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“Harley Quinn”
Gotham’s Known to be Vexing

Poodle (Standard)

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Genetic Breed Result

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Poodle (Standard)

Known as the national dog breed of France, poodles were developed in Germany and are known for their loyalty and distinctive coat.

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Changes to this dog’s profile
  • On 1/8/2022 changed handle from "louisesprobablepoodle" to "saltydoodleharleyquinn"
  • On 1/8/2022 changed name from "Sapphire" to "Gotham’s Known to be Vexing"
  • On 11/27/2021 changed name from "Louises phantom poodle" to "Sapphire"
  • On 11/24/2021 changed name from "Louises probable poodle" to "Louises phantom poodle"

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Health Summary

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Harley Quinn inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Degenerative Myelopathy, DM

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Harley Quinn inherited one copy of the variant we tested

What does this result mean?

This result should not impact Harley Quinn’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Harley Quinn inherited both copies of the variant we tested

Why is this important to your vet?

Harley Quinn has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Harley Quinn's ALT activity above their current, healthy, ALT activity. As an increase above Harley Quinn’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in Standard Poodles

Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Standard Poodles

GM2 Gangliosidosis (HEXB, Poodle Variant)

Identified in Standard Poodles

Neonatal Encephalopathy with Seizures, NEWS (ATF2)

Identified in Standard Poodles

Osteochondrodysplasia (SLC13A1, Poodle Variant)

Identified in Standard Poodles

Intervertebral Disc Disease (Type I) (FGF4 retrogene - CFA12)

Identified in Standard Poodles

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Harley Quinn’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B49

Map

B1

Gotham’s Known to be Vexing’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B49

Gotham’s Known to be Vexing’s Haplotype

Part of the large B1 haplogroup, this haplotype occurs most commonly in Poodles. It’s a rare find!

Some other Embark dogs with this haplotype:

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Harley Quinn inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Harley Quinn is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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