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“Ilva”
Ruby Lobo de la Luna Llena

Saarloos Wolfdog

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Place of Birth

Woudenberg, Nederland

Current Location

Beerta, Groningen, Nederland

From

Woudenberg, Nederland

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Genetic Breed Result

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Saarloos Wolfdog

Saarloos Wolfdogs are a Dutch breed of dog that are actually the result of the careful breeding of wolf/dog hybrids. In fact, they are the breed of dog that, according to a study conducted in 2015, contain the most genetic similarity to wolves.

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Health Summary

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Ilva is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Intervertebral Disc Disease (Type I)

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Ilva inherited one copy of the variant we tested

What does this result mean?

Follow-up by our experts indicates that this genetic variant is associated with an increase to Ilva’s risk for developing Intervertebral Disc Disease (Type I).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Ilva have not yet been the focus of research studies, our data indicates that Ilva is likely to be at increased risk.

Impact on Breeding

While further investigation is warranted to determine the clinical presentation and penetrance in Ilva’s breed, we recommend taking this genetic result into account when making breeding decisions.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Degenerative Myelopathy, DM

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Ilva inherited one copy of the variant we tested

What does this result mean?

This result should not impact Ilva’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity (ABCB1)

Identified in Saarloos Wolfdogs

Hemophilia A (F8 Exon 11, German Shepherd Variant 1)

Identified in Saarloos Wolfdogs

Hemophilia A (F8 Exon 1, German Shepherd Variant 2)

Identified in Saarloos Wolfdogs

Canine Leukocyte Adhesion Deficiency Type III, CLAD III (FERMT3, German Shepherd Variant)

Identified in Saarloos Wolfdogs

Platelet Factor X Receptor Deficiency, Scott Syndrome (TMEM16F)

Identified in Saarloos Wolfdogs

Day Blindness (CNGA3 Exon 7, German Shepherd Variant)

Identified in Saarloos Wolfdogs

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Saarloos Wolfdogs

Anhidrotic Ectodermal Dysplasia (EDA Intron 8)

Identified in Saarloos Wolfdogs

Renal Cystadenocarcinoma and Nodular Dermatofibrosis (FLCN Exon 7)

Identified in Saarloos Wolfdogs

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 3, German Shepherd Variant)

Identified in Saarloos Wolfdogs

Additional Genetic Conditions

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Clinical Tools

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Through Ilva’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

E

Haplotype

E11

Map

E

Ruby Lobo de la Luna Llena’s Haplogroup

Haplogroup E is a very rare maternal line, present primarily in Northern breed dogs and dogs with some level of recent gray wolf ancestry.

E11

Ruby Lobo de la Luna Llena’s Haplotype

The E haplogroup in general is not common. It has been found in dogs with some level of background mixing with its wolf-like ancestors.

Some other Embark dogs with this haplotype:

An example of an Akita.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Ilva inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Ilva is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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