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“Leo”
Art Kot Pinkerton

Chow Chow

“He is very vocal, wont stop complaining until I give him what he wants. He also has very slippery joints, falls a lot. He has been seen by a dog chiropractor and he had a torched pelvis. I also believe he had muscle and tendon issues. Leo passed away at age 2.5 due to a long battle of chronic lung infections that was unable to be diagnosed.”

Place of Birth

Moscow, Russia

Current Location

Round Lake, Illinois, USA

From

Moscow, Russia

This dog has been viewed and been given 7 wags

Registration

American Kennel Club (AKC): NP48447401

Genetic Breed Result

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Chow Chow

This distinctive-looking dog breed has a proud, independent spirit that some describe as catlike. Often aloof and suspicious of strangers, the Chow Chow may not be a cuddle buddy, but for the right person, they are a fiercely loyal companion.

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Changes to this dog’s profile
  • On 4/27/2020 changed name from "Leo" to "Art Kot Pinkerton"
Here’s what Leo’s family tree may have looked like.
While there may be other possible configurations of his family’s relationships, this is the most likely family tree to explain Leo’s breed mix.
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Health Summary

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Leo inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Degenerative Myelopathy, DM

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Leo inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Leo’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Leo is unlikely to develop this condition due to this variant because he only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Leo inherited both copies of the variant we tested

Why is this important to your vet?

Leo has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Leo's ALT activity above their current, healthy, ALT activity. As an increase above Leo’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Leo’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A5

Haplotype

A206

Map

A5

Art Kot Pinkerton’s Haplogroup

A5 is a rare maternal lineage. It is most numerous among the village dogs of Vietnam, though it is also present in the Chow Chow breed. Additionally, it is found in the Carolina Dog, and attests to this population’s origins among the indigenous native dog.

A206

Art Kot Pinkerton’s Haplotype

Part of the A5 haplogroup, this haplotype occurs most commonly in Chow Chows and Xoloitzcuintlis.

The Chow Chow is a carrier of the rare A5 haplogroup.

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Through Leo’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A2a

Haplotype

Hc.5

Map

A2a

Art Kot Pinkerton’s Haplogroup

A2a is a truly ancient lineage. Unlike the recent upstart A1 lineages which found their way from a few popular European males a couple hundred years ago into many dogs in many breeds, A2a shows ancient roots without major recent expansion. It is likely one of the oldest eastern Eurasian male lineages of dogs, where it has existed for thousands of years. Nowadays, it's commonly found in Tibetan Terriers and Chow Chows as well as in Southeastern Asian village dogs. The Chow Chow seems to have been depicted in sculpture over 2,000 years ago, so this is an ancient lineage indeed, and dogs with it have a long and noble pedigree! Males from this lineage have continued to be bred in similar forms and breeds for millennia.

Hc.5

Art Kot Pinkerton’s Haplotype

Part of the A2a haplogroup, this haplotype occurs most commonly in Chow Chows and village dogs from Papua New Guinea.

The large-sized Tibetan Mastiff descends from this ancient lineage.

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