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River

Mixed Breed

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“He was born on a farm and adopted at 10 weeks old”

Place of Birth

Summertown, TN, USA

Current Location

Chattanooga, Tennessee, USA

From

Murfreesboro, Tennessee, USA

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Genetic Breed Result

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Great Pyrenees

The Great Pyrenees is an exceptionally loving dog whose primary function is to protect sheep, goats, livestock, people, children, grass, flowers, the moon, lawn furniture, etc., from any real or imaginary predators that may intrude on your personal space. They have a strong build and an amazing thick white coat that exudes elegance and majesty. They make a great family dog because of their intelligence and steady temperament.

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Golden Retriever

Developed as an ideal hunting retriever, the Golden Retriever's eagerness to please and friendliness has made them an extremely popular family pet.

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Beagle

The Beagle is a scent hound and a great family pet. They are known for being affectionate and having loud voices.

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Dogs Like River

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Discover dogs who share a similar breed mix to River. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
Great Pyrenees
Golden Retriever
Beagle

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River
Family Tree From Embark PARENTS GRANDPARENTS GREAT GRANDPARENTS Great Pyrenees mix Golden Retriever mix Great Pyrenees Golden Retriever / Beagle mix Golden Retriever Great Pyrenees / Beagle mix Great Pyrenees Great Pyrenees Golden Retriever Beagle mix Golden Retriever Golden Retriever Great Pyrenees Beagle mix

Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain River’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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River is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Intervertebral Disc Disease (Type I)

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River inherited one copy of the variant we tested

How to interpret this result

River has one copy of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

ALT Activity

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River inherited one copy of the variant we tested

Why is this important to your vet?

River has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that River has this genotype, as ALT is often used as an indicator of liver health and River is likely to have a lower than average resting ALT activity. As such, an increase in River’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Factor VII Deficiency

Identified in Beagles

Glanzmann's Thrombasthenia Type I

Identified in Great Pyrenees

Pyruvate Kinase Deficiency

Identified in Beagles

Progressive Retinal Atrophy, prcd

Identified in Golden Retrievers

Golden Retriever Progressive Retinal Atrophy 1, GR-PRA1

Identified in Golden Retrievers

Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2

Identified in Golden Retrievers

Progressive Retinal Atrophy, crd4/cord1

Identified in Beagles

Canine Multifocal Retinopathy, cmr1

Identified in Great Pyrenees

Primary Open Angle Glaucoma

Identified in Beagles

Congenital Stationary Night Blindness

Identified in Beagles

Neuronal Ceroid Lipofuscinosis 5, NCL 5

Identified in Golden Retrievers

Neonatal Cerebellar Cortical Degeneration

Identified in Beagles

Degenerative Myelopathy, DM

Identified in Golden Retrievers and Great Pyrenees

Muscular Dystrophy

Identified in Golden Retrievers

Hypocatalasia, Acatalasemia

Identified in Beagles

Cobalamin Malabsorption

Identified in Beagles

Congenital Myasthenic Syndrome, CMS

Identified in Golden Retrievers

Dystrophic Epidermolysis Bullosa

Identified in Golden Retrievers

Ichthyosis, ICH1

Identified in Golden Retrievers

Musladin-Lueke Syndrome, MLS

Identified in Beagles

Osteogenesis Imperfecta

Identified in Beagles

Osteogenesis Imperfecta

Identified in Golden Retrievers

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through River’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A382

Map

A1a

River’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A382

River’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs most frequently in Labrador Retrievers, Golden Retrievers, and Chesapeake Bay Retrievers.

Some other Embark dogs with this haplotype:

Shar Pei dogs think A1a is the coolest!

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Through River’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

D

Haplotype

H7.2

Map

D

River’s Haplogroup

The D paternal lineage is very common in well-known populations of dogs. Breeds belonging to the D lineage likely have direct male ancestors that can be traced all the way back to the origin of domestic dogs themselves! One popular breed that commonly sports a D lineage is the Boxer. Boxers were developed in the late 19th century from Mastiff dogs, so it is no surprise that D is well represented among Mastiffs, Bulldogs, as well as Terriers. Intriguingly, D is also found among Lhasa Apsos, an ancient Tibetan breed, and Afghan Hounds. While the presence of this lineage in Polynesia or the New World can be chalked up to interbreeding with European dogs brought during voyages of discovery or later settlement, D is also well represented among village dog populations in the Middle East and Africa. If the fact that we find dogs bearing a D lineage in the Middle East (not to mention the large amount of diversity among Middle Eastern D lineage males) is any indication of ancient residence in that region, then the presence among Oceanian village dogs is peculiar. Rather, it may be that D is part of a broader Eurasian group of ancient paternal lineages which disappeared from the eastern portion of its original range, persisting in the island of New Guinea as well as West Asia and Africa. With the rise of Mastiff breeds, the D lineage received a new life as it became common among many types of working dogs.

H7.2

River’s Haplotype

Part of the D haplogroup, the H7.2 haplotype occurs most commonly in Sarplaninacs. We've also spotted it in Middle Eastern Village Dogs and European Village Dogs.

Some other Embark dogs with this haplotype:

The D paternal lineage is common in Boxers.

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