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“Aoma”
RoyalRarity's Aomaru

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Health Summary

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Aoma inherited two variants that you should learn more about.

And one variant that you should tell your vet about.

Von Willebrand Disease Type I, Type I vWD

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Aoma inherited one copy of the variant we tested

What does this result mean?

We do not know whether this increases the risk that Aoma will develop Von Willebrand Disease Type I, Type I vWD.

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. Not enough dogs with Aoma's breed have been studied to know whether or not this variant will increase Aoma's risk of developing this disease.

Impact on Breeding

Research into the clinical impact of this variant is ongoing. We recommend tracking this genetic result and incidence of Von Willebrand Disease Type I, Type I vWD in your breeding program and related dogs.

What is Von Willebrand Disease Type I, Type I vWD?

Von Willebrand Disease (vWD) is a type of coagulopathy, a disorder of blood clotting. vWD is characterized into three types based on clinical severity, serum levels of vWF, and vWF multimer composition. Dogs with Type I vWD have low vWF levels, normal multimer composition, and variable clinical signs.

Canine Multifocal Retinopathy, cmr1

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Aoma inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Aoma’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Aoma is unlikely to develop this condition due to this variant because she only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Canine Multifocal Retinopathy, cmr1?

This is a non-progressive retinal disease that, in rare cases, can lead to vision loss. Dogs with larger lesions can suffer from vision loss. CMR is fairly non-progressive; new lesions will typically stop forming by the time a dog is an adult, and some lesions will even regress with time.

ALT Activity

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Aoma inherited one copy of the variant we tested

Why is this important to your vet?

Aoma has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Aoma has this genotype, as ALT is often used as an indicator of liver health and Aoma is likely to have a lower than average resting ALT activity. As such, an increase in Aoma’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Methemoglobinemia (CYB5R3)

Identified in Pomeranians

Progressive Retinal Atrophy, rcd3 (PDE6A)

Identified in Pomeranians

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Pomeranians

Oculocutaneous Albinism, OCA (SLC45A2, Small Breed Variant)

Identified in Pekingese and Pomeranians

Hereditary Vitamin D-Resistant Rickets (VDR)

Identified in Pomeranians

Intervertebral Disc Disease (Type I) (FGF4 retrogene - CFA12)

Identified in Pekingese

Additional Genetic Conditions

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