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“Lucy”
Royal T's Lovable Lucy

Mi-Ki

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“Lucy is a beautiful black and tan Mi-Ki.”

Place of Birth

Castle Rock, CO, USA

Current Location

Elizabeth, CO, USA

From

Castle Rock, CO, USA

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Registration

N/A : 002065L20160823VP / P901-801
Microchip: 933000320062720

Genetic Breed Result

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Mi-Ki

Though the Mi-Ki breed is rare, with their cute looks and charming personality their popularity is ever increasing.

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Health Summary

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Lucy is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Intervertebral Disc Disease (Type I)

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Lucy inherited one copy of the variant we tested

What does this result mean?

Follow-up by our experts indicates that this genetic variant is associated with an increase to Lucy’s risk for developing Intervertebral Disc Disease (Type I).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Lucy have not yet been the focus of research studies, our data indicates that Lucy is likely to be at increased risk.

Impact on Breeding

While further investigation is warranted to determine the clinical presentation and penetrance in Lucy’s breed, we recommend taking this genetic result into account when making breeding decisions.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

ALT Activity

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Lucy inherited one copy of the variant we tested

Why is this important to your vet?

Lucy has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Lucy has this genotype, as ALT is often used as an indicator of liver health and Lucy is likely to have a lower than average resting ALT activity. As such, an increase in Lucy’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Additional Genetic Conditions

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Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Lucy’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

C2

Haplotype

C42/54/55

Map

C2

Royal T's Lovable Lucy’s Haplogroup

C2 is a very old female lineage found more commonly among English Setters, English Bulldogs, and American Eskimo Dogs. We also see C2 in village dogs in South Asia. Rather than having a few characteristic breeds representing this lineage particularly well, it is present in a few uncommon individuals of many different breeds. Unlike some European breed lineages that have seen skyrocketing popularity along the path to the modern dogs we see today, C2 tends to reflect the deep history of man's best friend.

C42/54/55

Royal T's Lovable Lucy’s Haplotype

Part of the C2 haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

You can often find his haplogroup in the lovable English Bulldog.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Lucy inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Lucy is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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