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Lila

Mixed Breed

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Place of Birth

Statesboro, Georgia, USA

Current Location

Augusta, Georgia, USA

From

Statesboro, Georgia, USA

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Genetic Breed Result

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Embark Supermutt analysis

What’s in that Supermutt? There may be small amounts of DNA from these distant ancestors:

American Pit Bull Terrier

The American Pit Bull Terrier originated in the British Isles and descends from the Mastiff-type dogs introduced to England in antiquity. The breed was brought over to the United States by English immigrants in the 1800s, and quickly became one of the most popular and widespread breeds there.

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Beagle

The Beagle is a scent hound and a great family pet. They are known for being affectionate and having loud voices.

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Miniature Schnauzer

Miniature Schnauzers are an alert and spirited breed with guard dog tendencies.

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Boxer

Developed in Germany, the Boxer is a popular family dog: patient, loyal and smart-requiring lots of exercise and proper training. For active families or owners looking for a rambunctious jogging buddy, Boxers may be the perfect breed. Boxers delight their humans with their sense of humor and affectionate nature.

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German Shepherd Dog

German Shepherds are confident, courageous dogs with a keen sense of smell and notable intelligence. These are active working dogs who excel at many canine sports and tasks -- they are true utility dogs! Their versatility combined with their loyal companionship has them consistently listed as one of the most popular breeds in the United States.

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DNA Breed Origins

Breed colors:
American Pit Bull Terrier
Beagle
Miniature Schnauzer
Boxer
German Shepherd Dog
Supermutt

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Lila
Family Tree From Embark PARENTS GRANDPARENTS GREAT GRANDPARENTS Mixed American Pit Bull Terrier / Beagle mix Miniature Schnauzer / American Pit Bull Terrier mix Boxer / German Shepherd Dog mix American Pit Bull Terrier Beagle Miniature Schnauzer American Pit Bull Terrier Boxer mix German Shepherd Dog mix American Pit Bull Terrier American Pit Bull Terrier Beagle Beagle

Breed Reveal Video

Our algorithms predict this is the most likely family tree to explain Lila’s breed mix, but this family tree may not be the only possible one.

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Health Summary

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Lila inherited two variants that you should learn more about.

And one variant that you should tell your vet about.

Progressive Retinal Atrophy, crd4/cord1

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Lila inherited one copy of the variant we tested

What does this result mean?

This result should not impact Lila’s health but it could have consequences for siblings or other related dogs if they inherited two copies of the variant. We recommend discussing this result with their owners or breeders if you are in contact.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring.

What is Progressive Retinal Atrophy, crd4/cord1?

PRA-CRD4/cord1 is a retinal disease that causes progressive, non-painful vision loss over a 1-2 year period. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of cone cells, causing day blindness before night blindness.

Exercise-Induced Collapse, EIC

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Lila inherited one copy of the variant we tested

What does this result mean?

Because this variant is inherited in an autosomal recessive manner (meaning dogs need two copies of the variant to develop the disease), Lila is unlikely to develop this condition due to the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Exercise-Induced Collapse, EIC?

EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.

ALT Activity

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Lila inherited one copy of the variant we tested

Why is this important to your vet?

Lila has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Lila has this genotype, as ALT is often used as an indicator of liver health and Lila is likely to have a lower than average resting ALT activity. As such, an increase in Lila’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Multiple Drug Sensitivity (ABCB1)

Identified in German Shepherd Dogs

Factor VII Deficiency (F7 Exon 5)

Identified in Beagles

Hemophilia A (F8 Exon 10, Boxer Variant)

Identified in Boxers

Hemophilia A (F8 Exon 11, German Shepherd Variant 1)

Identified in German Shepherd Dogs

Hemophilia A (F8 Exon 1, German Shepherd Variant 2)

Identified in German Shepherd Dogs

Canine Leukocyte Adhesion Deficiency Type III, CLAD III (FERMT3, German Shepherd Variant)

Identified in German Shepherd Dogs

Pyruvate Kinase Deficiency (PKLR Exon 7, Beagle Variant)

Identified in Beagles

Platelet Factor X Receptor Deficiency, Scott Syndrome (TMEM16F)

Identified in German Shepherd Dogs

Progressive Retinal Atrophy, crd1 (PDE6B, American Staffordshire Terrier Variant)

Identified in American Pit Bull Terriers

Day Blindness (CNGA3 Exon 7, German Shepherd Variant)

Identified in German Shepherd Dogs

Primary Open Angle Glaucoma (ADAMTS10 Exon 17, Beagle Variant)

Identified in Beagles

Congenital Stationary Night Blindness (LRIT3, Beagle Variant)

Identified in Beagles

Urate Kidney & Bladder Stones (SLC2A9)

Identified in American Pit Bull Terriers and German Shepherd Dogs

Anhidrotic Ectodermal Dysplasia (EDA Intron 8)

Identified in German Shepherd Dogs

Renal Cystadenocarcinoma and Nodular Dermatofibrosis (FLCN Exon 7)

Identified in German Shepherd Dogs

Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 3, German Shepherd Variant)

Identified in German Shepherd Dogs

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A (ARSG Exon 2, American Staffordshire Terrier Variant)

Identified in American Pit Bull Terriers

Persistent Mullerian Duct Syndrome, PMDS (AMHR2)

Identified in Miniature Schnauzers

Neonatal Cerebellar Cortical Degeneration (SPTBN2, Beagle Variant)

Identified in Beagles

Degenerative Myelopathy, DM (SOD1A)

Identified in Boxers and German Shepherd Dogs

L-2-Hydroxyglutaricaciduria, L2HGA (L2HGDH, Staffordshire Bull Terrier Variant)

Identified in American Pit Bull Terriers

Myotonia Congenita (CLCN1 Exon 7, Miniature Schnauzer Variant)

Identified in Miniature Schnauzers

Hypocatalasia, Acatalasemia (CAT)

Identified in Beagles

Cobalamin Malabsorption (CUBN Exon 8, Beagle Variant)

Identified in Beagles

Demyelinating Polyneuropathy (SBF2/MTRM13)

Identified in Miniature Schnauzers

Musladin-Lueke Syndrome, MLS (ADAMTSL2)

Identified in Beagles

Osteogenesis Imperfecta (COL1A2, Beagle Variant)

Identified in Beagles

Intervertebral Disc Disease (Type I) (FGF4 retrogene - CFA12)

Identified in Beagles

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Lila’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

C1

Haplotype

C7/10

Map

C1

Lila’s Haplogroup

Congratulations, C1 is a very exotic female lineage! It is more closely associated with maternal lineages found in wolves, foxes and jackals than with other dog lineages. So it seems dogs in this group have a common male dog ancestor who, many thousands of years ago, mated with a female wolf! This is not a common lineage in any breed, though a good number of German Shepherds and Doberman Pinchers are C1. It is also found in breeds as diverse as Peruvian Inca Orchids and Pekingese; it is rarely found amongst Labrador Retrievers, Border Collies, Siberian Huskies, or Cocker Spaniels. Despite its fascinating origins, it is widely distributed around the globe, and even shows up frequently among Peruvian village dogs. It almost certainly survived at low frequency in Europe for millennia and then was dispersed outside of Europe by colonialism, though not as successfully as some other lineages.

C7/10

Lila’s Haplotype

Part of the C1 haplogroup, this haplotype occurs most commonly in Pekingese, Boston Terriers, and Rat Terriers.

Some other Embark dogs with this haplotype:

The C1 maternal line is commonly found in Jackals.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Lila inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Lila is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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