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Otis

American Pit Bull Terrier (9.4% unresolved)

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  • Photo of Otis, an American Pit Bull Terrier (9.4% unresolved) in Munger, Michigan, USA Photo of Otis, an American Pit Bull Terrier (9.4% unresolved) in Munger, Michigan, USA
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“When we got Otis, we knew we weren’t told the truth about him. He was skin and bones, too weak to walk, play, and even bark. We had also noticed that he was terrified of men. With a strict high-protein diet, Otis is now very loyal to his owners, loves children, always full of energy, and loves adventuring, especially outdoors. He is getting a lot better around men, with a lot of work and patience. Otis is very food-motivated, and always willing to show you his high-fives.”

Place of Birth

Munger, Michigan, USA

Current Location

Sebewaing, Michigan, USA

From

Munger, Michigan, USA

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Genetic Breed Result

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Embark Supermutt analysis

What’s in that Supermutt? There may be small amounts of DNA from these distant ancestors:

American Pit Bull Terrier

The American Pit Bull Terrier originated in the British Isles and descends from the Mastiff-type dogs introduced to England in antiquity. The breed was brought over to the United States by English immigrants in the 1800s, and quickly became one of the most popular and widespread breeds there.

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Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain Otis’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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Otis inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Ichthyosis

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Otis inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Otis is unlikely to develop this condition due to the variant. This result may be important if you decide to breed this dog - we recommend genetic testing potential mates for this condition.

What is Ichthyosis?

This skin disorder gets its name from the thick, darkly pigmented scales of skin ("ichthys" is Greek for "fish") that affected dogs display on their noses, paw pads, and muzzles.

ALT Activity

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Otis inherited one copy of the variant we tested

Why is this important to your vet?

Otis has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Otis has this genotype, as ALT is often used as an indicator of liver health and Otis is likely to have a lower than average resting ALT activity. As such, an increase in Otis’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, crd1

Identified in American Pit Bull Terriers

Urate Kidney & Bladder Stones

Identified in American Pit Bull Terriers

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A

Identified in American Pit Bull Terriers

L-2-Hydroxyglutaricaciduria, L2HGA

Identified in American Pit Bull Terriers

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Otis’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A248

Map

A1d

Otis’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A248

Otis’s Haplotype

Part of the large A1d haplogroup, this haplotype has been detected in village dogs in French Polynesia and Colombia. Among breeds, it occurs in Jack Russell Terriers, Fox Terrier Wires, and Cocker Spaniels.

Some other Embark dogs with this haplotype:

The vast majority of Rottweilers have the A1d haplogroup.

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Through Otis’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.48

Map

A1a

Otis’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.48

Otis’s Haplotype

Part of the A1a haplogroup, this haplotype occurs most frequently in mixed breed dogs.

Some other Embark dogs with this haplotype:

Dogs with A1a lineage travelled during European Colonial times.

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