Pippa inherited one copy of the variant we tested
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“Red Merle”
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Health Summary
Pippa is at increased risk for one genetic health condition.
And inherited two variants that you should learn more about.
Multiple Drug Sensitivity
How to interpret this result
Pippa has one copy of a variant at the ABCB1 gene and is at risk for displaying adverse drug reactions. While she may not be as severely affected as a dog with two copies of the ABCB1 drug sensitivity allele, normal dosages of drugs could still have potentially severe effects on Pippa. Please inform your veterinarian that Pippa carries this variant; it is essential that they know this information before prescribing drugs.
What is Multiple Drug Sensitivity?
Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with a mutation in the ABCB1 gene.
Degenerative Myelopathy, DM
Pippa inherited one copy of the variant we tested
What does this result mean?
This variant should not impact Pippa’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Pippa is unlikely to develop this condition due to this variant because she only has one copy of the variant.
What is Degenerative Myelopathy, DM?
The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.
ALT Activity
Pippa inherited one copy of the variant we tested
Why is this important to your vet?
Pippa has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Pippa has this genotype, as ALT is often used as an indicator of liver health and Pippa is likely to have a lower than average resting ALT activity. As such, an increase in Pippa’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.
What is ALT Activity?
Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.
Breed-Relevant Genetic Conditions
Progressive Retinal Atrophy, prcd
Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds
Variant not detected
Collie Eye Anomaly
Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds
Variant not detected
Canine Multifocal Retinopathy, cmr1
Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds
Variant not detected
Hereditary Cataracts
Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds
Variant not detected
Urate Kidney & Bladder Stones
Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds
Variant not detected
Neuronal Ceroid Lipofuscinosis 6, NCL 6
Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds
Variant not detected
Neuronal Ceroid Lipofuscinosis 8, NCL 8
Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds
Variant not detected
Craniomandibular Osteopathy, CMO
Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds
Variant not detected
Additional Genetic Conditions
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What is a linkage test?
DNA sequences that are close together on a chromosome tend to be inherited together. Because of this, we can use genetic variation surrounding a specific variant (i.e. "linked" to it) to infer the presence or absence of a variant that is associated with a health condition or trait.
Linkage tests are not as predictive of your dog’s true genotype as direct assays, which we use on most other genetic conditions we test for.
Traits
Explore the genetics behind your dog’s appearance and size.
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Base Coat Color
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Coat Color Modifiers
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Coat Traits
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Body Features
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Body Size
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.