus and Chihuahuas, tend to be low shedders. Dogs with furnished/wire-haired coats tend to be low shedders regardless of their MC5R genotype.

Citations: Hayward et al 2016

Curly Coat (KRT71)
CC
Chromosome 27

Causes the curly coat characteristic of Poodles and Bichons Frises. Dogs need at least one copy of the "T" allele to have a wavy or curly coat; the ancestral "C" allele is associated with a straight coat.

Citations: Cadieu et al 2010

Other Body Features

Brachycephaly (BMP3)
AA
Chromosome 32

Affects skull size and shape. Many brachycephalic or "smushed face” breeds such as the English Bulldog, Pug, and Pekingese have two copies of the derived A allele. Mesocephalic (Staffordshire Terrier, Labrador) and dolichocephalic (Whippet, Collie) dogs have one, or more commonly two, copies of the ancestral C allele. At least five different genes affect snout length in dogs, with BMP3 being the only one with a known causal mutation. For example, the skull shape of some breeds, including the dolichocephalic Scottish Terrier or the brachycephalic Japanese Chin, appear to be caused by other genes.

Citations: Schoenbeck et al 2012

Natural Bobtail (T)
CC
Chromosome 1

Whereas most dogs have two C alleles and a long tail, dogs with one G allele are likely to have a bobtail, which is an unusually short or absent tail. This mutation causes natural bobtail in many breeds including the Pembroke Welsh Corgi, the Australian Shepherd, and the Brittany Spaniel. Dogs with GG genotypes have not been observed, suggesting that the GG genotype results in embryonic lethality.

Please note that this mutation does not explain every natural bobtail! While certain lineages of Boston Terrier, English Bulldog, Rottweiler, Miniature Schnauzer, Cavalier King Charles Spaniel, and Parson Russell Terrier, and Dobermans are born with a natural bobtail, these breeds do not have this mutation. This suggests that other unknown genetic mutations can also lead to a natural bobtail. If your dog does not have a CG genotype but was born with a bobtail, please email us at howdy@embarkvet.com!

Citations: Haworth et al 2001 , Hytonen et al 2009

Hind Dewclaws (LMBR1)
CC
Chromosome 16

Common in certain breeds, hind dewclaws are extra, nonfunctional digits located midway between your dog's paw and hock. Dogs with at least one copy of the T allele have about a 50% of chance of having hind dewclaws.

Citations: Park et al 2008

Body Size

Body size is a complex trait that is affected by both genetic and environmental variation. Our genetic analysis includes genes that, together, explain over 80% of the variation in dog body size. It does not account for runting or stunting; nor does it account for the interactions between various genes both known and unknown.

Some other Embark dogs with this Body Size genotype:

Body Size - IGF1
II
Chromosome 15

The "I" allele is associated with smaller size.

Citations: Sutter et al 2007

Body Size - IGF1R
GG
Chromosome 3

The "A" allele is associated with smaller size.

Citations: Hoopes et al 2012

Body Size - STC2
TA
Chromosome 4

The "A" allele is associated with smaller size.

Citations: Rimbault et al 2013

Body Size - GHR (E195K)
GG
Chromosome 4

The "A" allele is associated with smaller size.

Citations: Rimbault et al 2013

Body Size - GHR (P177L)
CC
Chromosome 4

The "T" allele is associated with smaller size.

Citations: Rimbault et al 2013

Performance

Altitude Adaptation (EPAS1)
GG
Chromosome 10

Confers hypoxia tolerance. Dogs with at least one A allele are more tolerant of high altitude environments. This mutation was originally identified in breeds from high altitude areas such as the Tibetan Mastiff.

Citations: Gou et al 2014

Explore more

Swipe left and right to explore more results, or choose a category below

Health

>
We have tested Ace for over 160 genetic health conditions to alert his owner to potential issues before they strike.

Breed Families

>
Dog breeds have been created over time for work and companionship. Find out about other dog breeds related to the breeds found in Ace.

Maternal Haplotype

>
Through the DNA inherited from Ace’s mother we can trace his ancestry back to where dogs and people first became friends. Find out how far Ace’s family has traveled.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Ace’s DNA includes a story of where his father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

What’s your dog’s story?

Now that you have explored what’s behind Ace find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

DNA shows us the unique path to each of today’s recognized breeds by exposing the relatedness between them.
Schipperke
5 related breeds
Schipperke
The Schipperke is a small spitz-looking breed from Belgium. These guys were used as watch dogs and ratters, but today they can primarily be found as charming companions.
Related Breeds
Pomeranian
Cousin breed
Chihuahua
Cousin breed
Pekingese
Cousin breed
Chinese Crested
Cousin breed
Alaskan Klee Kai
Cousin breed

Some images and text courtesy of the AKC, used with permission.

Explore more

Swipe left and right to explore more results, or choose a category below

Health

>
We have tested Ace for over 160 genetic health conditions to alert his owner to potential issues before they strike.

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Maternal Haplotype

>
Through the DNA inherited from Ace’s mother we can trace his ancestry back to where dogs and people first became friends. Find out how far Ace’s family has traveled.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Ace’s DNA includes a story of where his father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

What’s your dog’s story?

Now that you have explored what’s behind Ace find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

Through Ace’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A18/19/20/21/27/36/94/109

Map

A1b

Sanlyn When Nature Calls’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A18/19/20/21/27/36/94/109

Sanlyn When Nature Calls’s Haplotype

Part of the large A1b haplogroup, we see this haplotype in village dogs in over 25 countries across the world. We have detected this haplotype in lots of breeds, and it occurs most commonly in German Shepherd Dogs, Maltese, English Springer Spaniels, and English Setters.

Some other Embark dogs with this haplotype:

A1b is the most common haplogroup found in German Shepherds.

Explore more

Swipe left and right to explore more results, or choose a category below

Health

>
We have tested Ace for over 160 genetic health conditions to alert his owner to potential issues before they strike.

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Breed Families

>
Dog breeds have been created over time for work and companionship. Find out about other dog breeds related to the breeds found in Ace.

Paternal Haplotype

>
The Y-Chromosome is only passed down from father to son. Ace’s DNA includes a story of where his father’s ancestors came from. We’ll show you more about how we categorize his ancestors all based of the science of genetics.

What’s your dog’s story?

Now that you have explored what’s behind Ace find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!

Through Ace’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

Ha.8

Map

A1b

Sanlyn When Nature Calls’s Haplogroup

For most of dog history, this haplogroup was probably quite rare. However, a couple hundred years ago it seems to have found its way into a prized male guard dog in Europe who had many offspring, including the ancestors of many European guard breeds such as Doberman Pinchers, St. Bernards, and Great Danes. Despite being rare, many of the most imposing dogs on Earth have it; strangely, so do many Pomeranians! Perhaps this explains why some Poms are so tough, acting like they're ten times their actual size! This lineage is most commonly found in working dogs, in particular guard dogs. With origins in Europe, it spread widely across other regions as Europeans took their dogs across the world.

Ha.8

Sanlyn When Nature Calls’s Haplotype

Part of the A1b haplogroup, this rare haplotype occurs most often in Schipperkes and village dogs in Croatia.

Some other Embark dogs with this haplotype:

Great Danes and Pomeranians have this in common!

Explore more

Swipe left and right to explore more results, or choose a category below

Health

>
We have tested Ace for over 160 genetic health conditions to alert his owner to potential issues before they strike.

Traits

>
Genes for coat color and type, body size and shape, and other characteristics.

Breed Families

>
Dog breeds have been created over time for work and companionship. Find out about other dog breeds related to the breeds found in Ace.

Maternal Haplotype

>
Through the DNA inherited from Ace’s mother we can trace his ancestry back to where dogs and people first became friends. Find out how far Ace’s family has traveled.

What’s your dog’s story?

Now that you have explored what’s behind Ace find out what your dog’s DNA has to tell you. Embark tells you more about your dog than you ever thought possible. Are you ready? Let’s go!