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Marci

Mixed Breed

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“Rescued from the Carson Animal Shelter on August 20th, 2018. Her family became homeless and could no longer care for her. She is the best dog ever!”

Place of Birth

USA

Current Location

Gardena, California, USA

From

Carson Animal Shelter, West Victoria Street, Gardena, CA, USA

This dog has been viewed and been given 3 wags

Genetic Breed Result

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German Shepherd Dog

German Shepherds are confident, courageous dogs with a keen sense of smell and notable intelligence. These are active working dogs who excel at many canine sports and tasks -- they are true utility dogs! Their versatility combined with their loyal companionship has them consistently listed as one of the most popular breeds in the United States.

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Rottweiler

Originally used for driving cattle and protecting valuable convoys, Rottweilers are now popular family pets as well as guard, police and military dogs.

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Australian Shepherd

Australian Shepherds are an energetic mid-sized breed that make the perfect companion.

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Doberman Pinscher

Doberman Pinschers are a strong and athletic breed that are built to guard and protect.

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American Pit Bull Terrier

The American Pit Bull Terrier originated in the British Isles and descends from the Mastiff-type dogs introduced to England in antiquity. The breed was brought over to the United States by English immigrants in the 1800s, and quickly became one of the most popular and widespread breeds there.

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Dogs Like Marci

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Discover dogs who share a similar breed mix to Marci. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
German Shepherd Dog
Rottweiler
Australian Shepherd
Doberman Pinscher
American Pit Bull Terrier

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Marci
Family Tree From Embark PARENTS GRANDPARENTS GREAT GRANDPARENTS German Shepherd Dog mix Mixed German Shepherd Dog German Shepherd Dog / American Pit Bull Terrier mix Rottweiler mix Australian Shepherd / Doberman Pinscher mix German Shepherd Dog German Shepherd Dog German Shepherd Dog American Pit Bull Terrier Rottweiler Rottweiler mix Australian Shepherd Doberman Pinscher

Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain Marci’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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Marci is at increased risk for two genetic health conditions.

Multiple Drug Sensitivity

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Marci inherited one copy of the variant we tested

How to interpret this result

Marci has one copy of a variant at the ABCB1 gene and is at risk for displaying adverse drug reactions. While she may not be as severely affected as a dog with two copies of the ABCB1 drug sensitivity allele, normal dosages of drugs could still have potentially severe effects on Marci. Please inform your veterinarian that Marci carries this variant; it is essential that they know this information before prescribing drugs.

What is Multiple Drug Sensitivity?

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with a mutation in the ABCB1 gene.

Dilated Cardiomyopathy, DCM2

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Marci inherited one copy of the variant we tested

How to interpret this result

Marci has one copy of a variant in the TTN gene associated with increased risk for DCM in the American Doberman Pinscher. This variant, also referred to as DCM2, is inherited in a dominant manner, meaning having one or two copies of this variant is thought to confer the same amount of risk. However, the variant is thought to have incomplete penetrance: That is, not all dogs with this variant will ultimately show signs of DCM. Moreover, the impact of this variant in other breeds of dog besides the Doberman has yet to be fully understood. However, if your veterinarian thinks Marci shows signs of having DCM based on their diagnostic testing, you now have the opportunity to discuss early treatment. Please consult with your veterinarian regarding a diagnostic and treatment plan for Marci.

What is Dilated Cardiomyopathy, DCM2?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

Breed-Relevant Genetic Conditions

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Hemophilia A

Identified in German Shepherd Dogs

Hemophilia A

Identified in German Shepherd Dogs

Von Willebrand Disease Type I, Type I vWD

Identified in Doberman Pinschers

Canine Leukocyte Adhesion Deficiency Type III, CLAD III

Identified in German Shepherd Dogs

Progressive Retinal Atrophy, prcd

Identified in Australian Shepherds

Progressive Retinal Atrophy, crd1

Identified in American Pit Bull Terriers

Progressive Retinal Atrophy, crd2

Identified in American Pit Bull Terriers

Collie Eye Anomaly

Identified in Australian Shepherds

Day Blindness

Identified in German Shepherd Dogs

Canine Multifocal Retinopathy, cmr1

Identified in Australian Shepherds

Hereditary Cataracts

Identified in Australian Shepherds

Urate Kidney & Bladder Stones

Identified in American Pit Bull Terriers, Australian Shepherds, and more

Anhidrotic Ectodermal Dysplasia

Identified in German Shepherd Dogs

Renal Cystadenocarcinoma and Nodular Dermatofibrosis

Identified in German Shepherd Dogs

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII

Identified in German Shepherd Dogs

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A

Identified in American Pit Bull Terriers

Neuronal Ceroid Lipofuscinosis 6, NCL 6

Identified in Australian Shepherds

Neuronal Ceroid Lipofuscinosis 8, NCL 8

Identified in Australian Shepherds

Deafness and Vestibular Syndrome of Dobermans, DVDob, DINGS

Identified in Doberman Pinschers

Degenerative Myelopathy, DM

Identified in German Shepherd Dogs

L-2-Hydroxyglutaricaciduria, L2HGA

Identified in American Pit Bull Terriers

Juvenile Laryngeal Paralysis and Polyneuropathy

Identified in Rottweilers

Dilated Cardiomyopathy, DCM1

Identified in Doberman Pinschers

Craniomandibular Osteopathy, CMO

Identified in Australian Shepherds

Additional Genetic Conditions

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Clinical Tools

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Through Marci’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A253

Map

A1b

Marci’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A253

Marci’s Haplotype

Part of the large A1b haplogroup, this rare haplotype occurs in dogs with European ancestry.

Some other Embark dogs with this haplotype:

A1b is the most common haplogroup found in German Shepherds.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Marci inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Marci is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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