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“Ripley”
BIS U-GCH Melrae's Houston We Have A Problem RI RA BCAT DJ CGCA CGCU TKA WAC SPOT-ON RACEN RATI

Doberman Pinscher

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  • Photo of Ripley, a Doberman Pinscher  in Zeeland, MI, USA Photo of Ripley, a Doberman Pinscher  in Zeeland, MI, USA
    Winners Bitch - 14 months

“She is showing us she's a do it all Doberman. She's always happy, she's bold, she's sweet, touch of Doberman drama, touch of lovable velcro, miss confident and independent. From kissing kids and friendly strangers to a protector where appropriate. Nothing shakes her. She's a great partner and willing to try anything! Conformation, Dock Diving, Fast Cat, Rally, Agility, Nosework, Barnhunt... there's no stopping her.”

Instagram tag
@ripley_the_dobe

Place of Birth

Zeeland, MI, USA

Current Location

Cromwell, Indiana, USA

From

Zeeland, MI, USA

This dog has been viewed and been given 1 wag

Registration

American Kennel Club (AKC): WS69022504
Microchip: 956000012657118

Genetic Breed Result

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Doberman Pinscher

Doberman Pinschers are a strong and athletic breed that are built to guard and protect.

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Changes to this dog’s profile
  • On 9/14/2022 changed name from "BIS U-GCH Melrae's Houston We Have A Problem RI RA DJ BCAT CGCA TKA SPOT-ON RACEN RATI WAC" to "Melrae's Houston We Have A Problem"
  • On 9/14/2022 changed name from "UKC BIS U-GCH Melrae's Houston We Have A Problem RI BCAT CGCA TKA SPOT-ON RACEN RATI" to "BIS U-GCH Melrae's Houston We Have A Problem RI RA DJ BCAT CGCA TKA SPOT-ON RACEN RATI WAC"
  • On 3/22/2022 changed name from "UKC BIS U-GCH Melrae's Houston We Have A Problem RN RI CGC TKA SPOT-ON RACEN RATI" to "UKC BIS U-GCH Melrae's Houston We Have A Problem RI BCAT CGCA TKA SPOT-ON RACEN RATI"
  • On 1/30/2022 changed name from "U-GCH Melrae's Houston We Have A Problem RN RI CGC TKA SPOT-ON RACEN RATI" to "UKC BIS U-GCH Melrae's Houston We Have A Problem RN RI CGC TKA SPOT-ON RACEN RATI"
  • On 1/30/2022 changed name from "U-GCH Melrae's Houston We Have A Problem RN CGC TKA SPOT-ON RACEN RATI" to "U-GCH Melrae's Houston We Have A Problem RN RI CGC TKA SPOT-ON RACEN RATI"
  • On 1/6/2022 changed name from "U-CH Melrae's Houston We Have A Problem RN CGC TKA SPOT-ON RACEN RATI" to "U-GCH Melrae's Houston We Have A Problem RN CGC TKA SPOT-ON RACEN RATI"
  • On 11/2/2021 changed name from "U-CH Melrae's Houston We Have A Problem RN CGC TKA SPOT-ON RATI" to "U-CH Melrae's Houston We Have A Problem RN CGC TKA SPOT-ON RACEN RATI"
  • On 10/31/2021 changed name from "Melrae's Houston We Have A Problem" to "U-CH Melrae's Houston We Have A Problem RN CGC TKA SPOT-ON RATI"
  • On 10/31/2021 changed name from "Ripley" to "Melrae's Houston We Have A Problem"

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Health Summary

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Ripley is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Dilated Cardiomyopathy, DCM2

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Ripley inherited one copy of the variant we tested

How to interpret this result

Ripley has one copy of a variant in the TTN gene associated with increased risk for DCM in the American Doberman Pinscher. This variant, also referred to as DCM2, is inherited in a dominant manner, meaning having one or two copies of this variant is thought to confer the same amount of risk. However, the variant is thought to have incomplete penetrance: That is, not all dogs with this variant will ultimately show signs of DCM. Moreover, the impact of this variant in other breeds of dog besides the Doberman has yet to be fully understood. However, if your veterinarian thinks Ripley shows signs of having DCM based on their diagnostic testing, you now have the opportunity to discuss early treatment. Please consult with your veterinarian regarding a diagnostic and treatment plan for Ripley.

What is Dilated Cardiomyopathy, DCM2?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

Von Willebrand Disease Type I, Type I vWD

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Ripley inherited one copy of the variant we tested

What does this result mean?

This result should not impact Ripley’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Von Willebrand Disease Type I, Type I vWD?

Von Willebrand Disease (vWD) is a type of coagulopathy, a disorder of blood clotting. vWD is characterized into three types based on clinical severity, serum levels of vWF, and vWF multimer composition. Dogs with Type I vWD have low vWF levels, normal multimer composition, and variable clinical signs.

ALT Activity

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Ripley inherited one copy of the variant we tested

Why is this important to your vet?

Ripley has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Ripley has this genotype, as ALT is often used as an indicator of liver health and Ripley is likely to have a lower than average resting ALT activity. As such, an increase in Ripley’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Deafness and Vestibular Syndrome of Dobermans, DVDob, DINGS (MYO7A)

Identified in Doberman Pinschers

Narcolepsy (HCRTR2 Intron 4, Doberman Pinscher Variant)

Identified in Doberman Pinschers

Dilated Cardiomyopathy, DCM1 (PDK4, Doberman Pinscher Variant 1)

Identified in Doberman Pinschers

Ehlers Danlos (ADAMTS2, Doberman Pinscher Variant)

Identified in Doberman Pinschers

Additional Genetic Conditions

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Coat Color

Coat Color

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Performance

Performance

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Through Ripley’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B45

Map

B1

Melrae's Houston We Have A Problem’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B45

Melrae's Houston We Have A Problem’s Haplotype

Part of the large B1 haplogroup, this haplotype occurs most commonly in Yorkshire Terriers, Doberman Pinschers, Cocker Spaniels, and village dogs in Costa Rica.

Some other Embark dogs with this haplotype:

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Ripley inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Ripley is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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