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“DEMON”
WINTER WHITE WOLF DEMON

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“The demon is a wolf-dog mix. descendant of the Perm Wolfdog, who were in the Perm Military Institute. HD - A, ED - 0; EYES - CLEAR DW — CLEAR Color genotype — ky/ky, Ays/at³, eA/e³, B/bs, D/D, m/m”

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@ruswolfdog

Place of Birth

Санкт-Петербург, Россия

Current Location

Пермь, Пермский край, Россия

From

Санкт-Петербург, Russia

This dog has been viewed and been given 36 wags

Registration

N/A : WWW666
Microchip: 643090000270593

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Changes to this dog’s profile
  • On 1/17/2022 changed handle from "wolfdog_demon" to "rwd_demon"
  • On 2/3/2020 changed name from "Demon" to "WINTER WHITE WOLF DEMON"
  • On 2/3/2020 changed name from "Winter White Wolf Demon" to "Demon"
  • On 1/25/2020 changed name from "Demon" to "Winter White Wolf Demon"
  • On 12/19/2019 changed handle from "demon10" to "wolfdog_demon"

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Health Summary

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DEMON inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Collie Eye Anomaly

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DEMON inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), DEMON is unlikely to develop this condition due to the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Collie Eye Anomaly?

Named for its high prevalence in Collie dogs, Collie Eye Anomaly (CEA) is more correctly termed choroidal hypoplasia. The choroid anchors the retina to the underlying structures and supplies it with oxygen and nourishment. CEA is a developmental disease of the choroid.

ALT Activity

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DEMON inherited both copies of the variant we tested

Why is this important to your vet?

DEMON has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in DEMON's ALT activity above their current, healthy, ALT activity. As an increase above DEMON’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity (ABCB1)

Identified in German Shepherd Dogs

Hemophilia A (F8 Exon 11, German Shepherd Variant 1)

Identified in German Shepherd Dogs

Hemophilia A (F8 Exon 1, German Shepherd Variant 2)

Identified in German Shepherd Dogs

Canine Leukocyte Adhesion Deficiency Type III, CLAD III (FERMT3, German Shepherd Variant)

Identified in German Shepherd Dogs

Platelet Factor X Receptor Deficiency, Scott Syndrome (TMEM16F)

Identified in German Shepherd Dogs

X-Linked Progressive Retinal Atrophy 1, XL-PRA1 (RPGR)

Identified in Siberian Huskies

Day Blindness (CNGA3 Exon 7, German Shepherd Variant)

Identified in German Shepherd Dogs

Urate Kidney & Bladder Stones (SLC2A9)

Identified in German Shepherd Dogs

Anhidrotic Ectodermal Dysplasia (EDA Intron 8)

Identified in German Shepherd Dogs

Renal Cystadenocarcinoma and Nodular Dermatofibrosis (FLCN Exon 7)

Identified in German Shepherd Dogs

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 3, German Shepherd Variant)

Identified in German Shepherd Dogs

GM1 Gangliosidosis (GLB1 Exon 15, Alaskan Husky Variant)

Identified in Siberian Huskies

Degenerative Myelopathy, DM (SOD1A)

Identified in German Shepherd Dogs

Additional Genetic Conditions

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Coat Color

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