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Sadie

Mixed Ancestry

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Place of Birth

Marysville, CA, USA

Current Location

Marysville, CA, USA

From

Marysville, CA, USA

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Genetic Breed Result

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Poodle (Standard)

Known as the national dog breed of France, poodles were developed in Germany and are known for their loyalty and distinctive coat.

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Poodle (Small)

A highly intelligent and playful dog, Miniature and Toy Poodles make for great lap dogs and companions.

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Cocker Spaniel

Cocker Spaniels are handsome and intelligent hunting dogs that are also well-suited to life as a loving family pet.

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Labrador Retriever

The Labrador Retriever was bred for hunting and excelled in retrieving game after it was shot down. Known for its gentle disposition and loyalty, the Labrador Retriever has become a favorite of families and breeders alike.

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Genetic Stats

Predicted Adult Weight

40 lbs

Genetic Age
27 human years

Based on the date of birth provided

DNA Breed Origins

Breed colors:
Poodle (Standard)
Poodle (Small)
Cocker Spaniel
Labrador Retriever

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Health Summary

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Sadie has one variant that you should let your vet know about.

ALT Activity

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Sadie inherited one copy of the variant we tested

Why is this important to your vet?

Sadie has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Sadie has this genotype, as ALT is often used as an indicator of liver health and Sadie is likely to have a lower than average resting ALT activity. As such, an increase in Sadie’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in Standard Poodles and Small Poodles

Canine Elliptocytosis (SPTB Exon 30)

Identified in Labrador Retrievers

Pyruvate Kinase Deficiency (PKLR Exon 7, Labrador Retriever Variant)

Identified in Labrador Retrievers

Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Cocker Spaniels, Labrador Retrievers, and more

Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2 (TTC8)

Identified in Labrador Retrievers

Progressive Retinal Atrophy, crd4/cord1 (RPGRIP1)

Identified in Labrador Retrievers

Day Blindness (CNGA3 Exon 7, Labrador Retriever Variant)

Identified in Labrador Retrievers

Macular Corneal Dystrophy, MCD (CHST6)

Identified in Labrador Retrievers

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Labrador Retrievers

Familial Nephropathy (COL4A4 Exon 3, Cocker Spaniel Variant)

Identified in Cocker Spaniels

Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency (PFKM, Whippet and English Springer Spaniel Variant)

Identified in Cocker Spaniels

GM2 Gangliosidosis (HEXB, Poodle Variant)

Identified in Standard Poodles and Small Poodles

Alexander Disease (GFAP)

Identified in Labrador Retrievers

Degenerative Myelopathy, DM (SOD1A)

Identified in Standard Poodles

Neonatal Encephalopathy with Seizures, NEWS (ATF2)

Identified in Standard Poodles and Small Poodles

Narcolepsy (HCRTR2 Intron 6, Labrador Retriever Variant)

Identified in Labrador Retrievers

Acral Mutilation Syndrome (GDNF-AS, Spaniel and Pointer Variant)

Identified in Cocker Spaniels

Centronuclear Myopathy, CNM (PTPLA)

Identified in Labrador Retrievers

Exercise-Induced Collapse, EIC (DNM1)

Identified in Cocker Spaniels and Labrador Retrievers

X-Linked Myotubular Myopathy (MTM1, Labrador Retriever Variant)

Identified in Labrador Retrievers

Congenital Myasthenic Syndrome, CMS (COLQ, Labrador Retriever Variant)

Identified in Labrador Retrievers

Hereditary Nasal Parakeratosis, HNPK (SUV39H2)

Identified in Labrador Retrievers

Osteochondrodysplasia (SLC13A1, Poodle Variant)

Identified in Standard Poodles and Small Poodles

Skeletal Dysplasia 2, SD2 (COL11A2, Labrador Retriever Variant)

Identified in Labrador Retrievers

Intervertebral Disc Disease (Type I) (FGF4 retrogene - CFA12)

Identified in Cocker Spaniels, Standard Poodles, and more

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Sadie’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

C2

Haplotype

C42/54/55

Map

C2

Sadie’s Haplogroup

C2 is a very old female lineage found more commonly among English Setters, English Bulldogs, and American Eskimo Dogs. We also see C2 in village dogs in South Asia. Rather than having a few characteristic breeds representing this lineage particularly well, it is present in a few uncommon individuals of many different breeds. Unlike some European breed lineages that have seen skyrocketing popularity along the path to the modern dogs we see today, C2 tends to reflect the deep history of man's best friend.

C42/54/55

Sadie’s Haplotype

Part of the C2 haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

You can often find his haplogroup in the lovable English Bulldog.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Sadie inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Sadie is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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