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Millie AKA The Masked Millie TKN TKI TKA TKP CGC BCAT DJ DS

Australian Cattle Dog

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“Millie has a full mask that goes completely across her face which isn't too common with dogs her breed. She also has a kinked tail at the tip. Millie's behavior is very different from typical ACDs as well. She is very friendly & outgoing, but still very much brave & protective. Millie also knows over 60+ tricks & we participate in flyball, Disc & occasionally fast CAT & barn hunt. Millie's PB for FastCAT is 26.63MPH. I provide lots of physical & mental stimulation, her breed thrives on that.”

Instagram tag
@themaskedmillie

Place of Birth

Millersburg, OH, USA

Current Location

Alliance, Ohio, USA

From

Millersburg, OH, USA

This dog has been viewed and been given 218 wags

Registration

American Kennel Club (AKC): PAL281055

Genetic Breed Result

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Australian Cattle Dog

A classic cattle dog, Australian Cattle Dogs were developed from a mixture of breeds in Australia in the 19th century, and still maintain their energetic herding instincts today.

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Changes to this dog’s profile
  • On 12/2/2020 changed name from "Millie AKA The Maked Millie" to "Millie AKA The Masked Millie"
  • On 12/2/2020 changed name from "Millie" to "Millie AKA The Maked Millie"

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Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain Millie AKA The Masked Millie’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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Millie AKA The Masked Millie is at increased risk for one genetic health condition.

And inherited three variants that you should learn more about.

Primary Lens Luxation

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Millie AKA The Masked Millie inherited one copy of the variant we tested

How to interpret this result

Millie AKA The Masked Millie has one copy of a variant in the ADAMTS17 gene and is at some risk for developing PLL. This variant is known to have an additive effect, so while dogs with one copy of the variant like Millie AKA The Masked Millie have a higher risk than dogs with two healthy alleles at ADAMTS17, their risk is much lower than a dog with two copies of the variant. Actual risk associated with having one copy of this variant appears to vary in a breed-specific manner. A study published by Gould et al 2011 supports that Tibetan Terriers with one copy of the variant have minimal risk of developing PLL, whereas this risk can range from 2-20% in other terrier breeds. Please consult with your veterinarian to discuss the best ways to monitor Millie AKA The Masked Millie's eyes and vision.

What is Primary Lens Luxation?

PLL occurs when the lens spontaneously detaches from its normal residence within the pupil, leading to reduced visual acuity. Anterior lens luxation is when the lens falls forward and posterior lens luxation is when the lens falls backwards in the eye.

Progressive Retinal Atrophy, prcd

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Millie AKA The Masked Millie inherited one copy of the variant we tested

What does this result mean?

This result does not impact your dog’s health. It could have consequences for siblings or other family members, and you should let them know if you are in contact with them.

What is Progressive Retinal Atrophy, prcd?

PRA-prcd is a retinal disease that causes progressive, non-painful vision loss. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of rod cells, leading to night blindness before day blindness.

Degenerative Myelopathy, DM

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Millie AKA The Masked Millie inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Millie AKA The Masked Millie is unlikely to develop this condition due to the variant.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Millie AKA The Masked Millie inherited both copies of the variant we tested

Why is this important to your vet?

Millie AKA The Masked Millie has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Millie AKA The Masked Millie's ALT activity above their current, healthy, ALT activity. As an increase above Millie AKA The Masked Millie’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity

Identified in Australian Cattle Dogs

Collie Eye Anomaly

Identified in Australian Cattle Dogs

Cystinuria Type II-A

Identified in Australian Cattle Dogs

Neuronal Ceroid Lipofuscinosis 5, NCL 5

Identified in Australian Cattle Dogs

Neuronal Ceroid Lipofuscinosis 8, NCL 8

Identified in Australian Cattle Dogs

Late-Onset Neuronal Ceroid Lipofuscinosis, NCL 12

Identified in Australian Cattle Dogs

Myotonia Congenita

Identified in Australian Cattle Dogs

Additional Genetic Conditions

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Through Millie AKA The Masked Millie’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1e

Haplotype

A428

Map

A1e

Millie AKA The Masked Millie’s Haplogroup

This female lineage likely stems from some of the original Central Asian wolves that were domesticated into modern dogs starting about 15,000 years ago. It seemed to be a fairly rare dog line for most of dog history until the past 300 years, when the lineage seemed to “explode” out and spread quickly. What really separates this group from the pack is its presence in Alaskan village dogs and Samoyeds. It is possible that this was an indigenous lineage brought to the Americas from Siberia when people were first starting to make that trip themselves! We see this lineage pop up in overwhelming numbers of Irish Wolfhounds, and it also occurs frequently in popular large breeds like Bernese Mountain Dogs, Saint Bernards and Great Danes. Shetland Sheepdogs are also common members of this maternal line, and we see it a lot in Boxers, too. Though it may be all mixed up with European dogs thanks to recent breeding events, its origins in the Americas makes it a very exciting lineage for sure!

A428

Millie AKA The Masked Millie’s Haplotype

Part of the A1e haplogroup, the A428 haplotype occurs most commonly in American Village Dogs. It's a rare find!

Some other Embark dogs with this haplotype:

Irish Wolfhounds are a consistent carrier of A1e.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Millie AKA The Masked Millie inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Millie AKA The Masked Millie is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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