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Mandy

Mixed Breed

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“Mandy was picked up near the Marion area prison by the dog pound, which is where my wife adopted her on December 14th, 2014. She was estimated to be nine months old when my wife adopted her. When she was three my wife and I were best friends and Mandy was introduced into my life as well. She is now a senior and we are married, so she lives at home with us. She is pretty lazy, but if she gets upset she will throw tantrums and scream like a toddler. She loves anything that she considers edible.”

Current Location

Mt Gilead, Ohio, USA

From

Marion County Dog Warden, Richland Road, Marion, OH, USA

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Registration

Microchip: 990000004807485

Genetic Breed Result

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Embark Supermutt analysis

What’s in that Supermutt? There may be small amounts of DNA from these distant ancestors:

Siberian Husky

Bred initially in Northern Siberia, the Siberian Husky is a medium-sized working dog who is quick and light on their feet. Their moderately compact and well furred body, erect ears and brush tail suggest their Northern heritage. Huskies are very active and energetic and are known for being long distance sled dogs.

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Golden Retriever

Developed as an ideal hunting retriever, the Golden Retriever's eagerness to please and friendliness has made them an extremely popular family pet.

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German Shepherd Dog

German Shepherds are confident, courageous dogs with a keen sense of smell and notable intelligence. These are active working dogs who excel at many canine sports and tasks -- they are true utility dogs! Their versatility combined with their loyal companionship has them consistently listed as one of the most popular breeds in the United States.

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Rottweiler

Originally used for driving cattle and protecting valuable convoys, Rottweilers are now popular family pets as well as guard, police and military dogs.

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Dogs Like Mandy

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Discover dogs who share a similar breed mix to Mandy. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
Siberian Husky
Golden Retriever
German Shepherd Dog
Rottweiler
Supermutt

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Mandy
Family Tree From Embark PARENTS GRANDPARENTS GREAT GRANDPARENTS Mixed Siberian Husky mix Golden Retriever / Rottweiler mix German Shepherd Dog mix Siberian Husky Siberian Husky / Golden Retriever mix Golden Retriever Rottweiler mix German Shepherd Dog Mixed Siberian Husky Siberian Husky Siberian Husky Golden Retriever

Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain Mandy’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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Mandy is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Intervertebral Disc Disease (Type I)

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Mandy inherited one copy of the variant we tested

What does this result mean?

Our research indicates that this genetic variant is likely to increase the risk that Mandy will develop this disease.

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. While dogs with similar breeds to Mandy have not yet been the focus of research studies, our data indicates that Mandy is likely to be at increased risk.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

ALT Activity

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Mandy inherited one copy of the variant we tested

Why is this important to your vet?

Mandy has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Mandy has this genotype, as ALT is often used as an indicator of liver health and Mandy is likely to have a lower than average resting ALT activity. As such, an increase in Mandy’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity

Identified in German Shepherd Dogs

Hemophilia A

Identified in German Shepherd Dogs

Hemophilia A

Identified in German Shepherd Dogs

Canine Leukocyte Adhesion Deficiency Type III, CLAD III

Identified in German Shepherd Dogs

Platelet Factor X Receptor Deficiency, Scott Syndrome

Identified in German Shepherd Dogs

Progressive Retinal Atrophy, prcd

Identified in Golden Retrievers

Golden Retriever Progressive Retinal Atrophy 1, GR-PRA1

Identified in Golden Retrievers

Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2

Identified in Golden Retrievers

X-Linked Progressive Retinal Atrophy 1, XL-PRA1

Identified in Siberian Huskies

Day Blindness

Identified in Siberian Huskies

Day Blindness

Identified in German Shepherd Dogs

Urate Kidney & Bladder Stones

Identified in German Shepherd Dogs

Anhidrotic Ectodermal Dysplasia

Identified in German Shepherd Dogs

Renal Cystadenocarcinoma and Nodular Dermatofibrosis

Identified in German Shepherd Dogs

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII

Identified in German Shepherd Dogs

Neuronal Ceroid Lipofuscinosis 5, NCL 5

Identified in Golden Retrievers

GM1 Gangliosidosis

Identified in Siberian Huskies

Degenerative Myelopathy, DM

Identified in German Shepherd Dogs and Golden Retrievers

Neuroaxonal Dystrophy, NAD

Identified in Rottweilers

Juvenile Laryngeal Paralysis and Polyneuropathy

Identified in Rottweilers

Muscular Dystrophy

Identified in Golden Retrievers

Congenital Myasthenic Syndrome, CMS

Identified in Golden Retrievers

Dystrophic Epidermolysis Bullosa

Identified in Golden Retrievers

Ichthyosis, ICH1

Identified in Golden Retrievers

Hereditary Footpad Hyperkeratosis

Identified in Rottweilers

Osteogenesis Imperfecta

Identified in Golden Retrievers

Early Bilateral Deafness

Identified in Rottweilers

Additional Genetic Conditions

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Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Mandy’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1d

Haplotype

A91/11

Map

A1d

Mandy’s Haplogroup

This female lineage can be traced back about 15,000 years to some of the original Central Asian wolves that were domesticated into modern dogs. The early females that represent this lineage were likely taken into Eurasia, where they spread rapidly. As a result, many modern breed and village dogs from the Americas, Africa, through Asia and down into Oceania belong to this group! This widespread lineage is not limited to a select few breeds, but the majority of Rottweilers, Afghan Hounds and Wirehaired Pointing Griffons belong to it. It is also the most common female lineage among Papillons, Samoyeds and Jack Russell Terriers. Considering its occurrence in breeds as diverse as Afghan Hounds and Samoyeds, some of this is likely ancient variation. But because of its presence in many modern European breeds, much of its diversity likely can be attributed to much more recent breeding.

A91/11

Mandy’s Haplotype

Part of the large A1d haplogroup, this common haplotype occurs in village dogs all over the world. Among the 29 breeds that we have detected it in to date, the most frequent breeds we see expressing it are Afghan Hounds, Greater Swiss Mountain Dogs, and Borzois.

Some other Embark dogs with this haplotype:

The vast majority of Rottweilers have the A1d haplogroup.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Mandy inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Mandy is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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