Luna inherited one copy of the variant we tested
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Place of Birth
Salisbury, North Carolina, USA
Current Location
Salisbury, North Carolina, USA
From
Salisbury, North Carolina, USA
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Health Summary
Luna inherited one variant that you should learn more about.
And one variant that you should tell your vet about.
Degenerative Myelopathy, DM
What does this result mean?
This variant should not impact Luna’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Luna is unlikely to develop this condition due to this variant because she only has one copy of the variant.
Impact on Breeding
This result is also important if you decide to breed this dog - to produce the healthiest puppies we recommend genetic testing any potential mates for this condition.
What is Degenerative Myelopathy, DM?
The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.
ALT Activity
Luna inherited one copy of the variant we tested
Why is this important to your vet?
Luna has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Luna has this genotype, as ALT is often used as an indicator of liver health and Luna is likely to have a lower than average resting ALT activity. As such, an increase in Luna’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.
What is ALT Activity?
Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.
Breed-Relevant Genetic Conditions
Multiple Drug Sensitivity
Identified in German Shepherd Dogs
Variant not detected
Factor VII Deficiency
Identified in Alaskan Malamutes
Variant not detected
Hemophilia A
Identified in German Shepherd Dogs
Variant not detected
Hemophilia A
Identified in German Shepherd Dogs
Variant not detected
Canine Leukocyte Adhesion Deficiency Type III, CLAD III
Identified in German Shepherd Dogs
Variant not detected
Day Blindness
Identified in German Shepherd Dogs
Variant not detected
Urate Kidney & Bladder Stones
Identified in German Shepherd Dogs
Variant not detected
X-Linked Hereditary Nephropathy, XLHN
Identified in Samoyeds
Variant not detected
Anhidrotic Ectodermal Dysplasia
Identified in German Shepherd Dogs
Variant not detected
Renal Cystadenocarcinoma and Nodular Dermatofibrosis
Identified in German Shepherd Dogs
Variant not detected
Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII
Identified in German Shepherd Dogs
Variant not detected
GM1 Gangliosidosis
Identified in Siberian Huskies
Variant not detected
Alaskan Malamute Polyneuropathy, AMPN
Identified in Alaskan Malamutes
Variant not detected
Additional Genetic Conditions
Explore
What is a linkage test?
DNA sequences that are close together on a chromosome tend to be inherited together. Because of this, we can use genetic variation surrounding a specific variant (i.e. "linked" to it) to infer the presence or absence of a variant that is associated with a health condition or trait.
Linkage tests are not as predictive of your dog’s true genotype as direct assays, which we use on most other genetic conditions we test for.
Traits
Explore the genetics behind your dog’s appearance and size.
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Base Coat Color
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Coat Color Modifiers
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Coat Traits
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Body Features
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Body Size
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.