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Compare your dogs to Mayo Select one to begin:

Mayo

Mixed Ancestry

“He is so cute”

Place of Birth

Montana, USA

Current Location

Irvine, California, USA

From

Montana, USA

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Genetic Breed Result

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Coton de Tulear

The Coton de Tulear is a smaller breed with a cotton-like coat and lovable personality. They come from Madagascar, where they have been everything from pets of the royal family to free-ranging street dogs. They’re known as the “Royal Dog of Madagascar” and have been honored as such on a postage stamp.

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Maltese

Maltese dogs are confident and friendly toy dogs, that can be high maintenance but boast a beautiful white silky coat.

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Dogs Like Mayo

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Discover dogs who share a similar breed mix to Mayo. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
Coton de Tulear
Maltese

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Here’s what Mayo’s family tree may have looked like.
While there may be other possible configurations of his family’s relationships, this is the most likely family tree to explain Mayo’s breed mix.
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Health Summary

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Mayo is at increased risk for one genetic health condition.

And inherited two variants that you should learn more about.

Intervertebral Disc Disease (Type I)

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Mayo inherited both copies of the variant we tested

How to interpret this result

Mayo has two copies of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Degenerative Myelopathy, DM

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Mayo inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Mayo’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Mayo is unlikely to develop this condition due to this variant because he only has one copy of the variant.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Mayo inherited one copy of the variant we tested

Why is this important to your vet?

Mayo has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Mayo has this genotype, as ALT is often used as an indicator of liver health and Mayo is likely to have a lower than average resting ALT activity. As such, an increase in Mayo’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD

Identified in Coton de Tulears

Progressive Retinal Atrophy, prcd

Identified in Coton de Tulears

Canine Multifocal Retinopathy, cmr2

Identified in Coton de Tulears

Urate Kidney & Bladder Stones

Identified in Coton de Tulears

Primary Hyperoxaluria

Identified in Coton de Tulears

Glycogen Storage Disease Type IA, Von Gierke Disease, GSD IA

Identified in Malteses

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

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Through Mayo’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B147

Map

B1

Mayo’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B147

Mayo’s Haplotype

Part of the B1 haplogroup, the B147 haplotype occurs most commonly in Havaneses. It's a rare find!

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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Through Mayo’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2b

Haplotype

Hc.9

Map

A2b

Mayo’s Haplogroup

A2b appears to have split a few times in succession, which means that some of the Central Asian male ancestors of this lineage went their separate ways before their respective Y chromosomes made their rounds. There is not much diversity in this lineage, meaning that it has only begun to take off recently. Two iconic breeds, the Dachshund and Bloodhound, represent this lineage well. Over half of Rottweilers are A2b, as are the majority of Labrador Retrievers and Cavalier King Charles Spaniels. While A2a is restricted mostly to East Asia, this paternal line is also found among European breeds.

Hc.9

Mayo’s Haplotype

Part of the A2b haplogroup, this haplotype is found in village dogs spanning South America, Africa, and the South Pacific. Among the breeds we have spotted it in, the most frequent occurrences are in Dachshund, Bloodhound, American Eskimo Dog, and Jack Russell Terrier.

A2b is found in the Daschund breed.

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