Mira inherited one copy of the variant we tested
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Place of Birth
Chandler, Arizona, USA
From
Phoenix, Arizona, USA
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Health Summary
Mira inherited one variant that you should learn more about.
Exercise-Induced Collapse, EIC
What does this result mean?
This variant should not impact Mira’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Mira is unlikely to develop this condition due to this variant because she only has one copy of the variant.
Impact on Breeding
Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.
What is Exercise-Induced Collapse, EIC?
EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.
Breed-Relevant Genetic Conditions
Multiple Drug Sensitivity (ABCB1)
Identified in Old English Sheepdogs
Variant not detected
Von Willebrand Disease Type I, Type I vWD (VWF)
Identified in Standard Poodles
Variant not detected
Progressive Retinal Atrophy, prcd (PRCD Exon 1)
Identified in Golden Retrievers and Standard Poodles
Variant not detected
Golden Retriever Progressive Retinal Atrophy 1, GR-PRA1 (SLC4A3)
Identified in Golden Retrievers
Variant not detected
Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2 (TTC8)
Identified in Golden Retrievers
Variant not detected
Primary Ciliary Dyskinesia, PCD (CCDC39 Exon 3, Old English Sheepdog Variant)
Identified in Old English Sheepdogs
Variant not detected
Neuronal Ceroid Lipofuscinosis 5, NCL 5 (CLN5 Exon 4 Deletion, Golden Retriever Variant)
Identified in Golden Retrievers
Variant not detected
GM2 Gangliosidosis (HEXB, Poodle Variant)
Identified in Standard Poodles
Variant not detected
Hereditary Ataxia, Cerebellar Degeneration (RAB24, Old English Sheepdog and Gordon Setter Variant)
Identified in Old English Sheepdogs
Variant not detected
Degenerative Myelopathy, DM (SOD1A)
Identified in Golden Retrievers and Standard Poodles
Variant not detected
Neonatal Encephalopathy with Seizures, NEWS (ATF2)
Identified in Standard Poodles
Variant not detected
Leonberger Polyneuropathy 1 (LPN1, ARHGEF10)
Identified in Saint Bernards
Variant not detected
Muscular Dystrophy (DMD, Golden Retriever Variant)
Identified in Golden Retrievers
Variant not detected
Congenital Myasthenic Syndrome, CMS (COLQ, Golden Retriever Variant)
Identified in Golden Retrievers
Variant not detected
Dystrophic Epidermolysis Bullosa (COL7A1, Golden Retriever Variant)
Identified in Golden Retrievers
Variant not detected
Ichthyosis, ICH1 (PNPLA1, Golden Retriever Variant)
Identified in Golden Retrievers
Variant not detected
Osteogenesis Imperfecta (COL1A1, Golden Retriever Variant)
Identified in Golden Retrievers
Variant not detected
Osteochondrodysplasia (SLC13A1, Poodle Variant)
Identified in Standard Poodles
Variant not detected
Intervertebral Disc Disease (Type I) (FGF4 retrogene - CFA12)
Identified in Standard Poodles
Variant not detected
Retina Dysplasia and/or Optic Nerve Hypoplasia (SIX6 Exon 1, Golden Retriever Variant)
Identified in Golden Retrievers
Variant not detected
Additional Genetic Conditions
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What is a linkage test?
DNA sequences that are close together on a chromosome tend to be inherited together. Because of this, we can use genetic variation surrounding a specific variant (i.e. "linked" to it) to infer the presence or absence of a variant that is associated with a health condition or trait.
Linkage tests are not as predictive of your dog’s true genotype as direct assays, which we use on most other genetic conditions we test for.
Traits
Explore the genetics behind your dog’s appearance and size.
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Coat Color
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Coat Traits
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Body Features
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Body Size
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.