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“Manny”
Manny of Falnette Hystory

French Spaniel

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Place of Birth

France

Current Location

Québec, Québec, Canada

From

France

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Registration

Canadian Kennel Club (CKC): 1132700

Genetic Breed Result

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French Spaniel

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Genetic Stats

Predicted Adult Weight

62 lbs

Genetic Age
52 human years

Based on the date of birth provided

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Health Summary

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Manny inherited one variant that you should learn more about.

Degenerative Myelopathy, DM

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Manny inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Manny is unlikely to develop this condition due to the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

Breed-Relevant Genetic Conditions

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Acral Mutilation Syndrome (GDNF-AS, Spaniel and Pointer Variant)

Identified in French Spaniels

Additional Genetic Conditions

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Clinical Tools

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Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

E Locus (MC1R)
Can have a melanistic mask (EmE)
K Locus (CBD103)
More likely to have a mostly solid black or brown coat (KBKB)
Intensity Loci LINKAGE
No impact on coat pattern (Intense Red Pigmentation)
A Locus (ASIP)
Not expressed (atat)
D Locus (MLPH)
Dark areas of hair and skin are not lightened (DD)
B Locus (TYRP1)
Brown hair and skin (bb)
Saddle Tan (RALY)
Not expressed (NI)
S Locus (MITF)
Likely flash, parti, piebald, or extreme white (spsp)
M Locus (PMEL)
No merle alleles (mm)
H Locus (Harlequin)
No harlequin alleles (hh)
Other Coat Traits

Other Coat Traits

Furnishings (RSPO2) LINKAGE
Likely furnished (mustache, beard, and/or eyebrows) (FI)
Coat Length (FGF5)
Likely long coat (TT)
Shedding (MC5R)
Likely light shedding (TT)
Hairlessness (FOXI3) LINKAGE
Very unlikely to be hairless (NN)
Hairlessness (SGK3)
Very unlikely to be hairless (NN)
Oculocutaneous Albinism Type 2 (SLC45A2) LINKAGE
Likely not albino (NN)
Coat Texture (KRT71)
Likely wavy coat (CC)
Other Body Features

Other Body Features

Muzzle Length (BMP3)
Likely medium or long muzzle (CC)
Tail Length (T)
Likely normal-length tail (CC)
Hind Dewclaws (LMBR1)
Unlikely to have hind dew claws (CC)
Blue Eye Color (ALX4) LINKAGE
Less likely to have blue eyes (NN)
Back Muscling & Bulk, Large Breed (ACSL4)
Likely normal muscling (CC)
Body Size

Body Size

Body Size (IGF1)
Larger (NN)
Body Size (IGFR1)
Larger (GG)
Body Size (STC2)
Larger (TT)
Body Size (GHR - E191K)
Larger (GG)
Body Size (GHR - P177L)
Larger (CC)
Performance

Performance

Altitude Adaptation (EPAS1)
Normal altitude tolerance (GG)
Appetite (POMC) LINKAGE
Normal food motivation (NN)
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Through Manny’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1e

Haplotype

A651

Map

A1e

Manny of Falnette Hystory’s Haplogroup

This female lineage likely stems from some of the original Central Asian wolves that were domesticated into modern dogs starting about 15,000 years ago. It seemed to be a fairly rare dog line for most of dog history until the past 300 years, when the lineage seemed to “explode” out and spread quickly. What really separates this group from the pack is its presence in Alaskan village dogs and Samoyeds. It is possible that this was an indigenous lineage brought to the Americas from Siberia when people were first starting to make that trip themselves! We see this lineage pop up in overwhelming numbers of Irish Wolfhounds, and it also occurs frequently in popular large breeds like Bernese Mountain Dogs, Saint Bernards and Great Danes. Shetland Sheepdogs are also common members of this maternal line, and we see it a lot in Boxers, too. Though it may be all mixed up with European dogs thanks to recent breeding events, its origins in the Americas makes it a very exciting lineage for sure!

A651

Manny of Falnette Hystory’s Haplotype

Part of the A1e haplogroup, this haplotype occurs most frequently in Pyrenean Mastiffs.

Some other Embark dogs with this haplotype:

Irish Wolfhounds are a consistent carrier of A1e.

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Through Manny’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.59

Map

A1a

Manny of Falnette Hystory’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.59

Manny of Falnette Hystory’s Haplotype

Part of the A1a haplogroup, this haplotype occurs most frequently in European village dogs.

Some other Embark dogs with this haplotype:

Dogs with A1a lineage travelled during European Colonial times.

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