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Sunny inherited one copy of the variant we tested
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Place of Birth
Denver, Colorado, USA
Current Location
24316 200th Street, Long Prairie, MN 56347, USA
From
Denver, CO, USA
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Registration
American Kennel Club
(AKC):
HP45228003
Microchip: 074843344
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Health Summary
Sunny is at increased risk for one genetic health condition.
And inherited one variant that you should learn more about.
Intervertebral Disc Disease (Type I)
How to interpret this result
Sunny has one copy of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.
What is Intervertebral Disc Disease (Type I)?
Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.
ALT Activity
Sunny inherited one copy of the variant we tested
Why is this important to your vet?
Sunny has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Sunny has this genotype, as ALT is often used as an indicator of liver health and Sunny is likely to have a lower than average resting ALT activity. As such, an increase in Sunny’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.
What is ALT Activity?
Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.
Breed-Relevant Genetic Conditions
6 variants not detected
Progressive Retinal Atrophy, crd4/cord1 (RPGRIP1)
Identified in Dachshunds
Variant not detected
Mucopolysaccharidosis Type IIIA, Sanfilippo Syndrome Type A, MPS IIIA (SGSH Exon 6, Dachshund Variant)
Identified in Dachshunds
Variant not detected
Neuronal Ceroid Lipofuscinosis 1, NCL 1 (PPT1 Exon 8, Dachshund Variant 1)
Identified in Dachshunds
Variant not detected
Neuronal Ceroid Lipofuscinosis 2, NCL 2 (TPP1 Exon 4, Dachshund Variant 2)
Identified in Dachshunds
Variant not detected
Narcolepsy (HCRTR2 Exon 1, Dachshund Variant)
Identified in Dachshunds
Variant not detected
Osteogenesis Imperfecta (SERPINH1, Dachshund Variant)
Identified in Dachshunds
Variant not detected
Additional Genetic Conditions
188 variants not detected
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