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MEGA II

American Pit Bull Terrier

“Born in Japan but his Pit bull parents are from the USA.”

Instagram tag
@myson_mega

Place of Birth

Tsukuba, Ibaraki, Japan

Current Location

Tokyo, Tokyo, Japan

From

Tsukuba, Ibaraki, Japan

This dog has been viewed and been given 791 wags

Genetic Breed Result

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American Pit Bull Terrier

The American Pit Bull Terrier originated in the British Isles and descends from the Mastiff-type dogs introduced to England in antiquity. The breed was brought over to the United States by English immigrants in the 1800s, and quickly became one of the most popular and widespread breeds there.

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Changes to this dog’s profile
  • On 8/25/2020 changed handle from "megaii" to "mega02"

Health Summary

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MEGA II inherited two variants that you should learn more about.

Urate Kidney & Bladder Stones

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MEGA II inherited one copy of the variant we tested

What does this result mean?

This variant should not impact MEGA II’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. MEGA II is unlikely to develop this condition due to this variant because he only has one copy of the variant.

Impact on Breeding

This result is also important if you decide to breed this dog - to produce the healthiest puppies we recommend genetic testing any potential mates for this condition.

What is Urate Kidney & Bladder Stones?

This condition causes kidney and bladder stones composed of urate. In most dogs, uric acid is converted to allantoin, an inert substance that is then excreted in the urine. Dogs with HUU have defects in the pathway that converts uric acid to allantoin. As such, uric acid builds up, crystallizes and forms urate stones in the kidney and bladder. Uric acid is an intermediate of purine metabolism. While hyperuricemia in other species (including humans) can lead to painful conditions such as gout, dogs do not develop systemic signs of hyperuricemia.

Progressive Retinal Atrophy, crd4/cord1

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MEGA II inherited one copy of the variant we tested

What does this result mean?

This variant should not impact MEGA II’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. MEGA II is unlikely to develop this condition due to this variant because he only has one copy of the variant.

What is Progressive Retinal Atrophy, crd4/cord1?

PRA-CRD4/cord1 is a retinal disease that causes progressive, non-painful vision loss over a 1-2 year period. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of cone cells, causing day blindness before night blindness.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, crd1

Identified in American Pit Bull Terriers

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A

Identified in American Pit Bull Terriers

L-2-Hydroxyglutaricaciduria, L2HGA

Identified in American Pit Bull Terriers

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

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Through MEGA II’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

C2

Haplotype

C42/54/55

Map

C2

MEGA II’s Haplogroup

C2 is a very old female lineage found more commonly among English Setters, English Bulldogs, and American Eskimo Dogs. We also see C2 in village dogs in South Asia. Rather than having a few characteristic breeds representing this lineage particularly well, it is present in a few uncommon individuals of many different breeds. Unlike some European breed lineages that have seen skyrocketing popularity along the path to the modern dogs we see today, C2 tends to reflect the deep history of man's best friend.

C42/54/55

MEGA II’s Haplotype

Part of the C2 haplogroup, this haplotype occurs most frequently in mixed breed dogs.

You can often find his haplogroup in the lovable English Bulldog.

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Through MEGA II’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

D

Haplotype

H10.1/Hd.4

Map

D

MEGA II’s Haplogroup

The D paternal lineage is very common in well-known populations of dogs. Breeds belonging to the D lineage likely have direct male ancestors that can be traced all the way back to the origin of domestic dogs themselves! One popular breed that commonly sports a D lineage is the Boxer. Boxers were developed in the late 19th century from Mastiff dogs, so it is no surprise that D is well represented among Mastiffs, Bulldogs, as well as Terriers. Intriguingly, D is also found among Lhasa Apsos, an ancient Tibetan breed, and Afghan Hounds. While the presence of this lineage in Polynesia or the New World can be chalked up to interbreeding with European dogs brought during voyages of discovery or later settlement, D is also well represented among village dog populations in the Middle East and Africa. If the fact that we find dogs bearing a D lineage in the Middle East (not to mention the large amount of diversity among Middle Eastern D lineage males) is any indication of ancient residence in that region, then the presence among Oceanian village dogs is peculiar. Rather, it may be that D is part of a broader Eurasian group of ancient paternal lineages which disappeared from the eastern portion of its original range, persisting in the island of New Guinea as well as West Asia and Africa. With the rise of Mastiff breeds, the D lineage received a new life as it became common among many types of working dogs.

H10.1/Hd.4

MEGA II’s Haplotype

Part of the D haplogroup, this haplotype occurs most frequently in mixed breed dogs.

The D paternal lineage is common in Boxers.

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