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“PARKER”
Peter Benjamin Parker

Cavalier King Charles Spaniel

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Registration

AKC: TS44055601

Genetic Breed Result

Learn how it’s done

Cavalier King Charles Spaniel

100.0% Cavalier King Charles Spaniel
Cavalier King Charles Spaniel Cavalier King Charles Spaniel
The Cavalier King Charles Spaniel is an indoor companion that loves people and should not be left alone for long.
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Genetic Stats


Predicted Adult Weight
Genetic Age
17 human years Learn More
Based on the date of birth provided

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Breed Reveal Video

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Our algorithms predict this is the most likely family tree to explain PARKER’s breed mix, but this family tree may not be the only possible one.

Health Summary

PARKER is at increased risk for one genetic health condition.

And inherited three variants that you should learn more about.

Intervertebral Disc Disease (Type I)

PARKER inherited one copy of the variant we tested

How to interpret this result

PARKER has one copy of an FGF4 retrogene on chromosome 12 and is at increased risk for Type I IVDD. PARKER would also be expected to have an intermediate chondrodystrophic phenotype (slightly short legs relative to body length). Please consult with your veterinarian to discuss preventative and monitoring measures for PARKER.

What is Intervertebral Disc Disease (Type I)?

Chondrodystrophy (CDDY) refers to the relative proportions between dogs' legs and body. Dogs with chondrodystrophy have shorter legs and a longer body. An extreme example of this is a Dachshund or Corgi. Type I Intervertebral Disc Disease (IVDD) refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. The pressure on the spinal cord causes neurologic symptoms.

Congenital Macrothrombocytopenia

PARKER inherited one copy of the variant we tested

What does this result mean?

This result should not impact PARKER’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring.

What is Congenital Macrothrombocytopenia?

This is a benign disorder of platelet production that leads to abnormally large, sparse platelets.


Degenerative Myelopathy, DM

PARKER inherited one copy of the variant we tested

What does this result mean?

This result should not impact PARKER’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

This result should be taken into account as part of your breeding program. PARKER will pass this variant to ~50% of his offspring.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.


ALT Activity

PARKER inherited both copies of the variant we tested

Why is this important to your vet?

PARKER has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in PARKER's ALT activity above their current, healthy, ALT activity. As an increase above PARKER’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

Dry Eye Curly Coat Syndrome (FAM83H Exon 5)

Identified in Cavalier King Charles Spaniels

Muscular Dystrophy (DMD, Cavalier King Charles Spaniel Variant 1)

Identified in Cavalier King Charles Spaniels

Episodic Falling Syndrome (BCAN)

Identified in Cavalier King Charles Spaniels

Additional Genetic Conditions

Explore the genetics behind your dog’s appearance and size.
Coat Color

Coat Color

E Locus (MC1R)
No dark mask or grizzle (Ee)
K Locus (CBD103)
More likely to have a patterned haircoat (kyky)
A Locus (ASIP)
Black/Brown and tan coat color pattern (atat)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (DD)
B Locus (TYRP1)
Brown hair and skin (bb)
Saddle Tan (RALY)
Not saddle tan patterned (II)
M Locus (PMEL)
No merle alleles (mm)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely unfurnished (no mustache, beard, and/or eyebrows) (II)
Coat Length (FGF5)
Likely long coat (TT)
Shedding (MC5R)
Likely light to moderate shedding (TT)
Coat Texture (KRT71)
Likely straight coat (CC)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (CC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Unlikely to have hind dew claws (CC)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Smaller (II)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Smaller (AA)
Body Size (GHR - E191K)
Smaller (AA)
Body Size (GHR - P177L)
Smaller (TT)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)
Appetite (POMC) LINKAGE
Normal food motivation (NN)

Through PARKER’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A26a/305

Map

A1d

Peter Benjamin Parker’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A26a/305

Peter Benjamin Parker’s Haplotype

Part of the large A1d haplogroup, we have not yet detected this haplotype in any of our village dogs. Among the 6 breeds we see it in, it appears most frequently in Newfoundlands, Cavalier King Charles Spaniels, and soft coated Wheaten Terriers.

Some other Embark dogs with this haplotype:

The vast majority of Rottweilers have the A1d haplogroup.

Through PARKER’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2b

Haplotype

H3

Map

A2b

Peter Benjamin Parker’s Haplogroup

A2b appears to have split a few times in succession, which means that some of the Central Asian male ancestors of this lineage went their separate ways before their respective Y chromosomes made their rounds. There is not much diversity in this lineage, meaning that it has only begun to take off recently. Two iconic breeds, the Dachshund and Bloodhound, represent this lineage well. Over half of Rottweilers are A2b, as are the majority of Labrador Retrievers and Cavalier King Charles Spaniels. While A2a is restricted mostly to East Asia, this paternal line is also found among European breeds.

H3

Peter Benjamin Parker’s Haplotype

Part of the A2b haplogroup, this haplotype occurs most commonly in Cavalier King Charles Spaniels, Brittanys, Soft Coated Wheaten Terriers, and village dogs in Lebanon.

Some other Embark dogs with this haplotype:

A2b is found in the Daschund breed.