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Miss Moneypenny

Australian Shepherd

“Tiny Colorado adventure dog! Penny loves to ski, bike, hike, and trial ride. Small but mighty. A full fledge farm dog, she'll herd a cow with the best of them. Don't tell her she only weighs 16lbs!”

Instagram tag
@Two.mini.and.a.tiny.dog

Place of Birth

Evans, CO, USA

Current Location

Del Norte, Colorado, USA

From

Evans, CO, USA

This dog has been viewed and been given 21 wags

Genetic Breed Result

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Miniature/MAS-type Australian Shepherd

Miniature American Shepherds (also known as Miniature Australian Shepherds, or Mini Aussies) have the trainability, intelligence and energy of the larger Aussie cousins, and excel at outdoors activities and agility competitions.

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DNA Breed Origins

Breed colors:
Miniature/MAS-type Australian Shepherd

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Here’s what Miss Moneypenny’s family tree may have looked like.
While there may be other possible configurations of her family’s relationships, this is the most likely family tree to explain Miss Moneypenny’s breed mix.
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Health Summary

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Miss Moneypenny is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Multiple Drug Sensitivity

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Miss Moneypenny inherited one copy of the variant we tested

How to interpret this result

Miss Moneypenny has one copy of a variant at the ABCB1 gene and is at risk for displaying adverse drug reactions. While she may not be as severely affected as a dog with two copies of the ABCB1 drug sensitivity allele, normal dosages of drugs could still have potentially severe effects on Miss Moneypenny. Please inform your veterinarian that Miss Moneypenny carries this variant; it is essential that they know this information before prescribing drugs.

What is Multiple Drug Sensitivity?

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with a mutation in the ABCB1 gene.

ALT Activity

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Miss Moneypenny inherited both copies of the variant we tested

Why is this important to your vet?

Miss Moneypenny has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Miss Moneypenny's ALT activity above their current, healthy, ALT activity. As an increase above Miss Moneypenny’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, prcd

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Collie Eye Anomaly

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Canine Multifocal Retinopathy, cmr1

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Hereditary Cataracts

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Urate Kidney & Bladder Stones

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Neuronal Ceroid Lipofuscinosis 6, NCL 6

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Neuronal Ceroid Lipofuscinosis 8, NCL 8

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Craniomandibular Osteopathy, CMO

Identified in Australian Shepherds and Miniature/MAS-type Australian Shepherds

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Miss Moneypenny’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A604

Map

A1d

Miss Moneypenny’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A604

Miss Moneypenny’s Haplotype

Part of the A1d haplogroup, the A604 haplotype occurs most commonly in Australian Shepherds. It's a rare find!

The vast majority of Rottweilers have the A1d haplogroup.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Miss Moneypenny inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Miss Moneypenny is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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