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“Nickie”
Windsong's In The Nick Of Time

Pomeranian

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Registration

American Kennel Club (AKC): TS51692601

Genetic Breed Result

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Pomeranian

The Pomeranian is a cocky, animated companion with an extroverted personality.

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Changes to this dog’s profile
  • On 2/26/2022 changed handle from "nicky76" to "nickie76"
  • On 2/26/2022 changed name from "Nicky" to "Windsong's In The Nick Of Time"

Health Summary

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Nickie inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Proportionate Dwarfism

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Nickie inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Nickie’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Nickie is unlikely to develop this condition due to this variant because she only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Proportionate Dwarfism?

Embark’s data suggests that this variant in the GH1 gene may contribute to a smaller body size. The original publication predicts this is due to a growth hormone (GH) deficiency. However, adult body size is influenced by several different genetic variants. Other changes noted by the publication, including retained baby teeth, persistent puppy-like coats, and low blood sugar have been occasionally reported by owners of dogs with two copies of this variant. These changes may or may not be associated with this variant.

ALT Activity

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Nickie inherited one copy of the variant we tested

Why is this important to your vet?

Nickie has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Nickie has this genotype, as ALT is often used as an indicator of liver health and Nickie is likely to have a lower than average resting ALT activity. As such, an increase in Nickie’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Methemoglobinemia (CYB5R3)

Identified in Pomeranians

Progressive Retinal Atrophy, rcd3 (PDE6A)

Identified in Pomeranians

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Pomeranians

Oculocutaneous Albinism, OCA (SLC45A2, Small Breed Variant)

Identified in Pomeranians

Hereditary Vitamin D-Resistant Rickets (VDR)

Identified in Pomeranians

Additional Genetic Conditions

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Through Nickie’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A288

Map

A1b

Windsong's In The Nick Of Time’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A288

Windsong's In The Nick Of Time’s Haplotype

Part of the large A1b haplogroup, this haplotype has been spotted among in village dogs in Puerto Rico. As for breeds, we see it most commonly in Poodles.

A1b is the most common haplogroup found in German Shepherds.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Nickie inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Nickie is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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