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“Agnes”
Open Range's Adorable Agnes

Old English Sheepdog

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“Agnes is the funniest dog. She loves to hug and give kisses. She is not a small dog so her hugs are HUGE! She will nibble at your toes if she wants your attention :)”

Current Location

Eckert, Orchard City, CO, USA

This dog has been viewed and been given 0 wags

Registration

American Kennel Club (AKC): DN54513503

Genetic Breed Result

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Old English Sheepdog

The Old English Sheepdog is a spirited breed that likes to show of its working ability and that amazing shaggy coat. These guys have been around since the early 1800's and are still best used as herding dogs. They can make great family pets as long as you are ready to fill their exercise and grooming needs.

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Genetic Stats

Predicted Adult Weight

67 lbs

Genetic Age
38 human years

Based on the date of birth provided

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Health Summary

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Agnes inherited two variants that you should learn more about.

Hereditary Ataxia, Cerebellar Degeneration

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Agnes inherited one copy of the variant we tested

What does this result mean?

This result should not impact Agnes’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Hereditary Ataxia, Cerebellar Degeneration?

Known as the "oldest" (even reptiles and more ancient species have them!) part of the brain, the cerebellum fine-tunes motor signals from the brain to the muscles, allowing for balance and coordination. When the cerebellum does not function properly, dogs become uncoordinated and do not have the ability to perform fine motor skills.

Exercise-Induced Collapse, EIC

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Agnes inherited one copy of the variant we tested

What does this result mean?

This result should not impact Agnes’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Exercise-Induced Collapse, EIC?

EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity (ABCB1)

Identified in Old English Sheepdogs

Primary Ciliary Dyskinesia, PCD (CCDC39 Exon 3, Old English Sheepdog Variant)

Identified in Old English Sheepdogs

Additional Genetic Conditions

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Clinical Tools

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Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

E Locus (MC1R)
Can have a melanistic mask (EmEm)
K Locus (CBD103)
More likely to have a mostly solid black or brown coat (KBKB)
Intensity Loci LINKAGE
No impact on coat pattern (Dilute Red Pigmentation)
A Locus (ASIP)
Not expressed (atat)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (DD)
B Locus (TYRP1)
Black or gray hair and skin (BB)
Saddle Tan (RALY)
Not expressed (NI)
S Locus (MITF)
Likely to have little to no white in coat (SS)
M Locus (PMEL)
No merle alleles (mm)
H Locus (Harlequin)
No harlequin alleles (hh)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely furnished (mustache, beard, and/or eyebrows) (FI)
Coat Length (FGF5)
Likely long coat (TT)
Shedding (MC5R)
Likely light shedding (CC)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Coat Texture (KRT71)
Likely wavy coat (CC)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (CC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Likely to have hind dew claws (CT)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Larger (NN)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Larger (TT)
Body Size (GHR - E191K)
Intermediate (GA)
Body Size (GHR - P177L)
Larger (CC)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)
Appetite (POMC) LINKAGE
Normal food motivation (NN)
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Through Agnes’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A563

Map

A1d

Open Range's Adorable Agnes’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A563

Open Range's Adorable Agnes’s Haplotype

Part of the A1d haplogroup, the A563 haplotype occurs most commonly in Old English Sheepdogs. It's a rare find!

Some other Embark dogs with this haplotype:

The vast majority of Rottweilers have the A1d haplogroup.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Agnes inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Agnes is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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