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“Dooey”
RavenCreek VooDoo Magic for Island's

Sussex Spaniel

No bio has been provided yet

Place of Birth

Ennis, Montana, USA

Current Location

Knotts Island, North Carolina, USA

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Registration

American Kennel Club (AKC):
Microchip: 991001005366523

Genetic Breed Result

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Sussex Spaniel

The Sussex Spaniel is a breed of dog developed in Sussex in southern England. It is a low, compact spaniel and is similar in appearance to the Clumber Spaniel. They can be slow paced, but can have a clownish and energetic temperament.

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Health Summary

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Dooey is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Intervertebral Disc Disease (Type I)

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Dooey inherited one copy of the variant we tested

What does this result mean?

Follow-up by our experts indicates that this genetic variant is associated with an increase to Dooey’s risk for developing Intervertebral Disc Disease (Type I).

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Dooey have not yet been the focus of research studies, our data indicates that Dooey is likely to be at increased risk.

Impact on Breeding

While further investigation is warranted to determine the clinical presentation and penetrance in Dooey’s breed, we recommend taking this genetic result into account when making breeding decisions.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Skeletal Dysplasia 2, SD2

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Dooey inherited both copies of the variant we tested

What does this result mean?

We do not know whether this increases the risk that Dooey will develop Skeletal Dysplasia 2, SD2.

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. Not enough dogs with Dooey's breed have been studied to know whether or not this variant will increase Dooey's risk of developing this disease.

Impact on Breeding

Research into the clinical impact of this variant is ongoing. We recommend tracking this genetic result and incidence of Skeletal Dysplasia 2, SD2 in your breeding program and related dogs.

What is Skeletal Dysplasia 2, SD2?

A disease of skeletal development, this causes dogs to have abnormally short legs but similar body lengths compared to unaffected dogs.

ALT Activity

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Dooey inherited one copy of the variant we tested

Why is this important to your vet?

Dooey has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Dooey has this genotype, as ALT is often used as an indicator of liver health and Dooey is likely to have a lower than average resting ALT activity. As such, an increase in Dooey’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Pyruvate Dehydrogenase Deficiency (PDP1, Spaniel Variant)

Identified in Sussex Spaniels

Additional Genetic Conditions

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Traits

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Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

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Body Size

Body Size

Performance

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Through Dooey’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A414/643

Map

A1b

RavenCreek VooDoo Magic for Island's’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A414/643

RavenCreek VooDoo Magic for Island's’s Haplotype

Part of the A1b haplogroup, this haplotype occurs most frequently in the English Springer Spaniels.

A1b is the most common haplogroup found in German Shepherds.

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Through Dooey’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.14

Map

A1a

RavenCreek VooDoo Magic for Island's’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.14

RavenCreek VooDoo Magic for Island's’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs mainly in village dogs from Central and South Americas, but has also been spotted in Papua New Guinea. It also occurs frequently in Cocker Spaniels, English Cocker Spaniels, and Pembroke Welsh Corgis.

Dogs with A1a lineage travelled during European Colonial times.

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