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“Mega”
Megaladon

Rottweiler

“Custom selected for family protection and imported from Canada. His show/working pedigree reflects his fantastic disposition and intelligence. He possesses strong working character, while being a sweet and affectionate dog to his people. He’s traveled near and far and started his career being geared for APA, weight pull, rally, etc.”

Place of Birth

Canada

This dog has been viewed and been given 2 wags

Registration

Canadian Kennel Club (CKC):

Genetic Breed Result

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Rottweiler

Originally used for driving cattle and protecting valuable convoys, Rottweilers are now popular family pets as well as guard, police and military dogs.

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Here’s what Mega’s family tree may have looked like.
While there may be other possible configurations of his family’s relationships, this is the most likely family tree to explain Mega’s breed mix.
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Health Summary

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Mega inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Neuroaxonal Dystrophy, NAD

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Mega inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Mega’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Mega is unlikely to develop this condition due to this variant because he only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Neuroaxonal Dystrophy, NAD?

This group of diseases center around the neuronal axon, a specialized cellular structure that helps our nervous systems relay information across great distances. Remember: messages from the brain sometimes have to travel the entire length of your dog! Axons are the portion of the nervous system that transmit these messages quickly and reliably.

ALT Activity

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Mega inherited both copies of the variant we tested

Why is this important to your vet?

Mega has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Mega's ALT activity above their current, healthy, ALT activity. As an increase above Mega’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Juvenile Laryngeal Paralysis and Polyneuropathy (RAB3GAP1, Rottweiler Variant)

Identified in Rottweilers

Hereditary Footpad Hyperkeratosis (DSG1, Rottweiler Variant)

Identified in Rottweilers

Early Bilateral Deafness (LOXHD1 Exon 38, Rottweiler Variant)

Identified in Rottweilers

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Mega’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A11a/419

Map

A1d

Megaladon’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A11a/419

Megaladon’s Haplotype

Part of the A1d haplogroup, this haplotype occurs most frequently in Yorkshire Terriers, Old English Sheepdogs, and Miniature Schnauzers.

The vast majority of Rottweilers have the A1d haplogroup.

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Through Mega’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2b

Haplotype

Hc.10

Map

A2b

Megaladon’s Haplogroup

A2b appears to have split a few times in succession, which means that some of the Central Asian male ancestors of this lineage went their separate ways before their respective Y chromosomes made their rounds. There is not much diversity in this lineage, meaning that it has only begun to take off recently. Two iconic breeds, the Dachshund and Bloodhound, represent this lineage well. Over half of Rottweilers are A2b, as are the majority of Labrador Retrievers and Cavalier King Charles Spaniels. While A2a is restricted mostly to East Asia, this paternal line is also found among European breeds.

Hc.10

Megaladon’s Haplotype

Part of the A2b haplogroup, this haplotype occurs most commonly in Labrador Retrievers, Rottweilers, Curly-Coated Retrievers, Dandie Dinmont Terriers, and village dogs throughout the world.

A2b is found in the Daschund breed.

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